TSAP1_DANRE
ID TSAP1_DANRE Reviewed; 314 AA.
AC Q503H1;
DT 01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2005, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=tRNA selenocysteine 1-associated protein 1 {ECO:0000312|ZFIN:ZDB-GENE-050522-502};
DE AltName: Full=tRNA selenocysteine-associated protein 1 {ECO:0000250|UniProtKB:Q80VC6};
GN Name=trnau1ap {ECO:0000312|ZFIN:ZDB-GENE-050522-502};
GN ORFNames=si:dkey-194c21.4, zgc:110606;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000312|EMBL:CAN88150.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000312|EMBL:AAH95331.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the early steps of selenocysteine biosynthesis
CC and tRNA(Sec) charging to the later steps resulting in the
CC cotranslational incorporation of selenocysteine into selenoproteins.
CC {ECO:0000250|UniProtKB:Q80VC6}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9QZI7}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q9QZI7}.
CC -!- SIMILARITY: Belongs to the RRM TRSPAP family. {ECO:0000255}.
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DR EMBL; BX530067; CAN88150.1; -; Genomic_DNA.
DR EMBL; BC095331; AAH95331.1; -; mRNA.
DR RefSeq; NP_001018445.1; NM_001020609.1.
DR AlphaFoldDB; Q503H1; -.
DR SMR; Q503H1; -.
DR STRING; 7955.ENSDARP00000052291; -.
DR PaxDb; Q503H1; -.
DR Ensembl; ENSDART00000158059; ENSDARP00000141333; ENSDARG00000101323.
DR GeneID; 553636; -.
DR KEGG; dre:553636; -.
DR CTD; 553636; -.
DR ZFIN; ZDB-GENE-050522-502; trnau1apa.
DR eggNOG; KOG0118; Eukaryota.
DR GeneTree; ENSGT00940000156139; -.
DR HOGENOM; CLU_016304_3_0_1; -.
DR InParanoid; Q503H1; -.
DR OMA; GYSKCCG; -.
DR OrthoDB; 775799at2759; -.
DR PhylomeDB; Q503H1; -.
DR TreeFam; TF313275; -.
DR PRO; PR:Q503H1; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 19.
DR Bgee; ENSDARG00000101323; Expressed in testis and 26 other tissues.
DR ExpressionAtlas; Q503H1; baseline and differential.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0006376; P:mRNA splice site selection; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-KW.
DR CDD; cd12612; RRM2_SECp43; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR034510; SECp43_RRM2.
DR InterPro; IPR040434; TSAP1.
DR InterPro; IPR041085; TSAP1_C.
DR PANTHER; PTHR37457; PTHR37457; 1.
DR Pfam; PF00076; RRM_1; 2.
DR Pfam; PF17654; Trnau1ap; 1.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 2.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Protein biosynthesis; Reference proteome; Repeat;
KW RNA-binding.
FT CHAIN 1..314
FT /note="tRNA selenocysteine 1-associated protein 1"
FT /id="PRO_0000382232"
FT DOMAIN 2..85
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 94..173
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
SQ SEQUENCE 314 AA; 35510 MW; 57A8C9F117978B1A CRC64;
MNSLWMGNLE PYMDEDFICR AFAQMGETVV KIRLIRDKIT GKNAGYGFVE LADDTAVERC
LRKVNGKPLP GATPPKRFKL SRSNYGKQGE SSTFSLFVSD LTPDVDDGML YEFFHYHFSS
CCSGKIVLDA NGHSKCCGFV SFESEREQKR ALVDLQGATG LGKKALRLSL ASSRVNKKKE
SSENQIWQYH SDSKNASFIN QYYYPQNLSY LSTYDWNYSL DYLNPSQNTT PVDVTQSEQT
EDDDLEYPDS EINVTEANET FMAQSEELYS ALIGCFFQPP ESWDGVTCSA SSYLPEPINQ
YEMEDSCSSN WVTT
