TS1R3_MOUSE
ID TS1R3_MOUSE Reviewed; 858 AA.
AC Q925D8; A2ADA0; Q91VA4; Q923K0; Q925A4; Q925D9;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Taste receptor type 1 member 3;
DE AltName: Full=Saccharin preference protein;
DE AltName: Full=Sweet taste receptor T1R3;
DE Flags: Precursor;
GN Name=Tas1r3; Synonyms=Sac, T1r3, Tr3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANTS ALA-55;
RP THR-60; LEU-61; GLN-371 AND THR-706.
RC STRAIN=C57BL/6N, and C57BL/6NCr; TISSUE=Brain, and Circumvallate papilla;
RX PubMed=11322794; DOI=10.1006/bbrc.2001.4760;
RA Kitagawa M., Kusakabe Y., Miura H., Ninomiya Y., Hino A.;
RT "Molecular genetic identification of a candidate receptor gene for sweet
RT taste.";
RL Biochem. Biophys. Res. Commun. 283:236-242(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANTS ALA-55;
RP THR-60; LEU-61; CYS-261; GLN-371; SER-692; THR-706 AND GLU-855.
RC STRAIN=C57BL/6J, DBA/2J, and SWR/J;
RC TISSUE=Circumvallate papilla, and Foliate papilla;
RX PubMed=11319557; DOI=10.1038/87440;
RA Montmayeur J.-P., Liberles S.D., Matsunami H., Buck L.B.;
RT "A candidate taste receptor gene near a sweet taste locus.";
RL Nat. Neurosci. 4:492-498(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS ALA-55 AND THR-60.
RC STRAIN=129/J, AKR/J, BALB/cByJ, C3H/HeJ, C57BL/6ByJ, C57L/J, CAST/EiJ,
RC CBA/J, DBA/2J, IS/CamEi, SEA/GnJ, ST/bJ, and SWR/J;
RX PubMed=11555487; DOI=10.1093/chemse/26.7.925;
RA Bachmanov A.A., Li X., Reed D.R., Ohmen J.D., Li S., Chen Z., Tordoff M.G.,
RA de Jong P.J., Wu C., West D.B., Chatterjee A., Ross D.A., Beauchamp G.K.;
RT "Positional cloning of the mouse saccharin preference (Sac) locus.";
RL Chem. Senses 26:925-933(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS ALA-55; THR-60; LEU-61; CYS-261;
RP GLN-371; SER-692; THR-706 AND GLU-855.
RC STRAIN=129/Sv, AKR/J, BALB/cJ, C3H/HeJ, C57BL/6J, C57L/J, DBA/1LacJ,
RC DBA/2J, FVB/N, ST/bJ, and SWR/J;
RX PubMed=11509186; DOI=10.1016/s0092-8674(01)00451-2;
RA Nelson G., Hoon M.A., Chandrashekar J., Zhang Y., Ryba N.J.P., Zuker C.S.;
RT "Mammalian sweet taste receptors.";
RL Cell 106:381-390(2001).
RN [5]
RP NUCLEOTIDE SEQUENCE, TISSUE SPECIFICITY, AND VARIANTS ALA-55; THR-60;
RP LEU-61; GLN-371; THR-706 AND GLU-855.
RC STRAIN=129/Sv, and C57BL/6J;
RX PubMed=11331418; DOI=10.1046/j.1471-4159.2001.00292.x;
RA Sainz E., Korley J.N., Battey J.F., Sullivan S.L.;
RT "Identification of a novel member of the T1R family of putative taste
RT receptors.";
RL J. Neurochem. 77:896-903(2001).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS ALA-55; THR-60 AND LEU-61.
RC STRAIN=129/SvEv, and C57BL/6J;
RX PubMed=11773963; DOI=10.1007/s0033501-2109-8;
RA Li X., Bachmanov A.A., Li S., Chen Z., Tordoff M.G., Beauchamp G.K.,
RA de Jong P.J., Wu C., Chen L., West D.B., Ross D.A., Ohmen J.D., Reed D.R.;
RT "Genetic, physical, and comparative map of the subtelomeric region of mouse
RT chromosome 4.";
RL Mamm. Genome 13:5-19(2002).
