C3H18_ARATH
ID C3H18_ARATH Reviewed; 536 AA.
AC Q9SJ41;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 136.
DE RecName: Full=Zinc finger CCCH domain-containing protein 18;
DE Short=AtC3H18;
DE EC=3.1.-.-;
GN OrderedLocusNames=At2g05160; ORFNames=F5G3.6;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-353, AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 418-536.
RC STRAIN=cv. Columbia;
RX PubMed=16244158; DOI=10.1104/pp.105.063479;
RA Xiao Y.-L., Smith S.R., Ishmael N., Redman J.C., Kumar N., Monaghan E.L.,
RA Ayele M., Haas B.J., Wu H.C., Town C.D.;
RT "Analysis of the cDNAs of hypothetical genes on Arabidopsis chromosome 2
RT reveals numerous transcript variants.";
RL Plant Physiol. 139:1323-1337(2005).
RN [4]
RP NOMENCLATURE.
RX PubMed=18221561; DOI=10.1186/1471-2164-9-44;
RA Wang D., Guo Y., Wu C., Yang G., Li Y., Zheng C.;
RT "Genome-wide analysis of CCCH zinc finger family in Arabidopsis and rice.";
RL BMC Genomics 9:44-44(2008).
RN [5]
RP FUNCTION.
RX PubMed=18582464; DOI=10.1016/j.febslet.2008.06.029;
RA Addepalli B., Hunt A.G.;
RT "Ribonuclease activity is a common property of Arabidopsis CCCH-containing
RT zinc-finger proteins.";
RL FEBS Lett. 582:2577-2582(2008).
CC -!- FUNCTION: Possesses ribonuclease activity in vitro.
CC {ECO:0000269|PubMed:18582464}.
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DR EMBL; AC007018; AAD29054.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC05899.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM61920.1; -; Genomic_DNA.
DR EMBL; AY429380; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AY429381; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; E84465; E84465.
DR RefSeq; NP_001324109.1; NM_001335272.1.
DR RefSeq; NP_178588.1; NM_126543.7.
DR AlphaFoldDB; Q9SJ41; -.
DR SMR; Q9SJ41; -.
DR BioGRID; 464; 3.
DR IntAct; Q9SJ41; 3.
DR STRING; 3702.AT2G05160.1; -.
DR iPTMnet; Q9SJ41; -.
DR PaxDb; Q9SJ41; -.
DR PRIDE; Q9SJ41; -.
DR ProteomicsDB; 239164; -.
DR EnsemblPlants; AT2G05160.1; AT2G05160.1; AT2G05160.
DR EnsemblPlants; AT2G05160.2; AT2G05160.2; AT2G05160.
DR GeneID; 815064; -.
DR Gramene; AT2G05160.1; AT2G05160.1; AT2G05160.
DR Gramene; AT2G05160.2; AT2G05160.2; AT2G05160.
DR KEGG; ath:AT2G05160; -.
DR Araport; AT2G05160; -.
DR TAIR; locus:2051239; AT2G05160.
DR eggNOG; ENOG502QS3A; Eukaryota.
DR HOGENOM; CLU_028778_2_0_1; -.
DR InParanoid; Q9SJ41; -.
DR OMA; RTHCESL; -.
DR OrthoDB; 821245at2759; -.
DR PhylomeDB; Q9SJ41; -.
DR PRO; PR:Q9SJ41; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9SJ41; baseline and differential.
DR Genevisible; Q9SJ41; AT.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR CDD; cd12458; RRM_AtC3H46_like; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR034365; AtC3H46-like_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR025605; OST-HTH/LOTUS_dom.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR036855; Znf_CCCH_sf.
DR Pfam; PF12872; OST-HTH; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR SUPFAM; SSF90229; SSF90229; 1.
DR PROSITE; PS51644; HTH_OST; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Hydrolase; Metal-binding; Nuclease; Reference proteome;
KW RNA-binding; Zinc; Zinc-finger.
FT CHAIN 1..536
FT /note="Zinc finger CCCH domain-containing protein 18"
FT /id="PRO_0000371977"
FT DOMAIN 211..294
FT /note="HTH OST-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT DOMAIN 317..392
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT ZN_FING 156..183
FT /note="C3H1-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT CONFLICT 351
FT /note="C -> W (in Ref. 3; AY429380)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 536 AA; 61349 MW; F30E7BE58573FA60 CRC64;
MNFTESMNVV HARIQQLEPE NAAKIFGYLL LMQENGNRDM IRLAFCPDSV MCSVINCVKY
ELARNSHHYH SPPSDHIPTP KFGSFTGSSP LSVSVSPPMK TGFWENSTEM DTLQNNLQFL
NFEDPLTSPE FSNGFFSQER QCLPLRTSRR SPSLPEFPVK ICHYFNKGFC KHGNNCRYFH
GQIIPERESF AQMFNPNNNL SDEEHVVSPV SLEKLEGEII ELLKLRRGAP ISIASLPMMY
YEKYGRTLQA EGYLTESQRH GKAGYSLTKL LARLKNTIRL VDRPHGQHSV ILAEDASKFV
EYTGERNEHG AILAGSRQIY LTFPAESSFT EHDVSIYFTS YGHVEDVRIP CQQKRMYGFV
TFASSETVKH ILAKGNPHFI CNARVLVKPY REKSRSSRYL DNYKPLHGMR YGSKFIERDI
EMNTLPPRVS ESSRMRKPFL SEPEQSVSKS LPTNYSYLGF SSDDFKLTSN AEQEEQAERL
SYLLDYLNTE DNVMNITTNY RDNDRRTHCE SLDSQVLNLP ESPFSSLSGK EISTVT
