TS1R3_GORGO
ID TS1R3_GORGO Reviewed; 852 AA.
AC Q717C1;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 64.
DE RecName: Full=Taste receptor type 1 member 3;
DE AltName: Full=Sweet taste receptor T1R3;
DE Flags: Precursor;
GN Name=TAS1R3; Synonyms=T1R3;
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Li X., Reed D.R., Tordoff M.G., Bachmanov A.A., Mascioli K.J., Bak G.,
RA Li W., Beauchamp G.K.;
RT "Analysis of the T1R taste receptor genes in primates.";
RL Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami
CC taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3
CC recognizes diverse natural and synthetic sweeteners. TAS1R3 is
CC essential for the recognition and response to the disaccharide
CC trehalose (By similarity). Sequence differences within and between
CC species can significantly influence the selectivity and specificity of
CC taste responses (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Forms homodimers or heterodimers with TAS1R1 and TAS1R2.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. TAS1R
CC subfamily. {ECO:0000305}.
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DR EMBL; AF545574; AAQ11897.1; -; Genomic_DNA.
DR AlphaFoldDB; Q717C1; -.
DR SMR; Q717C1; -.
DR STRING; 9593.ENSGGOP00000023446; -.
DR eggNOG; KOG1056; Eukaryota.
DR InParanoid; Q717C1; -.
DR Proteomes; UP000001519; Unplaced.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0001582; P:detection of chemical stimulus involved in sensory perception of sweet taste; IEA:GOC.
DR GO; GO:0050916; P:sensory perception of sweet taste; IBA:GO_Central.
DR GO; GO:0050917; P:sensory perception of umami taste; IBA:GO_Central.
DR Gene3D; 2.10.50.30; -; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; PTHR24061; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; SSF53822; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Signal; Transducer; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..852
FT /note="Taste receptor type 1 member 3"
FT /id="PRO_0000012960"
FT TOPO_DOM 21..570
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 571..591
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 592..603
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 604..624
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 625..639
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 640..660
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 661..682
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 683..703
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 704..729
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 730..750
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 751..762
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 763..783
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 784..791
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 792..812
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 813..852
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 833..852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 85
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 130
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 264
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 285
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 380
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 411
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 432
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 475
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 852 AA; 93362 MW; 13F271103EB39F45 CRC64;
MLGPAVLGLS LWALLQPGAG APLCLSQQLR MKGDYMLGGL FPLGEAEEAG FRSRTRPSSP
VCTRFSSNGL LWALAMKMAV EEINNKSDLL PGLRLGYDLF DTCSEPVVAM KPSLMFLAKA
GSRDIAAYCN YTQYQPRVLA VIGPHSSELA MVTGKFFSFF LMPQVSYGAS MELLSARETF
PSFFRTVPSD RVQLTAAAEL LQEFGWNWVA ALGSDDEYGR QGLSIFSALA AARGICIAHE
GLVPLPRADD SRLGKVQDVL HQVNQSSVQV VLLFASVHAA HALFNYSISS RLSPKVWVAS
EAWLTSDLVM GLPGMAQMGT VLGFLQRGAQ LHEFPQYVKT HLALAADPAF CSALGEREQG
LEEDVVGQRC PQCDCITLQN VSAGLNHHQT FSVYAAVYSV AQALHNTLQC NASGCPAQDP
VKPWQLLENM YNLTFHAGGL MLRFDSSGNV DMEYDLKLWV WQGSVPRLHD VGRFNGSLRT
ERLKIRWHTS DNQKPVSRCS RQCQEGQVRR VKGFHSCCYD CVDCEAGSYR QNPDDVTCTS
CGQDEWSPER STRCFHRRSR FLAWGEPAVL LLLLLLSLAL GLVLAALGLF VHHRDSPLVQ
ASGGPLACFG LVCLGLVCLS VLLFPGQPSP AQCLAQQPLS HLPLTGCLST LFLQAAEIFV
ESELPLSWAD RLSGCLRGPW AWLVVLLAML VEVALCTWYL VAFPPEVVTD WHMLPTEALV
HCRTRSWVSF GLAHATNATL AFLCFLGTFL VRSQPGRYNR ARGLTFAMLA YFITWVSFVP
LLANVQVVLR PAVQMGALLL CVLGILAAFH LPRCYLLIRQ PGLNTPEFFL GGGPGDAQGR
NDGDTGNQGK HE
