位置:首页 > 蛋白库 > TS1R3_RAT
TS1R3_RAT
ID   TS1R3_RAT               Reviewed;         858 AA.
AC   Q923K1;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Taste receptor type 1 member 3;
DE   AltName: Full=Sweet taste receptor T1R3;
DE   Flags: Precursor;
GN   Name=Tas1r3; Synonyms=T1r3, Tr3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar; TISSUE=Circumvallate papilla;
RX   PubMed=11509186; DOI=10.1016/s0092-8674(01)00451-2;
RA   Nelson G., Hoon M.A., Chandrashekar J., Zhang Y., Ryba N.J.P., Zuker C.S.;
RT   "Mammalian sweet taste receptors.";
RL   Cell 106:381-390(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar; TISSUE=Circumvallate papilla;
RX   PubMed=11917125; DOI=10.1073/pnas.072090199;
RA   Li X., Staszewski L., Xu H., Durick K., Zoller M., Adler E.;
RT   "Human receptors for sweet and umami taste.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:4692-4696(2002).
CC   -!- FUNCTION: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami
CC       taste stimulus (the taste of monosodium glutamate) and also to most of
CC       the 20 standard L-amino acids, but not to their D-enantiomers or other
CC       compounds. TAS1R2/TAS1R3 recognizes diverse natural and synthetic
CC       sweeteners. TAS1R3 is essential for the recognition and response to the
CC       disaccharide trehalose. Sequence differences within and between species
CC       can significantly influence the selectivity and specificity of taste
CC       responses (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms homodimers or heterodimers with TAS1R1 and TAS1R2.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. TAS1R
CC       subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY032620; AAK51601.1; -; mRNA.
DR   EMBL; AF456324; AAM10636.1; -; mRNA.
DR   RefSeq; NP_570831.1; NM_130818.1.
DR   RefSeq; XP_008762556.1; XM_008764334.1.
DR   AlphaFoldDB; Q923K1; -.
DR   SMR; Q923K1; -.
DR   STRING; 10116.ENSRNOP00000026671; -.
DR   GlyGen; Q923K1; 9 sites.
DR   PaxDb; Q923K1; -.
DR   Ensembl; ENSRNOT00000026671; ENSRNOP00000026671; ENSRNOG00000019589.
DR   GeneID; 170634; -.
DR   KEGG; rno:170634; -.
DR   CTD; 83756; -.
DR   RGD; 620539; Tas1r3.
DR   eggNOG; KOG1056; Eukaryota.
DR   GeneTree; ENSGT00940000160679; -.
DR   HOGENOM; CLU_005389_1_0_1; -.
DR   InParanoid; Q923K1; -.
DR   OMA; MEYDLKL; -.
DR   OrthoDB; 342693at2759; -.
DR   PhylomeDB; Q923K1; -.
DR   TreeFam; TF331269; -.
DR   Reactome; R-RNO-418594; G alpha (i) signalling events.
DR   Reactome; R-RNO-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR   Reactome; R-RNO-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR   PRO; PR:Q923K1; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Bgee; ENSRNOG00000019589; Expressed in skeletal muscle tissue and 2 other tissues.
DR   Genevisible; Q923K1; RN.
DR   GO; GO:0016021; C:integral component of membrane; IC:UniProtKB.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:1903767; C:sweet taste receptor complex; ISO:RGD.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR   GO; GO:0033041; F:sweet taste receptor activity; IEA:Ensembl.
DR   GO; GO:0008527; F:taste receptor activity; IDA:RGD.
DR   GO; GO:0001582; P:detection of chemical stimulus involved in sensory perception of sweet taste; ISO:RGD.
DR   GO; GO:0050916; P:sensory perception of sweet taste; IDA:UniProtKB.
DR   GO; GO:0050917; P:sensory perception of umami taste; IDA:UniProtKB.
DR   Gene3D; 2.10.50.30; -; 1.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR000337; GPCR_3.
DR   InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR   InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR   InterPro; IPR017979; GPCR_3_CS.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PANTHER; PTHR24061; PTHR24061; 1.
DR   Pfam; PF00003; 7tm_3; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF07562; NCD3G; 1.
DR   PRINTS; PR00592; CASENSINGR.
DR   PRINTS; PR00248; GPCRMGR.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Receptor; Reference proteome; Sensory transduction; Signal; Taste;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..858
FT                   /note="Taste receptor type 1 member 3"
FT                   /id="PRO_0000012964"
FT   TOPO_DOM        21..575
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        576..596
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        597..610
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        611..631
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        632..644
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        645..665
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        666..687
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        688..708
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        709..735
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        736..756
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        757..767
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        768..788
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        789..796
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        797..817
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        818..858
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          839..858
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        842..858
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        85
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        130
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        203
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        264
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        379
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        387
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        418
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        439
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        482
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   858 AA;  94846 MW;  98890DAF75973B80 CRC64;
     MPGLAILGLS LAAFLELGMG SSLCLSQQFK AQGDYILGGL FPLGTTEEAT LNQRTQPNGI
     LCTRFSPLGL FLAMAMKMAV EEINNGSALL PGLRLGYDLF DTCSEPVVTM KPSLMFMAKV
     GSQSIAAYCN YTQYQPRVLA VIGPHSSELA LITGKFFSFF LMPQVSYSAS MDRLSDRETF
     PSFFRTVPSD RVQLQAVVTL LQNFSWNWVA ALGSDDDYGR EGLSIFSGLA NSRGICIAHE
     GLVPQHDTSG QQLGKVVDVL RQVNQSKVQV VVLFASARAV YSLFSYSILH DLSPKVWVAS
     ESWLTSDLVM TLPNIARVGT VLGFLQRGAL LPEFSHYVET RLALAADPTF CASLKAELDL
     EERVMGPRCS QCDYIMLQNL SSGLMQNLSA GQLHHQIFAT YAAVYSVAQA LHNTLQCNVS
     HCHTSEPVQP WQLLENMYNM SFRARDLTLQ FDAKGSVDME YDLKMWVWQS PTPVLHTVGT
     FNGTLQLQHS KMYWPGNQVP VSQCSRQCKD GQVRRVKGFH SCCYDCVDCK AGSYRKHPDD
     FTCTPCGKDQ WSPEKSTTCL PRRPKFLAWG EPAVLSLLLL LCLVLGLTLA ALGLFVHYWD
     SPLVQASGGS LFCFGLICLG LFCLSVLLFP GRPRSASCLA QQPMAHLPLT GCLSTLFLQA
     AEIFVESELP LSWANWLCSY LRGPWAWLVV LLATLVEAAL CAWYLMAFPP EVVTDWQVLP
     TEVLEHCRMR SWVSLGLVHI TNAVLAFLCF LGTFLVQSQP GRYNRARGLT FAMLAYFIIW
     VSFVPLLANV QVAYQPAVQM GAILFCALGI LATFHLPKCY VLLWLPELNT QEFFLGRSPK
     EASDGNSGSS EATRGHSE
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024