ID   TSAS_ORITS              Reviewed;         521 AA.
AC   P37917;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=56 kDa type-specific antigen;
DE            Short=TSA;
DE   AltName: Full=56 kDa scrub typhus antigen;
DE   AltName: Full=STA56;
DE   AltName: Full=TSS56;
DE   Flags: Precursor;
OS   Orientia tsutsugamushi (Rickettsia tsutsugamushi).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Orientia.
OX   NCBI_TaxID=784;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Shimokoshi;
RX   PubMed=1618776; DOI=10.1016/s0021-9258(18)42337-x;
RA   Ohashi N., Nashimoto H., Ikeda H., Tamura A.;
RT   "Diversity of immunodominant 56-kDa type-specific antigen (TSA) of
RT   Rickettsia tsutsugamushi. Sequence and comparative analyses of the genes
RT   encoding TSA homologues from four antigenic variants.";
RL   J. Biol. Chem. 267:12728-12735(1992).
CC   -!- FUNCTION: May be an adherent factor for rickettsial adsorption to the
CC       host-cell surface and a determinant of virulence of individual
CC       rickettsial strain. It is the major outer membrane protein.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
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DR   EMBL; M63381; AAA26396.1; -; Genomic_DNA.
DR   PIR; D42804; D42804.
DR   AlphaFoldDB; P37917; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR011250; OMP/PagP_b-brl.
DR   InterPro; IPR004933; TSA.
DR   Pfam; PF03249; TSA; 1.
DR   PRINTS; PR01707; 56KDTSANTIGN.
DR   SUPFAM; SSF56925; SSF56925; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Signal; Transmembrane; Transmembrane helix;
KW   Virulence.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..521
FT                   /note="56 kDa type-specific antigen"
FT                   /id="PRO_0000022594"
FT   TRANSMEM        64..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        469..484
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          386..415
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        394..415
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   521 AA;  55311 MW;  37E5EE4CF486A01D CRC64;
     MRKIMLIASA MSALSLPFSA NAIEFDENSL ECGPYAKVGI VGGVLSGVES ARLDPADSEG
     KKHLPLIKGM PFGVTLAAGM TITPGVRAEI SAMYLMNVKA EVELGKMGSD ANTGTTADAS
     AGVIRKHKKL TPPQPNIMPI SIADRDIAVD IPNAAGQGNV DVRAAARIAW LKNYAGIDYY
     VPDSNNPQGR VVNPVLLNIP QGNPNPAGGG GRAAPAAFDI LDHAQWRDVV VGITALSNAN
     KPNVSAVKIL SDKISQIYAD IKPFANVASV QISETPLPDS ASVDQIQNKV QELNKVLEDV
     RESFDGFILN AFAQPVRLNF QIPQVVQGQG QQPQAAATAQ EAAAAAAIRA LNDGENNGII
     QLYKDLYKLQ RNVALKKSMK QLGDELGVDQ GQEGGCSKDK KQSDTTAEES KKEGKKGKEI
     EFDLHMAVGQ VKLYADLFTI DSFSVYAGIG AGLAYTHGKI DGKDIKAHTG MVGSLALGVA
     ANVADGVYMD VDAGYLYSFS KIEEKYQMNA FVASAGIRYN F