C3H37_ARATH
ID C3H37_ARATH Reviewed; 524 AA.
AC Q941Q3; Q0WPD0; Q9C7B5; Q9LTW6;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Zinc finger CCCH domain-containing protein 37;
DE Short=AtC3H37;
DE AltName: Full=ENHANCER OF AG-4 protein 1;
GN Name=HUA1; OrderedLocusNames=At3g12680; ORFNames=T2E22.1;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=11595801; DOI=10.2307/3871507;
RA Li J., Jia D., Chen X.;
RT "HUA1, a regulator of stamen and carpel identities in Arabidopsis, codes
RT for a nuclear RNA binding protein.";
RL Plant Cell 13:2269-2281(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-524.
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH HEN4.
RX PubMed=12530963; DOI=10.1016/s1534-5807(02)00399-4;
RA Cheng Y., Kato N., Wang W., Li J., Chen X.;
RT "Two RNA binding proteins, HEN4 and HUA1, act in the processing of AGAMOUS
RT pre-mRNA in Arabidopsis thaliana.";
RL Dev. Cell 4:53-66(2003).
RN [7]
RP NOMENCLATURE.
RX PubMed=18221561; DOI=10.1186/1471-2164-9-44;
RA Wang D., Guo Y., Wu C., Yang G., Li Y., Zheng C.;
RT "Genome-wide analysis of CCCH zinc finger family in Arabidopsis and rice.";
RL BMC Genomics 9:44-44(2008).
RN [8]
RP INTERACTION WITH FLK AND PEP.
RX PubMed=25658099; DOI=10.1371/journal.pgen.1004983;
RA Rodriguez-Cazorla E., Ripoll J.J., Andujar A., Bailey L.J.,
RA Martinez-Laborda A., Yanofsky M.F., Vera A.;
RT "K-homology nuclear ribonucleoproteins regulate floral organ identity and
RT determinacy in arabidopsis.";
RL PLoS Genet. 11:E1004983-E1004983(2015).
CC -!- FUNCTION: Involved in flower development (PubMed:11595801,
CC PubMed:12530963). Functions in floral reproductive organ identity by
CC binding AGAMOUS (AG) pre-mRNA and promoting its processing. Functions
CC in association with HUA2 and HEN4 (PubMed:12530963).
CC {ECO:0000269|PubMed:11595801, ECO:0000269|PubMed:12530963}.
CC -!- SUBUNIT: Interacts with HEN4 (PubMed:12530963). Interacts with FLK and
CC PEP (PubMed:25658099). {ECO:0000269|PubMed:12530963,
CC ECO:0000269|PubMed:25658099}.
CC -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:11595801,
CC ECO:0000269|PubMed:12530963}. Note=Nuclear with a speckled distribution
CC pattern.
CC -!- TISSUE SPECIFICITY: Highly expressed in inflorescences, at intermediate
CC levels in leaves and stems and at lower levels in roots.
CC {ECO:0000269|PubMed:11595801}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB02412.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY024357; AAK01470.1; -; mRNA.
DR EMBL; AB024033; BAB02412.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC069474; AAG51026.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE75231.1; -; Genomic_DNA.
DR EMBL; AK229145; BAF01019.1; -; mRNA.
DR RefSeq; NP_187874.2; NM_112103.3.
DR AlphaFoldDB; Q941Q3; -.
DR BioGRID; 5782; 2.
DR STRING; 3702.AT3G12680.1; -.
DR PaxDb; Q941Q3; -.
DR PRIDE; Q941Q3; -.
DR ProteomicsDB; 239114; -.
DR EnsemblPlants; AT3G12680.1; AT3G12680.1; AT3G12680.
DR GeneID; 820448; -.
DR Gramene; AT3G12680.1; AT3G12680.1; AT3G12680.
DR KEGG; ath:AT3G12680; -.
DR Araport; AT3G12680; -.
DR TAIR; locus:2087775; AT3G12680.
DR eggNOG; KOG1677; Eukaryota.
DR HOGENOM; CLU_033292_0_1_1; -.
DR InParanoid; Q941Q3; -.
DR OMA; YMMTRTC; -.
DR OrthoDB; 657700at2759; -.
DR PhylomeDB; Q941Q3; -.
DR PRO; PR:Q941Q3; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q941Q3; baseline and differential.
DR Genevisible; Q941Q3; AT.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003729; F:mRNA binding; IDA:TAIR.
DR GO; GO:0003723; F:RNA binding; IDA:TAIR.
DR GO; GO:0001709; P:cell fate determination; TAS:TAIR.
DR GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR InterPro; IPR045877; ZFP36-like.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR036855; Znf_CCCH_sf.
DR PANTHER; PTHR12547; PTHR12547; 1.
DR Pfam; PF00642; zf-CCCH; 6.
DR SMART; SM00356; ZnF_C3H1; 6.
DR SUPFAM; SSF90229; SSF90229; 6.
DR PROSITE; PS50103; ZF_C3H1; 6.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; DNA-binding; Flowering;
KW Metal-binding; mRNA processing; Nucleus; Reference proteome; Repeat;
KW RNA-binding; Zinc; Zinc-finger.
FT CHAIN 1..524
FT /note="Zinc finger CCCH domain-containing protein 37"
FT /id="PRO_0000371992"
FT ZN_FING 174..202
FT /note="C3H1-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 225..253
FT /note="C3H1-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 268..296
FT /note="C3H1-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 340..368
FT /note="C3H1-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 420..448
FT /note="C3H1-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 473..501
FT /note="C3H1-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT REGION 19..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 300..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 505..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 524 AA; 57654 MW; 843EA2C7AF624A4A CRC64;
MAHRQLYSYA LQPSYAAAAS TVSPAPPPPQ QPLPPKTGLS SLYGSSADHY FPDTTYRFLA
RDGSEALSNY SGTLASSSSM YHHLPNTTAS HLAYPQLLQH QEVAWPPGVE VPGAASAVEP
LPPGVKRTSE ALYYPTLLGA HNTIGQTEAW YTTDYFTKRP KLESTSHLPI YPQRAGEKDC
THYMQTRTCK FGESCRFDHP IWVPEGGIPD WKEAPVVPNE EYPERPGEPD CPYYIKTQRC
KYGSKCKFNH PREEAAVSVE TQDSLPERPS EPMCTFYMKT GKCKFGLSCK FHHPKDIQLP
SSSQDIGSSV GLTSEPDATN NPHVTFTPAL YHNSKGLPVR SGEVDCPFYL KTGSCKYGAT
CRYNHPERTA FIPQAAGVNY SLVSSNTANL NLGLVTPATS FYQTLTQPTL GVISATYPQR
PGQSECDYYM KTGECKFGER CKFHHPADRL SAMTKQAPQQ PNVKLSLAGY PRREGALNCP
YYMKTGTCKY GATCKFDHPP PGEVMAKTTS EADAAGATNT DTTQ
