ID   TSAR_ORITS              Reviewed;         532 AA.
AC   P37916;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=56 kDa type-specific antigen;
DE            Short=TSA;
DE   AltName: Full=56 kDa scrub typhus antigen;
DE   AltName: Full=STA56;
DE   AltName: Full=TSR56;
DE   Flags: Precursor;
OS   Orientia tsutsugamushi (Rickettsia tsutsugamushi).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Orientia.
OX   NCBI_TaxID=784;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Kuroki;
RX   PubMed=1618776; DOI=10.1016/s0021-9258(18)42337-x;
RA   Ohashi N., Nashimoto H., Ikeda H., Tamura A.;
RT   "Diversity of immunodominant 56-kDa type-specific antigen (TSA) of
RT   Rickettsia tsutsugamushi. Sequence and comparative analyses of the genes
RT   encoding TSA homologues from four antigenic variants.";
RL   J. Biol. Chem. 267:12728-12735(1992).
CC   -!- FUNCTION: May be an adherent factor for rickettsial adsorption to the
CC       host-cell surface and a determinant of virulence of individual
CC       rickettsial strain. It is the major outer membrane protein.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
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DR   EMBL; M63380; AAA26395.1; -; Genomic_DNA.
DR   PIR; C42804; C42804.
DR   AlphaFoldDB; P37916; -.
DR   STRING; 357244.OTBS_0602; -.
DR   PRIDE; P37916; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR011250; OMP/PagP_b-brl.
DR   InterPro; IPR004933; TSA.
DR   Pfam; PF03249; TSA; 1.
DR   PRINTS; PR01707; 56KDTSANTIGN.
DR   SUPFAM; SSF56925; SSF56925; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Signal; Transmembrane; Transmembrane helix;
KW   Virulence.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..532
FT                   /note="56 kDa type-specific antigen"
FT                   /id="PRO_0000022593"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        480..500
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          113..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          400..426
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   532 AA;  56757 MW;  1989ED8EA5A82A23 CRC64;
     MKKIMLIASA MSALSLPFSA SAIELEDEVG LECGPYAKVG VVGGMITGAE STRLDSTDSE
     GKKHLSLTTG LPFGGTLAAG MTIAPGFRAE LGVMYLRNIS AEVEVGKGEV DSKGEIKADS
     GGGTDAPIRK PFKLTPPQPT MMPISIADRD FGIDIPNIPQ AQAQAAQPPL NDQKRAAARI
     AWLKNCAGID YMVKDPNNPG HMMVNPVLLN IPQGNPNPVG QPPQRANQPA NFAIHNHEQW
     RSLVVGLAAL SNANKPSASP VKVLSDKIIQ IYSDIKPFAD IAGINVPDTG LPNSASIEQI
     QSKIQELGDT LEELRDSFDG YINNAFVNQI HLNFVMPPQA QQQQGQGQQQ QAQATAQEAV
     AAAAVRLLNG SDQIAQLYKD LVKLQRHAGI RKAMEKLAAQ QEEDAKNQGK GDCKQQQGAS
     EKSKEGKVKE TEFDLSMVVG QVKLYADLVT TESFSIYGGV GAGLAYTYGK IDNKDVKGYT
     GMVASGALGV AINAAEGVCV DLEAGYMHSF SKVEDKYQVN AFIASACVRY NF