RN [7]
RP NUCLEOTIDE SEQUENCE, FUNCTION, AND VARIANT ASN-706.
RC STRAIN=C57BL/6J;
RX PubMed=12892531; DOI=10.1290/1543-706x(2003)039<0080:trtiae>2.0.co;2;
RA Ariyasu T., Matsumoto S., Kyono F., Hanaya T., Arai S., Ikeda M.,
RA Kurimoto M.;
RT "Taste receptor T1R3 is an essential molecule for the cellular recognition
RT of the disaccharide trehalose.";
RL In Vitro Cell. Dev. Biol. Anim. 39:80-88(2003).
RN [8]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-55; THR-60; LEU-61;
RP CYS-261; GLN-371; SER-692 AND THR-706, TISSUE SPECIFICITY, AND
RP GLYCOSYLATION AT ASN-58 (VARIANT THR-60).
RC STRAIN=129/SvEv, BALB/cJ, C3H/HeJ, C57BL/6J, DBA/2J, FVB/N, ST/bJ, and
RC SWR/J;
RX PubMed=11326277; DOI=10.1038/ng0501-58;
RA Max M., Shanker Y.G., Huang L., Rong M., Liu Z., Campagne F., Weinstein H.,
RA Damak S., Margolskee R.F.;
RT "Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet
RT responsiveness locus Sac.";
RL Nat. Genet. 28:58-63(2001).
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [10]
RP FUNCTION.
RX PubMed=11894099; DOI=10.1038/nature726;
RA Nelson G., Chandrashekar J., Hoon M.A., Feng L., Zhao G., Ryba N.J.P.,
RA Zuker C.S.;
RT "An amino-acid taste receptor.";
RL Nature 416:199-202(2002).
RN [11]
RP SWEET AND UMAMI TASTES EXCLUSIVELY MEDIATED BY TAS1R RECEPTORS.
RX PubMed=14636554; DOI=10.1016/s0092-8674(03)00844-4;
RA Zhao G.Q., Zhang Y., Hoon M.A., Chandrashekar J., Erlenbach I.,
RA Ryba N.J.P., Zuker C.S.;
RT "The receptors for mammalian sweet and umami taste.";
RL Cell 115:255-266(2003).
RN [12]
RP TAS1R3 INDEPENDENT SWEET- AND UMAMI-RESPONSIVE RECEPTORS.
RX PubMed=12869700; DOI=10.1126/science.1087155;
RA Damak S., Rong M., Yasumatsu K., Kokrashvili Z., Varadarajan V., Zou S.,
RA Jiang P., Ninomiya Y., Margolskee R.F.;
RT "Detection of sweet and umami taste in the absence of taste receptor
RT T1r3.";
RL Science 301:850-853(2003).
RN [13]
RP VARIANTS ALA-55; THR-60; LEU-61; CYS-261; GLN-371; SER-692; ASN-706;
RP THR-706 AND GLU-855.
RC STRAIN=129/J, AKR/J, C57BL/6J, CAST/EiJ, DBA/2J, and SWR/J;
RX PubMed=14749438; DOI=10.1523/jneurosci.1374-03.2004;
RA Reed D.R., Li S., Li X., Huang L., Tordoff M.G., Starling-Roney R.,
RA Taniguchi K., West D.B., Ohmen J.D., Beauchamp G.K., Bachmanov A.A.;
RT "Polymorphisms in the taste receptor gene (Tas1r3) region are associated
RT with saccharin preference in 30 mouse strains.";
RL J. Neurosci. 24:938-946(2004).
RN [14]
RP ALLELIC VARIATION RESPONSE TO SWEETENERS.
