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C3H2_ARATH
ID   C3H2_ARATH              Reviewed;         393 AA.
AC   Q9ZWA1; Q8GZ44;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Zinc finger CCCH domain-containing protein 2 {ECO:0000303|PubMed:18221561};
DE            Short=AtC3H2 {ECO:0000303|PubMed:18221561};
DE   AltName: Full=Protein SOMNUS {ECO:0000303|PubMed:18487351};
DE            Short=SOM {ECO:0000303|PubMed:18487351};
DE   AltName: Full=Tandem CCCH Zinc Finger protein 4 {ECO:0000303|PubMed:26978070};
DE            Short=AtTZF4 {ECO:0000303|PubMed:26978070};
GN   Name=TZF4 {ECO:0000303|PubMed:26978070};
GN   Synonyms=SOM {ECO:0000303|PubMed:18487351};
GN   OrderedLocusNames=At1g03790 {ECO:0000312|Araport:AT1G03790};
GN   ORFNames=F11M21.28 {ECO:0000312|EMBL:AAD10689.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11910074; DOI=10.1126/science.1071006;
RA   Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA   Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA   Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA   Shinagawa A., Shinozaki K.;
RT   "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL   Science 296:141-145(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [5]
RP   NOMENCLATURE.
RX   PubMed=18221561; DOI=10.1186/1471-2164-9-44;
RA   Wang D., Guo Y., Wu C., Yang G., Li Y., Zheng C.;
RT   "Genome-wide analysis of CCCH zinc finger family in Arabidopsis and rice.";
RL   BMC Genomics 9:44-44(2008).
RN   [6]
RP   FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=18487351; DOI=10.1105/tpc.108.058859;
RA   Kim D.H., Yamaguchi S., Lim S., Oh E., Park J., Hanada A., Kamiya Y.,
RA   Choi G.;
RT   "SOMNUS, a CCCH-type zinc finger protein in Arabidopsis, negatively
RT   regulates light-dependent seed germination downstream of PIL5.";
RL   Plant Cell 20:1260-1277(2008).
RN   [7]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=cv. Columbia;
RX   PubMed=22483719; DOI=10.1016/j.devcel.2012.01.024;
RA   Cho J.-N., Ryu J.-Y., Jeong Y.-M., Park J., Song J.-J., Amasino R.M.,
RA   Noh B., Noh Y.-S.;
RT   "Control of seed germination by light-induced histone arginine
RT   demethylation activity.";
RL   Dev. Cell 22:736-748(2012).
RN   [8]
RP   INTERACTION WITH MARD1 AND RD21A.
RX   PubMed=26978070; DOI=10.1371/journal.pone.0151574;
RA   Bogamuwa S., Jang J.C.;
RT   "Plant tandem CCCH zinc finger proteins interact with ABA, drought, and
RT   stress response regulators in processing-bodies and stress granules.";
RL   PLoS ONE 11:E0151574-E0151574(2016).
CC   -!- FUNCTION: Probable transcription repressor that functions as negative
CC       regulator of phytochrome-mediated promotion of seed germination.
CC       Inhibits seed germination by regulating the expression of gibberellic
CC       acid (GA) and abscisic acid (ABA) metabolic genes. Does not regulate
CC       the expression of the DELLA genes RGA and RGA1. Activated by PIL5, a
CC       phytochrome-interacting basic helix-loop-helix transcription factor
CC       (PubMed:18487351). Represses directly JMJ20 and JMJ22 expression in the
CC       absence of red light (R) and in far-red (FR) conditions
CC       (PubMed:22483719). {ECO:0000269|PubMed:18487351,
CC       ECO:0000269|PubMed:22483719}.
CC   -!- SUBUNIT: Interacts with MARD1/FLZ9 and RD21A.
CC       {ECO:0000269|PubMed:26978070}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18487351}.
CC   -!- TISSUE SPECIFICITY: Specifically expressed in seeds.
CC       {ECO:0000269|PubMed:18487351}.
