TSCOT_CANLF
ID TSCOT_CANLF Reviewed; 481 AA.
AC Q866G7; Q863C5;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Thymic stromal cotransporter homolog;
DE AltName: Full=CE11;
DE AltName: Full=Solute carrier family 46 member 2;
GN Name=SLC46A2; Synonyms=TSCOT;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), POSSIBLE FUNCTION, AND
RP TISSUE SPECIFICITY.
RC TISSUE=Epididymis;
RX PubMed=12826694; DOI=10.1002/j.1939-4640.2003.tb02706.x;
RA Obermann H., Wingbermuhle A., Munz S., Kirchhoff C.;
RT "A putative 12-transmembrane domain cotransporter associated with apical
RT membranes of the epididymal duct.";
RL J. Androl. 24:542-556(2003).
CC -!- FUNCTION: May act as a transporter (By similarity). May be involved in
CC establishing and maintaining the luminal fluid microenvironment.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}. Note=Apical membranes of organs.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q866G7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q866G7-2; Sequence=VSP_012656, VSP_012657;
CC -!- TISSUE SPECIFICITY: Highly expressed by the epididymal duct epithelium.
CC {ECO:0000269|PubMed:12826694}.
CC -!- PTM: Glycosylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. SLC46A
CC family. {ECO:0000305}.
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DR EMBL; AY195876; AAO23670.1; -; mRNA.
DR EMBL; AY225149; AAO65959.1; -; mRNA.
DR RefSeq; NP_001002997.1; NM_001002997.1. [Q866G7-1]
DR AlphaFoldDB; Q866G7; -.
DR SMR; Q866G7; -.
DR STRING; 9612.ENSCAFP00000004557; -.
DR PaxDb; Q866G7; -.
DR Ensembl; ENSCAFT00030045438; ENSCAFP00030039682; ENSCAFG00030024680. [Q866G7-1]
DR Ensembl; ENSCAFT00040029685; ENSCAFP00040025787; ENSCAFG00040016120. [Q866G7-1]
DR Ensembl; ENSCAFT00845012546; ENSCAFP00845009800; ENSCAFG00845006936. [Q866G7-1]
DR GeneID; 403501; -.
DR KEGG; cfa:403501; -.
DR CTD; 57864; -.
DR VEuPathDB; HostDB:ENSCAFG00845006936; -.
DR eggNOG; KOG2816; Eukaryota.
DR GeneTree; ENSGT00950000183096; -.
DR InParanoid; Q866G7; -.
DR OrthoDB; 763423at2759; -.
DR Proteomes; UP000002254; Chromosome 11.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0070233; P:negative regulation of T cell apoptotic process; IEA:Ensembl.
DR GO; GO:0070430; P:positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway; IEA:Ensembl.
DR GO; GO:0045580; P:regulation of T cell differentiation; IEA:Ensembl.
DR GO; GO:0043029; P:T cell homeostasis; IEA:Ensembl.
DR GO; GO:0048538; P:thymus development; IEA:Ensembl.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR001958; Tet-R_TetA/multi-R_MdtG.
DR Pfam; PF07690; MFS_1; 1.
DR PRINTS; PR01035; TCRTETA.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Glycoprotein; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..481
FT /note="Thymic stromal cotransporter homolog"
FT /id="PRO_0000065658"
FT TOPO_DOM 1..37
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 59..83
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 105..113
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 135..143
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..179
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 201..210
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 232..286
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 308..326
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 327..347
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 348..353
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 354..374
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 375..376
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 377..397
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 398..412
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..433
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 434..446
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 447..467
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 468..481
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 263..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 61
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 326..347
FT /note="VGYGMAAGYTIFITSFLGVLVF -> LEPSCCSLSSLSQPSGQQCPNS (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:12826694"
FT /id="VSP_012656"
FT VAR_SEQ 348..481
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12826694"
FT /id="VSP_012657"
SQ SEQUENCE 481 AA; 50701 MW; 73718554890E9A3F CRC64;
MGPEAAGPGR GAAPRLQVRT WIEPVVAATQ VASSLYEAGL LLVVKASFGA GAGAGAGAAS
NHSAGPPRGA PEDQQQRAIS NFYIVYNLVV GLTPLLSAYA LGWLSDRRHR KVAICVALLG
FLLSRVGLLL KVLLDWPVEV LYGAAALNGL CGGFSAFWAG VMALGSLGSS EGRRSVRLVL
IDLILGLAGF CGSMASGHLF KQVAGHSGQG LVLTACSVSC ATFALLYSLL VLKVPEAAAG
SGQALSAGDS VAGTVGTYRT LDPDHSDKQS VQGLHPPSPG KAKPRRTIIA LLFLGAIVYD
LAVVGTVDVM PLFVLREPLS WNQVQVGYGM AAGYTIFITS FLGVLVFSRC FQDTTMIMIG
MVSFGSGALL LAFVKETYMF YIARAVMLFA LIPITTIRSA MSKLIKGSSY GKVFVILQLS
LTLTGVVTST VYNKIYQVTM EKFIGTCFAL SSFLSFLAII PIGIVAYKQA SWLQYGDVRE
T