RC STRAIN=129/J, and C57BL/ByJ;
RX PubMed=14999080; DOI=10.1523/jneurosci.4439-03.2004;
RA Inoue M., Reed D.R., Li X., Tordoff M.G., Beauchamp G.K., Bachmanov A.A.;
RT "Allelic variation of the Tas1r3 taste receptor gene selectively affects
RT behavioral and neural taste responses to sweeteners in the F2 hybrids
RT between C57BL/6ByJ and 129P3/J mice.";
RL J. Neurosci. 24:2296-2303(2004).
CC -!- FUNCTION: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami
CC taste stimulus (the taste of monosodium glutamate) and also to most of
CC the 20 standard L-amino acids, but not to their D-enantiomers or other
CC compounds. TAS1R2/TAS1R3 recognizes diverse natural and synthetic
CC sweeteners. TAS1R3 is essential for the recognition and response to the
CC disaccharide trehalose. Sequence differences within and between species
CC can significantly influence the selectivity and specificity of taste
CC responses. {ECO:0000269|PubMed:11894099, ECO:0000269|PubMed:12892531}.
CC -!- SUBUNIT: Forms homodimers or heterodimers with TAS1R1 and TAS1R2.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in circumvallate, foliate and fungiform
CC taste papillae as well as in taste buds on the palate. Also expressed
CC in testis. Not expressed in brain, heart, kidney, liver or spleen. The
CC topographic distribution in various taste papillae is different from
CC those of other T1R members. {ECO:0000269|PubMed:11319557,
CC ECO:0000269|PubMed:11322794, ECO:0000269|PubMed:11326277,
CC ECO:0000269|PubMed:11331418}.
CC -!- PTM: The Thr-60 variant is predicted to introduce a novel N-linked
CC glycosylation site at Asn-58. The addition of even a short carbohydrate
CC group at Asn-58 is predicted to disrupt one of the contact surfaces
CC required for stability of a dimer. Therefore a Thr-60 variant N-
CC glycosylated at Asn-58 is predicted to be precluded from forming
CC homodimers or heterodimers. {ECO:0000269|PubMed:11326277}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. TAS1R
CC subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB049994; BAB47181.1; -; mRNA.
DR EMBL; AB055708; BAB62852.1; -; Genomic_DNA.
DR EMBL; AF337039; AAK39436.1; -; mRNA.
DR EMBL; AF311386; AAL08425.1; -; mRNA.
DR EMBL; AY032621; AAK51602.1; -; mRNA.
DR EMBL; AY026318; AAK01937.1; -; Genomic_DNA.
DR EMBL; AF368024; AAK55536.1; -; Genomic_DNA.
DR EMBL; AF368025; AAK55537.1; -; Genomic_DNA.
DR EMBL; AL670236; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS19046.1; -.
DR PIR; JC7683; JC7683.
DR RefSeq; NP_114078.1; NM_031872.2.
DR AlphaFoldDB; Q925D8; -.
DR SMR; Q925D8; -.
DR STRING; 10090.ENSMUSP00000030949; -.
DR GlyGen; Q925D8; 10 sites.
DR iPTMnet; Q925D8; -.
DR PaxDb; Q925D8; -.
DR PRIDE; Q925D8; -.
DR Antibodypedia; 26289; 331 antibodies from 30 providers.
DR DNASU; 83771; -.
DR Ensembl; ENSMUST00000030949; ENSMUSP00000030949; ENSMUSG00000029072.
DR GeneID; 83771; -.
DR KEGG; mmu:83771; -.
DR UCSC; uc008wff.1; mouse.
DR CTD; 83756; -.
DR MGI; MGI:1933547; Tas1r3.
DR VEuPathDB; HostDB:ENSMUSG00000029072; -.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT00940000160679; -.
DR HOGENOM; CLU_005389_1_0_1; -.
DR InParanoid; Q925D8; -.
DR OMA; MEYDLKL; -.
DR OrthoDB; 342693at2759; -.
DR PhylomeDB; Q925D8; -.
DR TreeFam; TF331269; -.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR Reactome; R-MMU-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR Reactome; R-MMU-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR BioGRID-ORCS; 83771; 5 hits in 73 CRISPR screens.
