TS1R3_CANLF
ID TS1R3_CANLF Reviewed; 845 AA.
AC Q49HH9;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=Taste receptor type 1 member 3;
DE AltName: Full=Sweet taste receptor T1R3;
DE Flags: Precursor;
GN Name=TAS1R3; Synonyms=T1R3;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16103917; DOI=10.1371/journal.pgen.0010003;
RA Li X., Li W., Wang H., Cao J., Maehashi K., Hong L., Bachmanov A.A.,
RA Reed D.R., Legrand-Defretin V., Beauchamp G.K., Brand J.G.;
RT "Pseudogenization of a sweet-receptor gene accounts for cats' indifference
RT toward sugar.";
RL PLoS Genet. 1:27-35(2005).
CC -!- FUNCTION: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami
CC taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3
CC recognizes diverse natural and synthetic sweeteners. TAS1R3 is
CC essential for the recognition and response to the disaccharide
CC trehalose (By similarity). Sequence differences within and between
CC species can significantly influence the selectivity and specificity of
CC taste responses (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Forms homodimers or heterodimers with TAS1R1 and TAS1R2.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. TAS1R
CC subfamily. {ECO:0000305}.
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DR EMBL; AY916759; AAX98692.1; -; mRNA.
DR RefSeq; NP_001026991.1; NM_001031821.1.
DR AlphaFoldDB; Q49HH9; -.
DR SMR; Q49HH9; -.
DR STRING; 9612.ENSCAFP00000028447; -.
DR PaxDb; Q49HH9; -.
DR PRIDE; Q49HH9; -.
DR GeneID; 489594; -.
DR KEGG; cfa:489594; -.
DR CTD; 83756; -.
DR eggNOG; KOG1056; Eukaryota.
DR InParanoid; Q49HH9; -.
DR OrthoDB; 342693at2759; -.
DR Proteomes; UP000002254; Unplaced.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0001582; P:detection of chemical stimulus involved in sensory perception of sweet taste; IEA:GOC.
DR GO; GO:0050916; P:sensory perception of sweet taste; IBA:GO_Central.
DR GO; GO:0050917; P:sensory perception of umami taste; IBA:GO_Central.
DR Gene3D; 2.10.50.30; -; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; PTHR24061; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00592; CASENSINGR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; SSF53822; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Signal; Transducer; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..845
FT /note="Taste receptor type 1 member 3"
FT /id="PRO_0000240182"
FT TOPO_DOM 19..568
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 569..589
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 590..601
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 602..622
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 623..637
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 638..658
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 659..680
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 681..701
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 702..727
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 728..748
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 749..760
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 761..781
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 782..789
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 790..810
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 811..845
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 128
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 262
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 845 AA; 92498 MW; 212743938002F64D CRC64;
MAGLMLLSLM ALLGLGAGAP LCLSRQLRMQ GDYVLGGLFP LGTAEDTGLS DRTQPNATVC
TRFSSLGLLW ALAMKMAVEE VNNRSTLLPG LRLGYDLFDT CSEPVVAMKP SLMFMAKAGS
CDIAAYCNYT QYQPRVLAVI GPHSSELALI TGKFFSFFLM PQVSYGASTD RLSNRETFPS
FFRTVSSDRV QAVAMVELLQ ELGWNWVAAV GSDDEYGRQG LSLFSSLANA RGICIAHEGL
VPLPHTSSLR LGTVQGLLHQ VNQSSVQVVV LFSSTRAART LFSYSIHCRL SPKVWVASEA
WLTSDLVMTL PGMAEVGTVL GFLQQGAPIP EFPSYVQTCL ALAADPAFCA SLDAEQPGLE
EHVVGPRCPQ CDHVTLEAMS AGLLHHQTFA AYAAVYGVAQ ALHNTLLCNA SGCPPREPVR
PWQLLENMYN LTFRVRGLAL QFDARGNVNM DYDLKLWVWR DLKPELRTVG AFNGRLKVWH
SQMSWHTPGN QRPVSQCSRQ CGEGQVRRVK GFHSCCYDCV DCKAGTYQRS PDDLLCTQCD
QNQWSPDRST RCFPRRLTFL AWGQPAVLVL LILLALALGL VLVALGLFIR HRDSPLVQAS
GGPRACFGLA CLGLVCLSVL LFPGQPGPAS CLAQQPLLHL PLTGCLSTLF LQAAQIFVGS
ELPSSWADQL RRCLQGPWAW LLVLLALLAE AALCAWYLVA FPPEVVTDWW VLPTQVLVHC
RMRSWISFGL LHAINAMLAF LCFLGTFLVQ SRPGRYNGAR GLTFAMLAYF ITWISFVPLF
ANVHVAYQPT VQMAAILLCA LGILATFHLP KCYLLLQQLE LNNPEFFLGD DARGQGSSGS
GGKET
