C3H57_ARATH
ID C3H57_ARATH Reviewed; 375 AA.
AC Q8L7N8; Q27GJ0; Q8LFU7; Q9XFB9;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Zinc finger CCCH domain-containing protein 57;
DE Short=AtC3H57;
DE AltName: Full=Zinc finger type domain-containing protein ZFN3;
GN Name=ZFN3; OrderedLocusNames=At5g16540; ORFNames=MQK4.29;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RA Choi S., Lee J., Yi H., Shin B., Choi G.;
RT "Characterization of zinc finger protein 3 (ZFN-3) in Arabidopsis
RT thaliana.";
RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9330910; DOI=10.1093/dnares/4.3.215;
RA Sato S., Kotani H., Nakamura Y., Kaneko T., Asamizu E., Fukami M.,
RA Miyajima N., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. I. Sequence
RT features of the 1.6 Mb regions covered by twenty physically assigned P1
RT clones.";
RL DNA Res. 4:215-230(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 281-375 (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC STRAIN=cv. Columbia;
RX PubMed=14993207; DOI=10.1101/gr.1515604;
RA Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA Weissenbach J., Salanoubat M.;
RT "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT combined approach to evaluate and improve Arabidopsis genome annotation.";
RL Genome Res. 14:406-413(2004).
RN [7]
RP NOMENCLATURE.
RX PubMed=18221561; DOI=10.1186/1471-2164-9-44;
RA Wang D., Guo Y., Wu C., Yang G., Li Y., Zheng C.;
RT "Genome-wide analysis of CCCH zinc finger family in Arabidopsis and rice.";
RL BMC Genomics 9:44-44(2008).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8L7N8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8L7N8-2; Sequence=VSP_013558;
CC Name=3;
CC IsoId=Q8L7N8-3; Sequence=VSP_037122;
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to a competing donor splice
CC site. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 3]: May be due to intron retention.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM61197.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF138872; AAD27875.1; -; mRNA.
DR EMBL; AB005242; BAB09623.1; -; Genomic_DNA.
DR EMBL; CP002688; AED92306.1; -; Genomic_DNA.
DR EMBL; CP002688; AED92307.1; -; Genomic_DNA.
DR EMBL; CP002688; AED92308.1; -; Genomic_DNA.
DR EMBL; AY084634; AAM61197.1; ALT_INIT; mRNA.
DR EMBL; AY128342; AAM91545.1; -; mRNA.
DR EMBL; BT000014; AAN15333.1; -; mRNA.
DR EMBL; BX831982; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_568332.2; NM_121660.4. [Q8L7N8-2]
DR RefSeq; NP_851041.1; NM_180710.3. [Q8L7N8-1]
DR RefSeq; NP_974790.1; NM_203061.2. [Q8L7N8-3]
DR AlphaFoldDB; Q8L7N8; -.
DR BioGRID; 16792; 2.
DR IntAct; Q8L7N8; 2.
DR STRING; 3702.AT5G16540.1; -.
DR PaxDb; Q8L7N8; -.
DR PRIDE; Q8L7N8; -.
DR ProteomicsDB; 240560; -. [Q8L7N8-1]
DR EnsemblPlants; AT5G16540.1; AT5G16540.1; AT5G16540. [Q8L7N8-1]
DR EnsemblPlants; AT5G16540.2; AT5G16540.2; AT5G16540. [Q8L7N8-2]
DR EnsemblPlants; AT5G16540.3; AT5G16540.3; AT5G16540. [Q8L7N8-3]
DR GeneID; 831516; -.
DR Gramene; AT5G16540.1; AT5G16540.1; AT5G16540. [Q8L7N8-1]
DR Gramene; AT5G16540.2; AT5G16540.2; AT5G16540. [Q8L7N8-2]
DR Gramene; AT5G16540.3; AT5G16540.3; AT5G16540. [Q8L7N8-3]
DR KEGG; ath:AT5G16540; -.
DR Araport; AT5G16540; -.
DR TAIR; locus:2171407; AT5G16540.
DR eggNOG; KOG1677; Eukaryota.
DR InParanoid; Q8L7N8; -.
DR OrthoDB; 657700at2759; -.
DR PhylomeDB; Q8L7N8; -.
DR PRO; PR:Q8L7N8; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q8L7N8; baseline and differential.
DR Genevisible; Q8L7N8; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; TAS:TAIR.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003729; F:mRNA binding; IDA:TAIR.
DR GO; GO:0004518; F:nuclease activity; TAS:TAIR.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR036855; Znf_CCCH_sf.
DR Pfam; PF00642; zf-CCCH; 5.
DR SMART; SM00356; ZnF_C3H1; 5.
DR SUPFAM; SSF90229; SSF90229; 5.
DR PROSITE; PS50103; ZF_C3H1; 5.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..375
FT /note="Zinc finger CCCH domain-containing protein 57"
FT /id="PRO_0000213914"
FT ZN_FING 42..70
FT /note="C3H1-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 87..115
FT /note="C3H1-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 133..161
FT /note="C3H1-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 243..271
FT /note="C3H1-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 289..317
FT /note="C3H1-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT REGION 352..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..21
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14993207"
FT /id="VSP_037122"
FT VAR_SEQ 284..290
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_013558"
SQ SEQUENCE 375 AA; 41526 MW; 35EF3CDEB693170A CRC64;
MDFDSISRES TFLSPLLNQN AMWQMNLGSD DTMGVDGSYP ERHGEPDCAY YIRTGLCRFG
STCRFNHPHD RKLVIATARI KGEYPERIGQ PECEFYLKTG TCKFGVTCKF HHPRNKAGID
GSVSVNVLSY PLRPNEDDCS YFLRIGQCKF GGTCKFNHPQ TQSTNLMVSV RGSPVYSALQ
SLTGQPSYSW SRTSFVANPP RLQDPSGFAS GSQGGLFSSG FHSGNSVPLG FYALPRENVF
PERPGQPECQ FYMKTGDCKF GTVCKFHHPR DRQTPPPDCV LSSVGLPLRP GEPLCVFYSR
YGICKFGPSC KFDHPMRVFT YNNNTASPSP SSSLHQETAI TTELRNLLVS SSVEAKPTSL
PETTSAKDTI VDAQH
