ACBD7_HUMAN
ID ACBD7_HUMAN Reviewed; 88 AA.
AC Q8N6N7; A6NCI2; B3KTG8;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Acyl-CoA-binding domain-containing protein 7;
GN Name=ACBD7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
RG Structural genomics consortium (SGC);
RT "Crystal structure of human acyl-COA binding domain 7 complexed with
RT palmitoyl-COA.";
RL Submitted (JAN-2009) to the PDB data bank.
CC -!- FUNCTION: Binds medium- and long-chain acyl-CoA esters.
CC -!- INTERACTION:
CC Q8N6N7; Q14696: MESD; NbExp=3; IntAct=EBI-18657673, EBI-6165891;
CC Q8N6N7; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-18657673, EBI-11139477;
CC -!- SIMILARITY: Belongs to the ACBD7 family. {ECO:0000305}.
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DR EMBL; AK095538; BAG53080.1; -; mRNA.
DR EMBL; AL590365; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471072; EAW86243.1; -; Genomic_DNA.
DR EMBL; BC029526; AAH29526.1; -; mRNA.
DR CCDS; CCDS31153.1; -.
DR RefSeq; NP_001034933.1; NM_001039844.2.
DR PDB; 3EPY; X-ray; 2.00 A; A/B=1-88.
DR PDBsum; 3EPY; -.
DR AlphaFoldDB; Q8N6N7; -.
DR SMR; Q8N6N7; -.
DR BioGRID; 135940; 14.
DR IntAct; Q8N6N7; 13.
DR STRING; 9606.ENSP00000367453; -.
DR GlyGen; Q8N6N7; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q8N6N7; -.
DR PhosphoSitePlus; Q8N6N7; -.
DR BioMuta; ACBD7; -.
DR DMDM; 74751066; -.
DR EPD; Q8N6N7; -.
DR jPOST; Q8N6N7; -.
DR MassIVE; Q8N6N7; -.
DR MaxQB; Q8N6N7; -.
DR PaxDb; Q8N6N7; -.
DR PeptideAtlas; Q8N6N7; -.
DR PRIDE; Q8N6N7; -.
DR ProteomicsDB; 72208; -.
DR Antibodypedia; 44133; 152 antibodies from 19 providers.
DR DNASU; 414149; -.
DR Ensembl; ENST00000356189.6; ENSP00000367453.4; ENSG00000176244.7.
DR GeneID; 414149; -.
DR KEGG; hsa:414149; -.
DR MANE-Select; ENST00000356189.6; ENSP00000367453.4; NM_001039844.3; NP_001034933.1.
DR UCSC; uc001inv.4; human.
DR CTD; 414149; -.
DR GeneCards; ACBD7; -.
DR HGNC; HGNC:17715; ACBD7.
DR HPA; ENSG00000176244; Tissue enhanced (brain, choroid plexus).
DR neXtProt; NX_Q8N6N7; -.
DR OpenTargets; ENSG00000176244; -.
DR PharmGKB; PA134884059; -.
DR VEuPathDB; HostDB:ENSG00000176244; -.
DR eggNOG; KOG0817; Eukaryota.
DR GeneTree; ENSGT00940000161184; -.
DR HOGENOM; CLU_118853_4_1_1; -.
DR InParanoid; Q8N6N7; -.
DR OMA; DINIACP; -.
DR OrthoDB; 1588000at2759; -.
DR PhylomeDB; Q8N6N7; -.
DR TreeFam; TF335802; -.
DR PathwayCommons; Q8N6N7; -.
DR Reactome; R-HSA-77289; Mitochondrial Fatty Acid Beta-Oxidation.
DR SignaLink; Q8N6N7; -.
DR BioGRID-ORCS; 414149; 17 hits in 1061 CRISPR screens.
DR EvolutionaryTrace; Q8N6N7; -.
DR GenomeRNAi; 414149; -.
DR Pharos; Q8N6N7; Tdark.
DR PRO; PR:Q8N6N7; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q8N6N7; protein.
DR Bgee; ENSG00000176244; Expressed in caudate nucleus and 100 other tissues.
DR GO; GO:0000062; F:fatty-acyl-CoA binding; IBA:GO_Central.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006631; P:fatty acid metabolic process; IBA:GO_Central.
DR Gene3D; 1.20.80.10; -; 1.
DR InterPro; IPR000582; Acyl-CoA-binding_protein.
DR InterPro; IPR035984; Acyl-CoA-binding_sf.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR Pfam; PF00887; ACBP; 1.
DR PRINTS; PR00689; ACOABINDINGP.
DR SUPFAM; SSF47027; SSF47027; 1.
DR PROSITE; PS51228; ACB_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Lipid-binding; Reference proteome.
FT CHAIN 1..88
FT /note="Acyl-CoA-binding domain-containing protein 7"
FT /id="PRO_0000247588"
FT DOMAIN 3..88
FT /note="ACB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00573"
FT BINDING 15
FT /ligand="an acyl-CoA"
FT /ligand_id="ChEBI:CHEBI:58342"
FT BINDING 30..34
FT /ligand="an acyl-CoA"
FT /ligand_id="ChEBI:CHEBI:58342"
FT BINDING 56
FT /ligand="an acyl-CoA"
FT /ligand_id="ChEBI:CHEBI:58342"
FT BINDING 75
FT /ligand="an acyl-CoA"
FT /ligand_id="ChEBI:CHEBI:58342"
FT HELIX 2..13
FT /evidence="ECO:0007829|PDB:3EPY"
FT HELIX 14..16
FT /evidence="ECO:0007829|PDB:3EPY"
FT HELIX 23..37
FT /evidence="ECO:0007829|PDB:3EPY"
FT TURN 46..49
FT /evidence="ECO:0007829|PDB:3EPY"
FT HELIX 51..61
FT /evidence="ECO:0007829|PDB:3EPY"
FT TURN 62..65
FT /evidence="ECO:0007829|PDB:3EPY"
FT HELIX 68..86
FT /evidence="ECO:0007829|PDB:3EPY"
SQ SEQUENCE 88 AA; 9790 MW; F79EFF3BD7B2138B CRC64;
MALQADFDRA AEDVRKLKAR PDDGELKELY GLYKQAIVGD INIACPGMLD LKGKAKWEAW
NLKKGLSTED ATSAYISKAK ELIEKYGI