CC   -!- DISRUPTION PHENOTYPE: Increased levels of JMJ20 and JMJ22 in far-red
CC       (FR) conditions. {ECO:0000269|PubMed:22483719}.
CC   -!- MISCELLANEOUS: Plants lacking SOM germinate in darkness, independently
CC       of various light regimens.
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DR   EMBL; AC003027; AAD10689.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE27614.1; -; Genomic_DNA.
DR   EMBL; AK117219; BAC41895.1; -; mRNA.
DR   EMBL; BT005342; AAO63406.1; -; mRNA.
DR   PIR; D86168; D86168.
DR   RefSeq; NP_171875.1; NM_100258.3.
DR   AlphaFoldDB; Q9ZWA1; -.
DR   BioGRID; 24643; 7.
DR   IntAct; Q9ZWA1; 7.
DR   STRING; 3702.AT1G03790.1; -.
DR   PaxDb; Q9ZWA1; -.
DR   PRIDE; Q9ZWA1; -.
DR   ProteomicsDB; 240447; -.
DR   EnsemblPlants; AT1G03790.1; AT1G03790.1; AT1G03790.
DR   GeneID; 839408; -.
DR   Gramene; AT1G03790.1; AT1G03790.1; AT1G03790.
DR   KEGG; ath:AT1G03790; -.
DR   Araport; AT1G03790; -.
DR   TAIR; locus:2024112; AT1G03790.
DR   eggNOG; KOG1595; Eukaryota.
DR   HOGENOM; CLU_044407_3_0_1; -.
DR   InParanoid; Q9ZWA1; -.
DR   OMA; SDPDLGW; -.
DR   OrthoDB; 937629at2759; -.
DR   PhylomeDB; Q9ZWA1; -.
DR   PRO; PR:Q9ZWA1; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9ZWA1; baseline and differential.
DR   Genevisible; Q9ZWA1; AT.
DR   GO; GO:0005634; C:nucleus; IDA:TAIR.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0010187; P:negative regulation of seed germination; IMP:TAIR.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR   InterPro; IPR045234; Unkempt-like.
DR   InterPro; IPR000571; Znf_CCCH.
DR   InterPro; IPR036855; Znf_CCCH_sf.
DR   PANTHER; PTHR14493; PTHR14493; 1.
DR   Pfam; PF00642; zf-CCCH; 1.
DR   SMART; SM00356; ZnF_C3H1; 2.
DR   SUPFAM; SSF90229; SSF90229; 1.
DR   PROSITE; PS50103; ZF_C3H1; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Germination; Metal-binding; Nucleus; Reference proteome;
KW   Repeat; Repressor; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..393
FT                   /note="Zinc finger CCCH domain-containing protein 2"
FT                   /id="PRO_0000371964"
FT   ZN_FING         122..150
FT                   /note="C3H1-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   ZN_FING         159..181
FT                   /note="C3H1-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   REGION          1..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..41
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..71
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        360
FT                   /note="M -> I (in Ref. 3; BAC41895 and 4; AAO63406)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   393 AA;  43614 MW;  4DF703696ED090B4 CRC64;
     MDVVCTEHQM RKPTVEIPPR KLLLSSKSFP SDSSSPRSPR KHNWNKSNKI TSEHEEDNED
     NNRENKEYCY DSDSDDPYAS DHFRMFEFKI RRCTRSRSHD WTDCPFAHPG EKARRRDPRR
     FQYSGEVCPE FRRGGDCSRG DDCEFAHGVF ECWLHPIRYR TEACKDGKHC KRKVCFFAHS
     PRQLRVLPPE NVSGVSASPS PAAKNPCCLF CSSSPTSTLL GNLSHLSRSP SLSPPMSPAN
     KAAAFSRLRN RAASAVSAAA AAGSMNYKDV LSELVNSLDS MSLAEALQAS SSSPVTTPVS
     AAAAAFASSC GLSNQRLHLQ QQQPSSPLQF ALSPSTPSYL TNSPQANFFS DDFTPRRRQM
     NDFTAMTAVR ENTNIEDGSC GDPDLGWVND LLT
 
 
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