ID   ACBD6_DICDI             Reviewed;         288 AA.
AC   Q54GC8;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Acyl-CoA-binding domain-containing protein 6 homolog;
GN   Name=acbd6; ORFNames=DDB_G0290237;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Binds long-chain acyl-coenzyme A molecules with a strong
CC       preference for unsaturated C18:1-CoA. Does not bind fatty acids (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; AAFI02000161; EAL62340.1; -; Genomic_DNA.
DR   RefSeq; XP_635850.1; XM_630758.1.
DR   AlphaFoldDB; Q54GC8; -.
DR   SMR; Q54GC8; -.
DR   STRING; 44689.DDB0266382; -.
DR   PaxDb; Q54GC8; -.
DR   EnsemblProtists; EAL62340; EAL62340; DDB_G0290237.
DR   GeneID; 8627558; -.
DR   KEGG; ddi:DDB_G0290237; -.
DR   dictyBase; DDB_G0290237; acbd6.
DR   eggNOG; KOG0817; Eukaryota.
DR   HOGENOM; CLU_050309_1_0_1; -.
DR   InParanoid; Q54GC8; -.
DR   OMA; MKARSKW; -.
DR   PhylomeDB; Q54GC8; -.
DR   Reactome; R-DDI-77289; Mitochondrial Fatty Acid Beta-Oxidation.
DR   PRO; PR:Q54GC8; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000062; F:fatty-acyl-CoA binding; IBA:GO_Central.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR000582; Acyl-CoA-binding_protein.
DR   InterPro; IPR035984; Acyl-CoA-binding_sf.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   Pfam; PF00887; ACBP; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   PRINTS; PR00689; ACOABINDINGP.
DR   SMART; SM00248; ANK; 2.
DR   SUPFAM; SSF47027; SSF47027; 1.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS51228; ACB_2; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   3: Inferred from homology;
KW   ANK repeat; Cytoplasm; Lipid-binding; Reference proteome; Repeat.
FT   CHAIN           1..288
FT                   /note="Acyl-CoA-binding domain-containing protein 6
FT                   homolog"
FT                   /id="PRO_0000328232"
FT   DOMAIN          6..94
FT                   /note="ACB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00573"
FT   REPEAT          200..229
FT                   /note="ANK 1"
FT   REPEAT          233..263
FT                   /note="ANK 2"
FT   BINDING         36..40
FT                   /ligand="an acyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:58342"
FT                   /evidence="ECO:0000250"
FT   BINDING         62
FT                   /ligand="an acyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:58342"
FT                   /evidence="ECO:0000250"
FT   BINDING         81
FT                   /ligand="an acyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:58342"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   288 AA;  32891 MW;  AE9647B662CAD7F5 CRC64;
     MTDAQIENKF KLAVDYITNN SGKLSNIKNE EQLYLYCNYK QATIGDCNTK APPFYDYIGK
     SKWNSWNSLK GVEKIVAMNS YISLVNALSP GWDSNIKVER ATQSVFLNDE EFKELEKKEK
     EEKEELKKLE EENGGEIEKP KSKWMGPVLS KFSLVDDETL EKLEKNTKQD LGYWVSVNDI
     ERVKKEIEND KNIINEVDED GRTALIWACD RGYFEIAKLL IENGSNVNVQ DGEGMTPLHY
     AVVCDQFEIC KLLLSQSSID KSIKDNSDSI PSDFIDSSTS ENIKSLFK