TSCOT_HUMAN
ID TSCOT_HUMAN Reviewed; 475 AA.
AC Q9BY10; B1ALK1; Q86VT0; Q96NE2;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Thymic stromal cotransporter homolog;
DE AltName: Full=Solute carrier family 46 member 2;
GN Name=SLC46A2; Synonyms=TSCOT;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Thymus;
RX PubMed=10978518; DOI=10.1016/s0167-4781(00)00177-9;
RA Chen C., Kim M.G., Lyu M.S., Kozak C.A., Schwartz R.H., Flomerfelt F.A.;
RT "Characterization of the mouse gene, human promoter and human cDNA of TSCOT
RT reveals strong interspecies homology.";
RL Biochim. Biophys. Acta 1493:159-169(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Blood;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May act as a transporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Strongly expressed in the adult thymus. Expressed
CC in spleen, lymph nodes, thymus, PBL, bone marrow and fetal liver.
CC {ECO:0000269|PubMed:10978518}.
CC -!- PTM: Glycosylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. SLC46A
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF242557; AAK28343.1; -; mRNA.
DR EMBL; AK055571; BAB70960.1; -; mRNA.
DR EMBL; AK314414; BAG37035.1; -; mRNA.
DR EMBL; AL139041; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH878453; EAW50550.1; -; Genomic_DNA.
DR EMBL; BC048285; AAH48285.1; -; mRNA.
DR CCDS; CCDS6786.1; -.
DR RefSeq; NP_149040.3; NM_033051.3.
DR AlphaFoldDB; Q9BY10; -.
DR SMR; Q9BY10; -.
DR STRING; 9606.ENSP00000363345; -.
DR TCDB; 2.A.1.50.2; the major facilitator superfamily (mfs).
DR GlyGen; Q9BY10; 1 site.
DR iPTMnet; Q9BY10; -.
DR PhosphoSitePlus; Q9BY10; -.
DR BioMuta; SLC46A2; -.
DR DMDM; 83287921; -.
DR MassIVE; Q9BY10; -.
DR MaxQB; Q9BY10; -.
DR PaxDb; Q9BY10; -.
DR PeptideAtlas; Q9BY10; -.
DR PRIDE; Q9BY10; -.
DR Antibodypedia; 29714; 59 antibodies from 18 providers.
DR DNASU; 57864; -.
DR Ensembl; ENST00000374228.5; ENSP00000363345.4; ENSG00000119457.8.
DR GeneID; 57864; -.
DR KEGG; hsa:57864; -.
DR MANE-Select; ENST00000374228.5; ENSP00000363345.4; NM_033051.4; NP_149040.3.
DR UCSC; uc004bgk.3; human.
DR CTD; 57864; -.
DR DisGeNET; 57864; -.
DR GeneCards; SLC46A2; -.
DR HGNC; HGNC:16055; SLC46A2.
DR HPA; ENSG00000119457; Tissue enhanced (cervix, lung, lymphoid tissue, skin).
DR MIM; 608956; gene.
DR neXtProt; NX_Q9BY10; -.
DR OpenTargets; ENSG00000119457; -.
DR PharmGKB; PA162403790; -.
DR VEuPathDB; HostDB:ENSG00000119457; -.
DR eggNOG; KOG2816; Eukaryota.
DR GeneTree; ENSGT00950000183096; -.
DR HOGENOM; CLU_028365_3_0_1; -.
DR InParanoid; Q9BY10; -.
DR OMA; AYWSGVM; -.
DR OrthoDB; 763423at2759; -.
DR PhylomeDB; Q9BY10; -.
DR TreeFam; TF315701; -.
DR PathwayCommons; Q9BY10; -.
DR BioGRID-ORCS; 57864; 8 hits in 1062 CRISPR screens.
DR GenomeRNAi; 57864; -.
DR Pharos; Q9BY10; Tdark.
DR PRO; PR:Q9BY10; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q9BY10; protein.
DR Bgee; ENSG00000119457; Expressed in upper arm skin and 91 other tissues.
DR ExpressionAtlas; Q9BY10; baseline and differential.
DR Genevisible; Q9BY10; HS.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; NAS:UniProtKB.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0070233; P:negative regulation of T cell apoptotic process; IEA:Ensembl.
DR GO; GO:0070430; P:positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway; IMP:FlyBase.
DR GO; GO:0045580; P:regulation of T cell differentiation; IEA:Ensembl.
DR GO; GO:0043029; P:T cell homeostasis; IEA:Ensembl.
DR GO; GO:0048538; P:thymus development; IEA:Ensembl.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR001958; Tet-R_TetA/multi-R_MdtG.
DR Pfam; PF07690; MFS_1; 1.
DR PRINTS; PR01035; TCRTETA.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..475
FT /note="Thymic stromal cotransporter homolog"
FT /id="PRO_0000065659"
FT TOPO_DOM 1..23
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..78
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 100..108
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..138
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..172
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 194..205
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227..282
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..303
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 304..320
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 321..341
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 342..347
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 348..368
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 369..370
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 371..391
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 392..406
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 407..427
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 428..435
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 436..456
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 457..475
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 55
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 366
FT /note="A -> V (in dbSNP:rs16917454)"
FT /id="VAR_021050"
FT CONFLICT 26
FT /note="V -> M (in Ref. 5; AAH48285)"
FT /evidence="ECO:0000305"
FT CONFLICT 380
FT /note="V -> A (in Ref. 2; BAB70960)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 475 AA; 51067 MW; 3C4DDD6C48356054 CRC64;
MSPEVTCPRR GHLPRFHPRT WVEPVVASSQ VAASLYDAGL LLVVKASYGT GGSSNHSASP
SPRGALEDQQ QRAISNFYII YNLVVGLSPL LSAYGLGWLS DRYHRKISIC MSLLGFLLSR
LGLLLKVLLD WPVEVLYGAA ALNGLFGGFS AFWSGVMALG SLGSSEGRRS VRLILIDLML
GLAGFCGSMA SGHLFKQMAG HSGQGLILTA CSVSCASFAL LYSLLVLKVP ESVAKPSQEL
PAVDTVSGTV GTYRTLDPDQ LDQQYAVGHP PSPGKAKPHK TTIALLFVGA IIYDLAVVGT
VDVIPLFVLR EPLGWNQVQV GYGMAAGYTI FITSFLGVLV FSRCFRDTTM IMIGMVSFGS
GALLLAFVKE TYMFYIARAV MLFALIPVTT IRSAMSKLIK GSSYGKVFVI LQLSLALTGV
VTSTLYNKIY QLTMDMFVGS CFALSSFLSF LAIIPISIVA YKQVPLSPYG DIIEK
