ID   TSC3_ASHGO              Reviewed;         107 AA.
AC   Q750C9;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Serine palmitoyltransferase-regulating protein TSC3;
GN   Name=TSC3; OrderedLocusNames=AGR026C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Stimulates the activity of serine palmitoyltransferase (SPT).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
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DR   EMBL; AE016820; AAS54515.1; -; Genomic_DNA.
DR   RefSeq; NP_986691.1; NM_211753.1.
DR   AlphaFoldDB; Q750C9; -.
DR   SMR; Q750C9; -.
DR   STRING; 33169.AAS54515; -.
DR   EnsemblFungi; AAS54515; AAS54515; AGOS_AGR026C.
DR   GeneID; 4622990; -.
DR   KEGG; ago:AGOS_AGR026C; -.
DR   eggNOG; ENOG502S91C; Eukaryota.
DR   HOGENOM; CLU_176405_0_0_1; -.
DR   InParanoid; Q750C9; -.
DR   OMA; YYVHLPF; -.
DR   Proteomes; UP000000591; Chromosome VII.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0035339; C:SPOTS complex; IEA:EnsemblFungi.
DR   GO; GO:0008047; F:enzyme activator activity; IEA:EnsemblFungi.
DR   GO; GO:0006666; P:3-keto-sphinganine metabolic process; IEA:EnsemblFungi.
DR   GO; GO:0090154; P:positive regulation of sphingolipid biosynthetic process; IEA:EnsemblFungi.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..107
FT                   /note="Serine palmitoyltransferase-regulating protein TSC3"
FT                   /id="PRO_0000076356"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   107 AA;  12532 MW;  24BC438A852047E7 CRC64;
     MMAADDTMSS KRADNCYKKD RGTMVYTPTD AQQATGKVHE KVYKFFESLY WMYYIHLPYY
     LMTSFDSFCL HVFFLVVFTL SLFGLLKWVL SLYWATVGYM AYAATGQ