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TS1R2_PONPY
ID   TS1R2_PONPY             Reviewed;         839 AA.
AC   A3QP00;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Taste receptor type 1 member 2;
DE   AltName: Full=Sweet taste receptor T1R2;
DE   Flags: Precursor;
GN   Name=TAS1R2;
OS   Pongo pygmaeus (Bornean orangutan).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Li X., Wong E.W., Li W., Lim R., Mascioli K.J., Maehashi K.,
RA   Bachmanov A.A., Tordoff M.G., Beauchamp G.K., Reed D.R.;
RT   "Sweet receptor gene variation and aspartame blindness in both primates and
RT   non-primates.";
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse
CC       natural and synthetic sweeteners (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms heterodimers with TAS1R3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. TAS1R
CC       subfamily. {ECO:0000305}.
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DR   EMBL; DQ386297; ABD37677.1; -; Genomic_DNA.
DR   AlphaFoldDB; A3QP00; -.
DR   SMR; A3QP00; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0050909; P:sensory perception of taste; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.50.30; -; 1.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR000337; GPCR_3.
DR   InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR   InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR   InterPro; IPR017979; GPCR_3_CS.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PANTHER; PTHR24061; PTHR24061; 1.
DR   Pfam; PF00003; 7tm_3; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF07562; NCD3G; 1.
DR   PRINTS; PR00248; GPCRMGR.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE   3: Inferred from homology;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Receptor; Sensory transduction; Signal; Taste; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..839
FT                   /note="Taste receptor type 1 member 2"
FT                   /id="PRO_0000285555"
FT   TOPO_DOM        20..566
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        567..587
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        588..602
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        603..623
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        624..635
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        636..656
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        657..681
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        682..702
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        703..727
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        728..748
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        749..760
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        761..781
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        782..784
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        785..805
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        806..839
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        84
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        248
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        292
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        312
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        368
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        428
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        487
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        527
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   839 AA;  95051 MW;  DF5899AFBFE9B17D CRC64;
     MGPRATTICS LFFLLWVLAE PAENSDFYLP GDYLLGGLFS LHANMKGIVH LNFLQVPMCK
     EYEVKVIGYN LMQDMRFSVE EINNDSSLLP GVLLGYEMVD VCYVSNNVQP VLYFLAHEDN
     LLPIQEDYSD YVSRVVAVIG PDNSESVMTV ANFLSLFLLP QITYSAISDE LRDKVRFPAL
     LRTTPSADHH IEAMVQLMLH FRWNWIIVLV SSDTYGRDNG QLLGERLARR DICIAFQETL
     PTLQPNQNMT SEERQRLVTI VDKLQQSTAR VVVVFSPDLT LYDFFNEVLR QNFTGAVWIA
     SESWAIDPVL HNLTELRHTG TFLGITIQSV PIPGFSEFRE RDSQAGPPPL GKTSQRSTCN
     QECDNCLNAT LSFNTILRLS GERVVYSVYS AVYAVAHALH SLLGCDHSTC TKRVVYPWQL
     LEEIWKVNFT LLDHQIFFDP QGDMALHLEI VQWQWDRSQN PFQSVASYHP LQRQLKNIQD
     ISWHTINNTI PVSMCSKRCQ SGQKKKPVGI HVCCFECIDC LPGTFLNHTE DEYECQACPS
     NEWSYQSETS CFKRQLAFLE WHEAPTIAVA LLAALGFLST LAILVIFWRH FQTPMVRSAG
     GPMCFLMLTL LLVAYMVVPV YVGPPKVSTC LCRQALFPLC FTICISCIAV RSFQIICAFK
     MASRFPRAYS YWVRYQGPYV SMAFITVLKM VIVVIGMLAT GLNPTTRTDP DDPKIMIVSC
     NPNYRNSLLF NTSLDLLLSV VGFSFANMGK ELPTNYNEAK FITLSMTFYF TSSISLCTFM
     SAYSGVLVTI VDLLVTVLNL LAISLGYFGP KCYMILFYPE RNTPAYFNSV IQGYTMTRD
 
 
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