TS1R2_HUMAN
ID TS1R2_HUMAN Reviewed; 839 AA.
AC Q8TE23; Q5TZ19;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Taste receptor type 1 member 2;
DE AltName: Full=G-protein coupled receptor 71;
DE AltName: Full=Sweet taste receptor T1R2;
DE Flags: Precursor;
GN Name=TAS1R2; Synonyms=GPR71, T1R2, TR2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS CYS-9; VAL-191; GLY-317 AND
RP VAL-486.
RX PubMed=11917125; DOI=10.1073/pnas.072090199;
RA Li X., Staszewski L., Xu H., Durick K., Zoller M., Adler E.;
RT "Human receptors for sweet and umami taste.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:4692-4696(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- FUNCTION: Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse
CC natural and synthetic sweeteners.
CC -!- SUBUNIT: Forms heterodimers with TAS1R3.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. TAS1R
CC subfamily. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Protein Spotlight; Note=The taste experience - Issue
CC 55 of February 2005;
CC URL="https://web.expasy.org/spotlight/back_issues/055";
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DR EMBL; AF458154; AAM12239.1; -; Genomic_DNA.
DR EMBL; AF458149; AAM12239.1; JOINED; Genomic_DNA.
DR EMBL; AF458150; AAM12239.1; JOINED; Genomic_DNA.
DR EMBL; AF458152; AAM12239.1; JOINED; Genomic_DNA.
DR EMBL; AF458153; AAM12239.1; JOINED; Genomic_DNA.
DR EMBL; AF458151; AAM12239.1; JOINED; Genomic_DNA.
DR EMBL; BX537160; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL831755; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK000151; DAA00019.1; -; Genomic_DNA.
DR CCDS; CCDS187.1; -.
DR RefSeq; NP_689418.2; NM_152232.2.
DR AlphaFoldDB; Q8TE23; -.
DR SMR; Q8TE23; -.
DR BioGRID; 123327; 40.
DR STRING; 9606.ENSP00000364520; -.
DR BindingDB; Q8TE23; -.
DR ChEMBL; CHEMBL1613741; -.
DR DrugBank; DB00168; Aspartame.
DR DrugBank; DB02772; Sucrose.
DR TCDB; 9.A.14.7.4; the g-protein-coupled receptor (gpcr) family.
DR GlyGen; Q8TE23; 8 sites.
DR iPTMnet; Q8TE23; -.
DR PhosphoSitePlus; Q8TE23; -.
DR BioMuta; TAS1R2; -.
DR DMDM; 116242831; -.
DR MassIVE; Q8TE23; -.
DR PaxDb; Q8TE23; -.
DR PeptideAtlas; Q8TE23; -.
DR PRIDE; Q8TE23; -.
DR ProteomicsDB; 74391; -.
DR Antibodypedia; 14734; 207 antibodies from 31 providers.
DR DNASU; 80834; -.
DR Ensembl; ENST00000375371.3; ENSP00000364520.3; ENSG00000179002.5.
DR GeneID; 80834; -.
DR KEGG; hsa:80834; -.
DR MANE-Select; ENST00000375371.4; ENSP00000364520.3; NM_152232.6; NP_689418.2.
DR UCSC; uc001bba.2; human.
DR CTD; 80834; -.
DR DisGeNET; 80834; -.
DR GeneCards; TAS1R2; -.
DR HGNC; HGNC:14905; TAS1R2.
DR HPA; ENSG00000179002; Not detected.
DR MIM; 606226; gene.
DR neXtProt; NX_Q8TE23; -.
DR OpenTargets; ENSG00000179002; -.
DR PharmGKB; PA37919; -.
DR VEuPathDB; HostDB:ENSG00000179002; -.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT00940000156136; -.
DR HOGENOM; CLU_005389_5_1_1; -.
DR InParanoid; Q8TE23; -.
DR OMA; TICISCI; -.
DR OrthoDB; 136715at2759; -.
DR PhylomeDB; Q8TE23; -.
DR TreeFam; TF331269; -.
DR PathwayCommons; Q8TE23; -.
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR Reactome; R-HSA-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR Reactome; R-HSA-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR BioGRID-ORCS; 80834; 6 hits in 1064 CRISPR screens.
DR GeneWiki; TAS1R2; -.
DR GenomeRNAi; 80834; -.
DR Pharos; Q8TE23; Tbio.
DR PRO; PR:Q8TE23; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8TE23; protein.
DR Bgee; ENSG00000179002; Expressed in skin of leg and 2 other tissues.
DR Genevisible; Q8TE23; HS.
