ID   TSAW_ORITS              Reviewed;         522 AA.
AC   P37919;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=56 kDa type-specific antigen;
DE            Short=TSA;
DE   AltName: Full=56 kDa scrub typhus antigen;
DE   AltName: Full=STA56;
DE   AltName: Full=TSW56;
DE   Flags: Precursor;
OS   Orientia tsutsugamushi (Rickettsia tsutsugamushi).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Orientia.
OX   NCBI_TaxID=784;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Kawasaki;
RX   PubMed=1618776; DOI=10.1016/s0021-9258(18)42337-x;
RA   Ohashi N., Nashimoto H., Ikeda H., Tamura A.;
RT   "Diversity of immunodominant 56-kDa type-specific antigen (TSA) of
RT   Rickettsia tsutsugamushi. Sequence and comparative analyses of the genes
RT   encoding TSA homologues from four antigenic variants.";
RL   J. Biol. Chem. 267:12728-12735(1992).
CC   -!- FUNCTION: May be an adherent factor for rickettsial adsorption to the
CC       host-cell surface and a determinant of virulence of individual
CC       rickettsial strain. It is the major outer membrane protein.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
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DR   EMBL; M63383; AAA26398.1; -; Genomic_DNA.
DR   PIR; B42804; B42804.
DR   AlphaFoldDB; P37919; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR011250; OMP/PagP_b-brl.
DR   InterPro; IPR004933; TSA.
DR   Pfam; PF03249; TSA; 1.
DR   PRINTS; PR01707; 56KDTSANTIGN.
DR   SUPFAM; SSF56925; SSF56925; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Signal; Transmembrane; Transmembrane helix;
KW   Virulence.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..522
FT                   /note="56 kDa type-specific antigen"
FT                   /id="PRO_0000022596"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        470..490
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          385..417
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        403..417
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   522 AA;  55972 MW;  64CB0E3B1B5A2EB6 CRC64;
     MKKIMLIASA MSALSLPFSA SAIELGDEGV LECGPYAKIG VVGGMVTGVE SARLDPADVD
     CKKHLSLTTM LPFGGTLAAG MTIAPGFRAE LGVMYLRNIN AEVELGEGKT GSGAANAAID
     TGAPIRKRFK LTPPQPTIMP ISIADRDLGV DTDILAQAAV GQQQLTVEQR AEDRIAWLKN
     YAGIDYMVPD SQNPNARVVN PVLLNITQGA PNVNPRPRQN LNILDHDQWR YLVVGVTALS
     NANKPSVSSV KVLSDKITQI YSDIRQFAKI ANIEVPGAPL PNSASVEQIQ TKMQELNDVL
     EELRESFDGY LANAFANQIQ LNFQIQQAQQ QQQQQQQGQV TAQEAAAAAA VRALNGNEQI
     IQLYKDLVKL QRHAGIRKAM EKLAAQEEGD DQSQVSCNDK KQQAVAEDSK AGSSKEGKNK
     EVELDLSMIV AQVKLYADVV ATESFSIYIG GGVGVARTYG DIDGKSVKHI GVVASGVLGV
     AINVADGVCV DIDGGYMHSF SKIEDKYSVN AFIANAGVRY NF