TS1R3_FELCA
ID TS1R3_FELCA Reviewed; 865 AA.
AC Q49KI5;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 25-MAY-2022, entry version 57.
DE RecName: Full=Taste receptor type 1 member 3;
DE Short=Taste receptor T1R3;
DE Flags: Precursor;
GN Name=TAS1R3; Synonyms=T1R3;
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=16103917; DOI=10.1371/journal.pgen.0010003;
RA Li X., Li W., Wang H., Cao J., Maehashi K., Hong L., Bachmanov A.A.,
RA Reed D.R., Legrand-Defretin V., Beauchamp G.K., Brand J.G.;
RT "Pseudogenization of a sweet-receptor gene accounts for cats' indifference
RT toward sugar.";
RL PLoS Genet. 1:27-35(2005).
CC -!- FUNCTION: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami
CC taste stimulus (the taste of monosodium glutamate) (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Forms homodimers or a heterodimer with TAS1R1.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in taste buds.
CC {ECO:0000269|PubMed:16103917}.
CC -!- MISCELLANEOUS: Unlike most mammals domestic cats do not prefer and are
CC unable to detect the sweetness of sugars. This is due to
CC pseudogenization of the TAS1R2 gene which prevents the formation of the
CC heterodimeric sweet taste receptor TAS1R2/TAS1R3. This molecular change
CC was very likely an important event in the evolution of the cat's
CC carnivorous behavior.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. TAS1R
CC subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY819786; AAX35814.1; -; mRNA.
DR RefSeq; NP_001108019.1; NM_001114547.1.
DR AlphaFoldDB; Q49KI5; -.
DR SMR; Q49KI5; -.
DR STRING; 9685.ENSFCAP00000007059; -.
DR GeneID; 100136905; -.
DR KEGG; fca:100136905; -.
DR CTD; 83756; -.
DR eggNOG; KOG1056; Eukaryota.
DR InParanoid; Q49KI5; -.
DR OrthoDB; 342693at2759; -.
DR Proteomes; UP000011712; Unplaced.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0001582; P:detection of chemical stimulus involved in sensory perception of sweet taste; IEA:GOC.
DR GO; GO:0050916; P:sensory perception of sweet taste; IBA:GO_Central.
DR GO; GO:0050917; P:sensory perception of umami taste; IBA:GO_Central.
DR Gene3D; 2.10.50.30; -; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; PTHR24061; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00592; CASENSINGR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; SSF53822; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Signal; Transducer; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..865
FT /note="Taste receptor type 1 member 3"
FT /id="PRO_0000240183"
FT TOPO_DOM 25..573
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 574..594
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 595..606
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 607..627
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 628..642
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 643..663
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 664..685
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 686..706
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 707..732
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 733..753
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 754..765
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 766..786
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 787..794
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 795..815
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 816..865
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 840..865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 134
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 267
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 865 AA; 94017 MW; 3B3F16D6B1DAB7E9 CRC64;
MPGLALLGLT ALLGLTALLD HGEGATSCLS QQLRMQGDYV LGGLFPLGSA EGTGLGDGLQ
PNATVCTRFS SLGLLWALAV KMAVEEINNG SALLPGLHLG YDLFDTCSEP MVAMKPSLVF
MAKAGSCSIA AYCNYTQYQP RVLAVIGPHS SELALVTGKF FSFFLVPQVS YGASTDRLSN
REIFPSFFRT VPSDQVQVAA MVELLEELGW NWVAAVGSDD EYGRQGLSLF SGLASARGIC
IAHEGLVPLP PGSLRLGALQ GLLRQVNQSS VQVVVLFSSA HAARTLFSYS IRCKLSPKVW
VASEAWLTSD LVMTLPGMPG VGTVLGFLQQ GAPMPEFPSY VRTRLALAAD PAFCASLDAE
QPGLEEHVVG PRCPQCDHVT LENLSAGLLH HQTFAAYAAV YGVAQALHNT LRCNASGCPR
REPVRPWQLL ENMYNVSFRA RGLALQFDAS GNVNVDYDLK LWVWQDPTPE LRTVGTFKGR
LELWRSQMCW HTPGKQQPVS QCSRQCKEGQ VRRVKGFHSC CYNCVDCKAG SYQRNPDDLL
CTQCDQDQWS PDRSTRCFAR KPMFLAWGEP AVLLLLALLA LALGLALAAL GLFLWHSDSP
LVQASGGPRA CFGLACLGLV CLSVLLFPGQ PGPASCLAQQ PLFHLPLTGC LSTFFLQAAE
IFVGSELPPS WAEKMRGRLR GPWAWLVVLL AMLAEAALCA WYLVAFPPEV VTDWRVLPTE
ALVHCHVHSW ISFGLVHATN AMLAFLCFLG TFLVQSRPGR YNGARGLTFA MLAYFITWIS
FVPLFANVHV AYQPAVQMGT ILLCALGILA TFHLPKCYLL LQRPELNTPE FFLEDNARAQ
GSSWGQGRGE SGQKQVTPDP VTSPQ