DR GO; GO:0016021; C:integral component of membrane; IC:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0043235; C:receptor complex; IDA:MGI.
DR GO; GO:1903767; C:sweet taste receptor complex; IDA:BHF-UCL.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0033041; F:sweet taste receptor activity; IEA:Ensembl.
DR GO; GO:0008527; F:taste receptor activity; IPI:UniProtKB.
DR GO; GO:0001582; P:detection of chemical stimulus involved in sensory perception of sweet taste; IDA:HGNC-UCL.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IC:HGNC-UCL.
DR GO; GO:0032467; P:positive regulation of cytokinesis; IMP:UniProtKB.
DR GO; GO:0050916; P:sensory perception of sweet taste; IDA:UniProtKB.
DR Gene3D; 2.10.50.30; -; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; PTHR24061; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; SSF53822; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Sensory transduction; Signal; Taste;
KW Transducer; Transmembrane; Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..839
FT /note="Taste receptor type 1 member 2"
FT /id="PRO_0000012957"
FT TOPO_DOM 20..566
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 567..587
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 588..602
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 603..623
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 624..635
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 636..656
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 657..681
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 682..702
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 703..727
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 728..748
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 749..760
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 761..781
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 782..784
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 785..805
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 806..839
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 84
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 248
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 292
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 312
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 368
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 428
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 487
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 527
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 9
FT /note="S -> C (in dbSNP:rs9701796)"
FT /evidence="ECO:0000269|PubMed:11917125"
FT /id="VAR_027901"
FT VARIANT 191
FT /note="I -> V (in dbSNP:rs35874116)"
FT /evidence="ECO:0000269|PubMed:11917125"
FT /id="VAR_061199"
FT VARIANT 317
FT /note="R -> G (in dbSNP:rs34447754)"
FT /evidence="ECO:0000269|PubMed:11917125"
FT /id="VAR_061200"
FT VARIANT 486
FT /note="I -> V (in dbSNP:rs28374389)"
FT /evidence="ECO:0000269|PubMed:11917125"
FT /id="VAR_061201"
FT VARIANT 574
FT /note="A -> T (in dbSNP:rs6662276)"
FT /id="VAR_020787"
FT VARIANT 595
FT /note="I -> T (in dbSNP:rs41273167)"
FT /id="VAR_061202"
FT VARIANT 838
FT /note="R -> K (in dbSNP:rs9988418)"
FT /id="VAR_027902"
SQ SEQUENCE 839 AA; 95183 MW; A7F73516489A05F9 CRC64;
MGPRAKTISS LFFLLWVLAE PAENSDFYLP GDYLLGGLFS LHANMKGIVH LNFLQVPMCK
EYEVKVIGYN LMQAMRFAVE EINNDSSLLP GVLLGYEIVD VCYISNNVQP VLYFLAHEDN
LLPIQEDYSN YISRVVAVIG PDNSESVMTV ANFLSLFLLP QITYSAISDE LRDKVRFPAL
LRTTPSADHH IEAMVQLMLH FRWNWIIVLV SSDTYGRDNG QLLGERVARR DICIAFQETL
PTLQPNQNMT SEERQRLVTI VDKLQQSTAR VVVVFSPDLT LYHFFNEVLR QNFTGAVWIA
SESWAIDPVL HNLTELRHLG TFLGITIQSV PIPGFSEFRE WGPQAGPPPL SRTSQSYTCN
QECDNCLNAT LSFNTILRLS GERVVYSVYS AVYAVAHALH SLLGCDKSTC TKRVVYPWQL
LEEIWKVNFT LLDHQIFFDP QGDVALHLEI VQWQWDRSQN PFQSVASYYP LQRQLKNIQD
ISWHTINNTI PMSMCSKRCQ SGQKKKPVGI HVCCFECIDC LPGTFLNHTE DEYECQACPN
NEWSYQSETS CFKRQLVFLE WHEAPTIAVA LLAALGFLST LAILVIFWRH FQTPIVRSAG
GPMCFLMLTL LLVAYMVVPV YVGPPKVSTC LCRQALFPLC FTICISCIAV RSFQIVCAFK
MASRFPRAYS YWVRYQGPYV SMAFITVLKM VIVVIGMLAT GLSPTTRTDP DDPKITIVSC
NPNYRNSLLF NTSLDLLLSV VGFSFAYMGK ELPTNYNEAK FITLSMTFYF TSSVSLCTFM
SAYSGVLVTI VDLLVTVLNL LAISLGYFGP KCYMILFYPE RNTPAYFNSM IQGYTMRRD