DR ChiTaRS; Tas1r3; mouse.
DR PRO; PR:Q925D8; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q925D8; protein.
DR Bgee; ENSMUSG00000029072; Expressed in ascending aorta and 43 other tissues.
DR Genevisible; Q925D8; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:1903767; C:sweet taste receptor complex; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0033041; F:sweet taste receptor activity; ISO:MGI.
DR GO; GO:0008527; F:taste receptor activity; ISO:MGI.
DR GO; GO:0001582; P:detection of chemical stimulus involved in sensory perception of sweet taste; ISO:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:MGI.
DR GO; GO:0050916; P:sensory perception of sweet taste; IGI:MGI.
DR GO; GO:0050917; P:sensory perception of umami taste; ISO:MGI.
DR Gene3D; 2.10.50.30; -; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; PTHR24061; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00592; CASENSINGR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; SSF53822; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 1: Evidence at protein level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Sensory transduction; Signal; Taste;
KW Transducer; Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..858
FT /note="Taste receptor type 1 member 3"
FT /id="PRO_0000012962"
FT TOPO_DOM 21..572
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 573..593
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 594..610
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 611..631
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 632..644
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 645..665
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 666..687
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 688..708
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 709..735
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 736..756
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 757..767
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 768..788
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 789..796
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 797..817
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 818..858
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 58
FT /note="N-linked (GlcNAc...) asparagine; when associated
FT with variant T-60"
FT /evidence="ECO:0000305|PubMed:11326277"
FT CARBOHYD 85
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 130
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 203
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 264
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 379
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 387
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 418
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 439
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 482
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 55
FT /note="T -> A (in strain: 129/J, 129/SvEv, AKR/J, BALB/c,
FT C3H/HeJ, DBA/2J and DBA/2J)"
FT /evidence="ECO:0000269|PubMed:11319557,
FT ECO:0000269|PubMed:11322794, ECO:0000269|PubMed:11326277,
FT ECO:0000269|PubMed:11331418, ECO:0000269|PubMed:11509186,
FT ECO:0000269|PubMed:11555487, ECO:0000269|PubMed:11773963,
FT ECO:0000269|PubMed:14749438"
FT VARIANT 60
