ID   TSC3_KLULA              Reviewed;          84 AA.
AC   Q6CJH4;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Serine palmitoyltransferase-regulating protein TSC3;
GN   Name=TSC3; OrderedLocusNames=KLLA0F18634g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Stimulates the activity of serine palmitoyltransferase (SPT).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
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DR   EMBL; CR382126; CAG98623.1; -; Genomic_DNA.
DR   RefSeq; XP_455915.1; XM_455915.1.
DR   AlphaFoldDB; Q6CJH4; -.
DR   SMR; Q6CJH4; -.
DR   STRING; 28985.XP_455915.1; -.
DR   EnsemblFungi; CAG98623; CAG98623; KLLA0_F18634g.
DR   GeneID; 2895557; -.
DR   KEGG; kla:KLLA0_F18634g; -.
DR   eggNOG; ENOG502S91C; Eukaryota.
DR   HOGENOM; CLU_176405_0_0_1; -.
DR   InParanoid; Q6CJH4; -.
DR   OMA; YYVHLPF; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0035339; C:SPOTS complex; IEA:EnsemblFungi.
DR   GO; GO:0008047; F:enzyme activator activity; IEA:EnsemblFungi.
DR   GO; GO:0006666; P:3-keto-sphinganine metabolic process; IEA:EnsemblFungi.
DR   GO; GO:0090154; P:positive regulation of sphingolipid biosynthetic process; IEA:EnsemblFungi.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..84
FT                   /note="Serine palmitoyltransferase-regulating protein TSC3"
FT                   /id="PRO_0000076357"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   84 AA;  9813 MW;  6E337FACABA18774 CRC64;
     MAAEKIYEPY KKSRGTMIYT PTNQQMSRGG IGEKLADFVK NLYWVYYIHL PFYLMTSLDA
     FCLHTIFLVV VSLSLFGLLK YIFL