TS1R2_RAT
ID TS1R2_RAT Reviewed; 843 AA.
AC Q9Z0R7;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Taste receptor type 1 member 2;
DE AltName: Full=G-protein coupled receptor 71;
DE AltName: Full=Sweet taste receptor T1R2;
DE Flags: Precursor;
GN Name=Tas1r2; Synonyms=Gpr71, T1r2, Tr2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=Wistar; TISSUE=Circumvallate papilla;
RX PubMed=10052456; DOI=10.1016/s0092-8674(00)80658-3;
RA Hoon M.A., Adler E., Lindemeier J., Battey J.F., Ryba N.J.P., Zuker C.S.;
RT "Putative mammalian taste receptors: a class of taste-specific GPCRs with
RT distinct topographic selectivity.";
RL Cell 96:541-551(1999).
CC -!- FUNCTION: Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse
CC natural and synthetic sweeteners.
CC -!- SUBUNIT: Forms heterodimers with TAS1R3.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Abundantly expressed in circumvallate and foliate
CC papillae. {ECO:0000269|PubMed:10052456}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. TAS1R
CC subfamily. {ECO:0000305}.
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DR EMBL; AF127390; AAD18070.1; -; mRNA.
DR RefSeq; NP_001258195.1; NM_001271266.1.
DR AlphaFoldDB; Q9Z0R7; -.
DR SMR; Q9Z0R7; -.
DR GlyGen; Q9Z0R7; 9 sites.
DR PhosphoSitePlus; Q9Z0R7; -.
DR SwissPalm; Q9Z0R7; -.
DR PRIDE; Q9Z0R7; -.
DR Ensembl; ENSRNOT00000077863; ENSRNOP00000072481; ENSRNOG00000061876.
DR GeneID; 100270683; -.
DR KEGG; rno:100270683; -.
DR CTD; 80834; -.
DR RGD; 61894; Tas1r2.
DR GeneTree; ENSGT00940000156136; -.
DR HOGENOM; CLU_005389_5_1_1; -.
DR InParanoid; Q9Z0R7; -.
DR OMA; TICISCI; -.
DR OrthoDB; 136715at2759; -.
DR PhylomeDB; Q9Z0R7; -.
DR Reactome; R-RNO-418594; G alpha (i) signalling events.
DR Reactome; R-RNO-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR Reactome; R-RNO-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR PRO; PR:Q9Z0R7; -.
DR Proteomes; UP000002494; Chromosome 5.
DR Bgee; ENSRNOG00000061876; Expressed in liver and 19 other tissues.
DR ExpressionAtlas; Q9Z0R7; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IC:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043235; C:receptor complex; ISO:RGD.
DR GO; GO:1903767; C:sweet taste receptor complex; ISO:RGD.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0033041; F:sweet taste receptor activity; ISO:RGD.
DR GO; GO:0008527; F:taste receptor activity; IPI:UniProtKB.
DR GO; GO:0001582; P:detection of chemical stimulus involved in sensory perception of sweet taste; ISO:RGD.
DR GO; GO:0032467; P:positive regulation of cytokinesis; ISO:RGD.
DR GO; GO:0050916; P:sensory perception of sweet taste; IDA:UniProtKB.
DR Gene3D; 2.10.50.30; -; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; PTHR24061; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; SSF53822; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Sensory transduction; Signal; Taste;
KW Transducer; Transmembrane; Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..843
FT /note="Taste receptor type 1 member 2"
FT /id="PRO_0000012959"
FT TOPO_DOM 20..570
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 571..591
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 592..606
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 607..627
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 628..642
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 643..663
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 664..682
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 683..703
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 704..731
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 732..752
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 753..764
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 765..785
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 786..789
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 790..810
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 811..843
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 87
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 296
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 316
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 355
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 372
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 432
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 484
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 491
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 531
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 843 AA; 95800 MW; D23AC22D21E049B8 CRC64;
MGPQARTLCL LSLLLHVLPK PGKLVENSDF HLAGDYLLGG LFTLHANVKS ISHLSYLQVP
KCNEFTMKVL GYNLMQAMRF AVEEINNCSS LLPGVLLGYE MVDVCYLSNN IHPGLYFLAQ
DDDLLPILKD YSQYMPHVVA VIGPDNSESA ITVSNILSHF LIPQITYSAI SDKLRDKRHF
PSMLRTVPSA THHIEAMVQL MVHFQWNWIV VLVSDDDYGR ENSHLLSQRL TKTSDICIAF
QEVLPIPESS QVMRSEEQRQ LDNILDKLRR TSARVVVVFS PELSLYSFFH EVLRWNFTGF
VWIASESWAI DPVLHNLTEL RHTGTFLGVT IQRVSIPGFS QFRVRRDKPG YPVPNTTNLR
TTCNQDCDAC LNTTKSFNNI LILSGERVVY SVYSAVYAVA HALHRLLGCN RVRCTKQKVY
PWQLLREIWH VNFTLLGNRL FFDQQGDMPM LLDIIQWQWD LSQNPFQSIA SYSPTSKRLT
YINNVSWYTP NNTVPVSMCS KSCQPGQMKK SVGLHPCCFE CLDCMPGTYL NRSADEFNCL
SCPGSMWSYK NDITCFQRRP TFLEWHEVPT IVVAILAALG FFSTLAILFI FWRHFQTPMV
RSAGGPMCFL MLVPLLLAFG MVPVYVGPPT VFSCFCRQAF FTVCFSICLS CITVRSFQIV
CVFKMARRLP SAYSFWMRYH GPYVFVAFIT AIKVALVVGN MLATTINPIG RTDPDDPNIM
ILSCHPNYRN GLLFNTSMDL LLSVLGFSFA YMGKELPTNY NEAKFITLSM TFSFTSSISL
CTFMSVHDGV LVTIMDLLVT VLNFLAIGLG YFGPKCYMIL FYPERNTSAY FNSMIQGYTM
RKS