FT /note="I -> T (in strain: 129/J, 129/SvEv, AKR/J, BALB/c,
FT C3H/HeJ, DBA/2J and DBA/2J; may influence the ability to
FT form dimers or bind sweeteners)"
FT /evidence="ECO:0000269|PubMed:11319557,
FT ECO:0000269|PubMed:11322794, ECO:0000269|PubMed:11326277,
FT ECO:0000269|PubMed:11331418, ECO:0000269|PubMed:11509186,
FT ECO:0000269|PubMed:11555487, ECO:0000269|PubMed:11773963,
FT ECO:0000269|PubMed:14749438"
FT VARIANT 61
FT /note="P -> L (in strain: 129/J, 129/SvEv, AKR/J, BALB/c,
FT C3H/HeJ, CAST/Ei, DBA/2J, FVB/N, ST/bJ and SWR/J)"
FT /evidence="ECO:0000269|PubMed:11319557,
FT ECO:0000269|PubMed:11322794, ECO:0000269|PubMed:11326277,
FT ECO:0000269|PubMed:11331418, ECO:0000269|PubMed:11509186,
FT ECO:0000269|PubMed:11773963, ECO:0000269|PubMed:14749438"
FT VARIANT 261
FT /note="R -> C (in strain: FVB/N, ST/bJ, SWR/J)"
FT /evidence="ECO:0000269|PubMed:11319557,
FT ECO:0000269|PubMed:11326277, ECO:0000269|PubMed:11509186,
FT ECO:0000269|PubMed:14749438"
FT VARIANT 371
FT /note="R -> Q (in strain: 129/J, 129/SvEv, AKR/J, BALB/c,
FT CAST/Ei, C3H/HeJ, DBA/2J, FVB/N, ST/bJ and SWR/J)"
FT /evidence="ECO:0000269|PubMed:11319557,
FT ECO:0000269|PubMed:11322794, ECO:0000269|PubMed:11326277,
FT ECO:0000269|PubMed:11331418, ECO:0000269|PubMed:11509186,
FT ECO:0000269|PubMed:14749438"
FT VARIANT 692
FT /note="L -> S (in strain: FVB/N, ST/bJ and SWR/J)"
FT /evidence="ECO:0000269|PubMed:11319557,
FT ECO:0000269|PubMed:11326277, ECO:0000269|PubMed:11509186,
FT ECO:0000269|PubMed:14749438"
FT VARIANT 706
FT /note="I -> N (in strain: SWR/J)"
FT /evidence="ECO:0000269|PubMed:12892531,
FT ECO:0000269|PubMed:14749438"
FT VARIANT 706
FT /note="I -> T (in strain: 129/J, 129/SvEv, AKR/J, BALB/c,
FT C3H/HeJ, DBA/2J, DBA/2J, FVB/N, ST/bJ and SWR/J)"
FT /evidence="ECO:0000269|PubMed:11319557,
FT ECO:0000269|PubMed:11322794, ECO:0000269|PubMed:11326277,
FT ECO:0000269|PubMed:11331418, ECO:0000269|PubMed:11509186,
FT ECO:0000269|PubMed:14749438"
FT VARIANT 855
FT /note="G -> E (in strain: 129/J, AKR/J, CAST/Ei, DBA/2J and
FT SWR/J)"
FT /evidence="ECO:0000269|PubMed:11319557,
FT ECO:0000269|PubMed:11331418, ECO:0000269|PubMed:11509186,
FT ECO:0000269|PubMed:14749438"
FT CONFLICT 184
FT /note="F -> L (in Ref. 8; AAK55537)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 858 AA; 94561 MW; 4E4168279DB478F8 CRC64;
MPALAIMGLS LAAFLELGMG ASLCLSQQFK AQGDYILGGL FPLGSTEEAT LNQRTQPNSI
PCNRFSPLGL FLAMAMKMAV EEINNGSALL PGLRLGYDLF DTCSEPVVTM KSSLMFLAKV
GSQSIAAYCN YTQYQPRVLA VIGPHSSELA LITGKFFSFF LMPQVSYSAS MDRLSDRETF
PSFFRTVPSD RVQLQAVVTL LQNFSWNWVA ALGSDDDYGR EGLSIFSSLA NARGICIAHE
GLVPQHDTSG QQLGKVLDVL RQVNQSKVQV VVLFASARAV YSLFSYSIHH GLSPKVWVAS
ESWLTSDLVM TLPNIARVGT VLGFLQRGAL LPEFSHYVET HLALAADPAF CASLNAELDL
EEHVMGQRCP RCDDIMLQNL SSGLLQNLSA GQLHHQIFAT YAAVYSVAQA LHNTLQCNVS
HCHVSEHVLP WQLLENMYNM SFHARDLTLQ FDAEGNVDME YDLKMWVWQS PTPVLHTVGT
FNGTLQLQQS KMYWPGNQVP VSQCSRQCKD GQVRRVKGFH SCCYDCVDCK AGSYRKHPDD
FTCTPCNQDQ WSPEKSTACL PRRPKFLAWG EPVVLSLLLL LCLVLGLALA ALGLSVHHWD
SPLVQASGGS QFCFGLICLG LFCLSVLLFP GRPSSASCLA QQPMAHLPLT GCLSTLFLQA
AETFVESELP LSWANWLCSY LRGLWAWLVV LLATFVEAAL CAWYLIAFPP EVVTDWSVLP
TEVLEHCHVR SWVSLGLVHI TNAMLAFLCF LGTFLVQSQP GRYNRARGLT FAMLAYFITW
VSFVPLLANV QVAYQPAVQM GAILVCALGI LVTFHLPKCY VLLWLPKLNT QEFFLGRNAK
KAADENSGGG EAAQGHNE
