C3H48_ARATH
ID C3H48_ARATH Reviewed; 430 AA.
AC Q9FNZ2;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Zinc finger CCCH domain-containing protein 48;
DE Short=AtC3H48;
DE AltName: Full=Zinc finger CCCH domain and WD40 repeat-containing protein 1;
GN Name=ZFWD1; OrderedLocusNames=At4g25440; ORFNames=T30C3.6;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11137290; DOI=10.1016/s0378-1119(00)00446-7;
RA Terol J., Bargues M., Perez-Alonso M.;
RT "ZFWD: a novel subfamily of plant proteins containing a C3H zinc finger and
RT seven WD40 repeats.";
RL Gene 260:45-53(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Kim C.J., Chen H., Quinitio C., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NOMENCLATURE.
RX PubMed=18221561; DOI=10.1186/1471-2164-9-44;
RA Wang D., Guo Y., Wu C., Yang G., Li Y., Zheng C.;
RT "Genome-wide analysis of CCCH zinc finger family in Arabidopsis and rice.";
RL BMC Genomics 9:44-44(2008).
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DR EMBL; AJ252063; CAC19847.1; -; mRNA.
DR EMBL; AL079350; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002687; AEE85060.1; -; Genomic_DNA.
DR EMBL; CP002687; ANM67105.1; -; Genomic_DNA.
DR EMBL; CP002687; ANM67106.1; -; Genomic_DNA.
DR EMBL; BT026122; ABG48478.1; -; mRNA.
DR RefSeq; NP_001328956.1; NM_001341743.1.
DR RefSeq; NP_001328957.1; NM_001341744.1.
DR RefSeq; NP_194274.2; NM_118676.4.
DR AlphaFoldDB; Q9FNZ2; -.
DR SMR; Q9FNZ2; -.
DR BioGRID; 13936; 3.
DR IntAct; Q9FNZ2; 3.
DR STRING; 3702.AT4G25440.1; -.
DR PaxDb; Q9FNZ2; -.
DR PRIDE; Q9FNZ2; -.
DR ProteomicsDB; 240484; -.
DR EnsemblPlants; AT4G25440.1; AT4G25440.1; AT4G25440.
DR EnsemblPlants; AT4G25440.2; AT4G25440.2; AT4G25440.
DR EnsemblPlants; AT4G25440.3; AT4G25440.3; AT4G25440.
DR GeneID; 828649; -.
DR Gramene; AT4G25440.1; AT4G25440.1; AT4G25440.
DR Gramene; AT4G25440.2; AT4G25440.2; AT4G25440.
DR Gramene; AT4G25440.3; AT4G25440.3; AT4G25440.
DR KEGG; ath:AT4G25440; -.
DR Araport; AT4G25440; -.
DR TAIR; locus:2131799; AT4G25440.
DR eggNOG; KOG0274; Eukaryota.
DR HOGENOM; CLU_037680_0_0_1; -.
DR InParanoid; Q9FNZ2; -.
DR OMA; MNGGNTR; -.
DR OrthoDB; 757685at2759; -.
DR PhylomeDB; Q9FNZ2; -.
DR PRO; PR:Q9FNZ2; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9FNZ2; baseline and differential.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR044715; WDR86-like.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR036855; Znf_CCCH_sf.
DR PANTHER; PTHR44489; PTHR44489; 1.
DR Pfam; PF00400; WD40; 2.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SMART; SM00356; ZnF_C3H1; 2.
DR SUPFAM; SSF50978; SSF50978; 1.
DR SUPFAM; SSF90229; SSF90229; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
DR PROSITE; PS50103; ZF_C3H1; 2.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Reference proteome; Repeat; WD repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..430
FT /note="Zinc finger CCCH domain-containing protein 48"
FT /id="PRO_0000372002"
FT REPEAT 142..183
FT /note="WD 1"
FT REPEAT 221..258
FT /note="WD 2"
FT REPEAT 265..304
FT /note="WD 3"
FT REPEAT 306..342
FT /note="WD 4"
FT REPEAT 345..389
FT /note="WD 5"
FT REPEAT 391..429
FT /note="WD 6"
FT ZN_FING 26..52
FT /note="C3H1-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 102..129
FT /note="C3H1-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 56..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 430 AA; 46662 MW; 52E03292B96EC150 CRC64;
MDLDMNGGNK RVFQRLGGGS NRPTTDSNQK VCFHWRAGRC NRYPCPYLHR ELPGPGSGPV
AASSNKRVAD ESGFAGPSHR RGPGFSGTAN NWGRFGGNRT VTKTEKLCKF WVDGNCPYGD
KCRYLHCWSK GDSFSLLTQL DGHQKVVTGI ALPSGSDKLY TASKDETVRI WDCASGQCTG
VLNLGGEVGC IISEGPWLLV GMPNLVKAWN IQNNADLSLN GPVGQVYSLV VGTDLLFAGT
QDGSILVWRY NSTTSCFDPA ASLLGHTLAV VSLYVGANRL YSGAMDNSIK VWSLDNLQCI
QTLTEHTSVV MSLICWDQFL LSCSLDNTVK IWAATEGGNL EVTYTHKEEY GVLALCGVHD
AEAKPVLLCS CNDNSLHLYD LPSFTERGKI LAKQEIRSIQ IGPGGIFFTG DGSGQVKVWK
WSTESTPILS
