C3H4_ARATH
ID C3H4_ARATH Reviewed; 481 AA.
AC Q9LNV5; Q93XZ5;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 132.
DE RecName: Full=Zinc finger CCCH domain-containing protein 4;
DE Short=AtC3H4;
GN OrderedLocusNames=At1g07360; ORFNames=F22G5.30;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NOMENCLATURE.
RX PubMed=18221561; DOI=10.1186/1471-2164-9-44;
RA Wang D., Guo Y., Wu C., Yang G., Li Y., Zheng C.;
RT "Genome-wide analysis of CCCH zinc finger family in Arabidopsis and rice.";
RL BMC Genomics 9:44-44(2008).
CC -!- INTERACTION:
CC Q9LNV5; Q0WPF2: PCFS4; NbExp=3; IntAct=EBI-2430550, EBI-1775648;
CC Q9LNV5; Q9S7W5: TCP13; NbExp=3; IntAct=EBI-2430550, EBI-4424877;
CC Q9LNV5; Q9C9L2: TCP15; NbExp=3; IntAct=EBI-2430550, EBI-4426144;
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DR EMBL; AC022464; AAF79557.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28114.1; -; Genomic_DNA.
DR EMBL; AY054519; AAK96710.1; -; mRNA.
DR EMBL; AY114632; AAM47951.1; -; mRNA.
DR PIR; F86208; F86208.
DR RefSeq; NP_563788.1; NM_100610.4.
DR AlphaFoldDB; Q9LNV5; -.
DR SMR; Q9LNV5; -.
DR BioGRID; 22489; 26.
DR IntAct; Q9LNV5; 23.
DR STRING; 3702.AT1G07360.1; -.
DR PaxDb; Q9LNV5; -.
DR PRIDE; Q9LNV5; -.
DR ProteomicsDB; 240574; -.
DR EnsemblPlants; AT1G07360.1; AT1G07360.1; AT1G07360.
DR GeneID; 837248; -.
DR Gramene; AT1G07360.1; AT1G07360.1; AT1G07360.
DR KEGG; ath:AT1G07360; -.
DR Araport; AT1G07360; -.
DR TAIR; locus:2025077; AT1G07360.
DR eggNOG; KOG0153; Eukaryota.
DR HOGENOM; CLU_027112_2_0_1; -.
DR InParanoid; Q9LNV5; -.
DR OMA; RTNDTIM; -.
DR OrthoDB; 1272857at2759; -.
DR PhylomeDB; Q9LNV5; -.
DR PRO; PR:Q9LNV5; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9LNV5; baseline and differential.
DR Genevisible; Q9LNV5; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR GO; GO:0071006; C:U2-type catalytic step 1 spliceosome; IBA:GO_Central.
DR GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003729; F:mRNA binding; IDA:TAIR.
DR GO; GO:0036002; F:pre-mRNA binding; IBA:GO_Central.
DR GO; GO:0017070; F:U6 snRNA binding; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IGI:TAIR.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR039171; Cwc2/Slt11.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR032297; Torus.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR036855; Znf_CCCH_sf.
DR PANTHER; PTHR14089; PTHR14089; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF16131; Torus; 1.
DR SMART; SM00360; RRM; 1.
DR SMART; SM00356; ZnF_C3H1; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR SUPFAM; SSF90229; SSF90229; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Reference proteome; RNA-binding; Zinc;
KW Zinc-finger.
FT CHAIN 1..481
FT /note="Zinc finger CCCH domain-containing protein 4"
FT /id="PRO_0000371965"
FT DOMAIN 228..301
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT ZN_FING 157..184
FT /note="C3H1-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT REGION 329..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..350
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..387
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..403
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..442
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..481
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 305
FT /note="Q -> R (in Ref. 3; AAM47951/AAK96710)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 481 AA; 53588 MW; 1EF5A5E6D5A2926D CRC64;
MAHRILRDHE ADGWERSDFP IICESCLGDN PYVRMTKANY DKECKICTRP FTVFRWRPGR
DARYKKTEIC QTCCKLKNVC QVCLLDLEYG LPVQVRDTAL NISTHDSIPK SDVNREYFAE
EHDRKARAGL DYESSFGKMR PNDTILKLQR TTPYYKRNRA HVCSFFIRGE CTRGAECPYR
HEMPETGELS QQNIKDRYYG VNDPVAMKLL GKAGEMGTLE SPDDESIKTL YVGGLNSRIL
EQDIRDQFYA HGEIESIRIL ADKACAFVTY TSREGAEKAA QELSNRLVIN GQRLKLTWGR
PKPDQDGANQ QGGVAHSGLL PRAVISQQHN QPPPMQQYYM HPPPANQDKP YYPSMDPQRM
GAVISTQEAG GSSTENNGAS SSSYMMPPHQ SYPPPPYGYM PSPYQQQYPP NHHHQPSPMQ
HYAPPPAAYP YPQQPGPGSR PAPSPTAVSA ISPDSAPAGS GAPSGSSQQA PDVSTATGSS
Q
