TSACC_MOUSE
ID TSACC_MOUSE Reviewed; 124 AA.
AC Q9DA44;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=TSSK6-activating co-chaperone protein;
GN Name=Tsacc;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=20829357; DOI=10.1074/jbc.m110.134767;
RA Jha K.N., Wong L., Zerfas P.M., De Silva R.S., Fan Y.X., Spiridonov N.A.,
RA Johnson G.R.;
RT "Identification of a novel HSP70-binding cochaperone critical to HSP90-
RT mediated activation of small serine/threonine kinase.";
RL J. Biol. Chem. 285:35180-35187(2010).
CC -!- FUNCTION: Co-chaperone that facilitates HSP-mediated activation of
CC TSSK6. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with HSP70. Associates with HSP90. Interacts with
CC TSSK6; this interaction is direct and recruits TSACC to HSP90 (By
CC similarity). {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: In testis, expressed in the inner luminal layer of
CC the seminiferous tubules. {ECO:0000269|PubMed:20829357}.
CC -!- SIMILARITY: Belongs to the TSACC family. {ECO:0000305}.
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DR EMBL; AK006195; BAB24452.1; -; mRNA.
DR EMBL; BC107298; AAI07299.1; -; mRNA.
DR CCDS; CCDS17467.1; -.
DR RefSeq; NP_084077.1; NM_029801.2.
DR RefSeq; XP_006502326.1; XM_006502263.2.
DR AlphaFoldDB; Q9DA44; -.
DR SMR; Q9DA44; -.
DR STRING; 10090.ENSMUSP00000010682; -.
DR PhosphoSitePlus; Q9DA44; -.
DR PaxDb; Q9DA44; -.
DR PRIDE; Q9DA44; -.
DR ProteomicsDB; 297658; -.
DR Antibodypedia; 34213; 63 antibodies from 12 providers.
DR Ensembl; ENSMUST00000010682; ENSMUSP00000010682; ENSMUSG00000010538.
DR Ensembl; ENSMUST00000107556; ENSMUSP00000103180; ENSMUSG00000010538.
DR GeneID; 76927; -.
DR KEGG; mmu:76927; -.
DR UCSC; uc008puj.1; mouse.
DR CTD; 128229; -.
DR MGI; MGI:1924177; Tsacc.
DR VEuPathDB; HostDB:ENSMUSG00000010538; -.
DR eggNOG; ENOG502SWRI; Eukaryota.
DR GeneTree; ENSGT00390000012524; -.
DR HOGENOM; CLU_162380_0_0_1; -.
DR InParanoid; Q9DA44; -.
DR OMA; RMYANLQ; -.
DR OrthoDB; 1511256at2759; -.
DR TreeFam; TF337043; -.
DR BioGRID-ORCS; 76927; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Tsacc; mouse.
DR PRO; PR:Q9DA44; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q9DA44; protein.
DR Bgee; ENSMUSG00000010538; Expressed in seminiferous tubule of testis and 156 other tissues.
DR Genevisible; Q9DA44; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0051087; F:chaperone binding; ISS:UniProtKB.
DR GO; GO:0030544; F:Hsp70 protein binding; ISO:MGI.
DR GO; GO:0019901; F:protein kinase binding; ISO:MGI.
DR GO; GO:0004860; F:protein kinase inhibitor activity; ISO:MGI.
DR GO; GO:0045860; P:positive regulation of protein kinase activity; ISO:MGI.
DR InterPro; IPR031679; SSTK-IP.
DR PANTHER; PTHR37368; PTHR37368; 1.
DR Pfam; PF15836; SSTK-IP; 1.
PE 2: Evidence at transcript level;
KW Chaperone; Reference proteome.
FT CHAIN 1..124
FT /note="TSSK6-activating co-chaperone protein"
FT /id="PRO_0000271075"
SQ SEQUENCE 124 AA; 13476 MW; 9D72065FA1AED57E CRC64;
MEQHTSNPTK EKAKEEDSVA CFCPAKSSPS YIDLPANFTP ANFLTIQTKL SSGAGQKPKG
CLGVLECMYA NLQLQTQLAQ RQIAILENLQ ASLSQPGSGR ESKNCSLPGL CCKLLLNHLP
QFHK
