TS1R2_PAPHA
ID TS1R2_PAPHA Reviewed; 839 AA.
AC A3QP07;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 1.
DT 25-MAY-2022, entry version 39.
DE RecName: Full=Taste receptor type 1 member 2;
DE AltName: Full=Sweet taste receptor T1R2;
DE Flags: Precursor;
GN Name=TAS1R2;
OS Papio hamadryas (Hamadryas baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9557;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Li X., Wong E.W., Li W., Lim R., Mascioli K.J., Maehashi K.,
RA Bachmanov A.A., Tordoff M.G., Beauchamp G.K., Reed D.R.;
RT "Sweet receptor gene variation and aspartame blindness in both primates and
RT non-primates.";
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse
CC natural and synthetic sweeteners (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Forms heterodimers with TAS1R3. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. TAS1R
CC subfamily. {ECO:0000305}.
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DR EMBL; DQ386300; ABD37684.1; -; mRNA.
DR AlphaFoldDB; A3QP07; -.
DR SMR; A3QP07; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0050909; P:sensory perception of taste; IEA:UniProtKB-KW.
DR Gene3D; 2.10.50.30; -; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; PTHR24061; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00592; CASENSINGR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; SSF53822; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Sensory transduction; Signal; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..839
FT /note="Taste receptor type 1 member 2"
FT /id="PRO_0000285554"
FT TOPO_DOM 20..566
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 567..587
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 588..602
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 603..623
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 624..635
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 636..656
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 657..681
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 682..702
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 703..727
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 728..748
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 749..760
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 761..781
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 782..784
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 785..805
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 806..839
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 84
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 127
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 248
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 292
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 312
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 368
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 428
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 487
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 527
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 839 AA; 95040 MW; 2430E9E66232C1C3 CRC64;
MRPRATTICS LFFLLRVLAE PAKNSDFYLP GDYLLGGLFT LHANMKGIVH LDYLQVPMCK
EYETKVIGYN LMQAMRFAVE EINNDSSLLP DVLLGYEMVD VCYVSNNVQP VLYFLAQEDD
LLPIQENYSN YVSRVVAVIG PDNSDAVMTV ANFLSLFLLP QITYSAISDE LRDKVRFPAL
LRTAPSADHH IEAMVQLMLH FRWNWIIVLV SGDTYGRDNG QLLGDRLARG DICIAFQETL
PTVQPNQNMT SEERQRLVTI VDKLQQSTAR VVVVFSPDLT LYNFFNEVLR QNFTGAVWIA
SESWAIDPVL HNLTELRHMG TFLGITIQSV PIPGFSEFRV RDPQAGPPPL SRTSQRSTCN
QECDSCLNGT LSFNNVLRLS GERVVYSVYS AVYAVAHALH SLLGCDHGTC TKTEVYPWQL
LKEIWKVNFT LLDHQISFDP QGDMALHLEI VQWQWDLSQN PFQSVASYYP LQRQLKTIQD
ISWHTINNTI PVSMCSKRCQ SGQKKKPVGI HICCFECIDC LPGTFLNQTE DEYECQACPS
NEWSHQSEAS CFKRRLAFLE WHEAPTIVVA LLAALGFLST LAILVIFWRH FQTPMVRSAG
GPMCFLMLTL LLVAYMVVPV YVGPPKVSTC FCRQALFPLC FTICISCIAV RSFQIVCVFK
MASRFPRAYS YWVRYQGPYV SMAFITVLKM VTVVIGMLAT GLNPTTRIDP DDPKIMIVSC
NPNYRNSLFF NTGLDLLLSV VGFSFAYMGK ELPTNYNEAK FITLSMTFYF TSSVSLCTFM
SAYNGVLVTI MDLLVTVLNL LAISLGYFGP KCYMILFYPE RNTPAYFNSM IQGYTMRRD
