ID   TSAK_ORITS              Reviewed;         532 AA.
AC   P37915;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=56 kDa type-specific antigen;
DE            Short=TSA;
DE   AltName: Full=56 kDa scrub typhus antigen;
DE   AltName: Full=STA56;
DE   AltName: Full=TSK56;
DE   Flags: Precursor;
OS   Orientia tsutsugamushi (Rickettsia tsutsugamushi).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Orientia.
OX   NCBI_TaxID=784;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Karp;
RX   PubMed=1694818; DOI=10.1128/iai.58.7.2076-2084.1990;
RA   Stover C.K., Marana D.P., Carter J.M., Roe B.A., Mardis E., Oaks E.V.;
RT   "The 56-kilodalton major protein antigen of Rickettsia tsutsugamushi:
RT   molecular cloning and sequence analysis of the sta56 gene and precise
RT   identification of a strain-specific epitope.";
RL   Infect. Immun. 58:2076-2084(1990).
CC   -!- FUNCTION: May be an adherent factor for rickettsial adsorption to the
CC       host-cell surface and a determinant of virulence of individual
CC       rickettsial strain. It is the major outer membrane protein.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
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DR   EMBL; M33004; AAA26391.1; -; Genomic_DNA.
DR   PIR; B60106; B60106.
DR   AlphaFoldDB; P37915; -.
DR   PRIDE; P37915; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR011250; OMP/PagP_b-brl.
DR   InterPro; IPR004933; TSA.
DR   Pfam; PF03249; TSA; 1.
DR   PRINTS; PR01707; 56KDTSANTIGN.
DR   SUPFAM; SSF56925; SSF56925; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Signal; Transmembrane; Transmembrane helix;
KW   Virulence.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..532
FT                   /note="56 kDa type-specific antigen"
FT                   /id="PRO_0000022592"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        480..500
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          401..428
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   532 AA;  56786 MW;  B63F4BE5CF917638 CRC64;
     MKKIMLIASA MSALSLPFSA SAIELGEEGL ECGPYAKVGV VGGMITGVES ARLDPADAEG
     KKHLSLTNGL PFGGTLAAGM TIAPGFRAEI GVMYLTNITA QVEEGKVKAD SVGETKADSV
     GGKDAPIRKR FKLTPPQPTI MPISIAVRDF GIDIPNQTSA ASTSRSLRLN DEQRAAARIA
     WLKNCAGIDY RVKNPNDPNG PMVINPILLN IPQGNPNPVG NPPQRANPPA GFAIHNHEQW
     RHLVVGLAAL SNANKPSASP VKVLSDKITQ IYSDIKHLAD IAGIDVPDTS LPNSASVEQI
     QNKMQELNDL LEELRESFDG YLGGNAFANQ IQLNFVMPQQ AQQQGQGQQQ QAQATAQEAV
     AAAAVRLLNG NDQIAQLYKD LVKLQRHAGI KKAMEKLAAQ QEEDAKNQGE GDCKQQQGTS
     EKSKKGKDKE AEFDLSMIVG QVKLYADVMI TESVSIYAGV GAGLAYTSGK IDNKDIKGHT
     GMVASGALGV AINAAEGVYV DIEGSYMYSF SKIEEKYSIN PLMASVSVRY NF