TSG10_HUMAN
ID TSG10_HUMAN Reviewed; 698 AA.
AC Q9BZW7; B7Z925; D3DVH7; Q8NEP0; Q9BWX0;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Testis-specific gene 10 protein;
DE AltName: Full=Testis development protein NYD-SP7;
GN Name=TSGA10; Synonyms=CEP4L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC TISSUE=Testis;
RX PubMed=11179690; DOI=10.1016/s0378-1119(00)00519-9;
RA Modarressi M.H., Cameron J., Taylor K.E., Wolfe J.;
RT "Identification and characterisation of a novel gene, TSGA10, expressed in
RT testis.";
RL Gene 262:249-255(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RA Sha J.H., Zhou Z.M.;
RT "NYD-SP7: a novel gene related to human testis development.";
RL Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP TISSUE SPECIFICITY.
RX PubMed=14585816; DOI=10.1095/biolreprod.103.021170;
RA Modarressi M.H., Behnam B., Cheng M., Taylor K.E., Wolfe J.,
RA van der Hoorn F.A.;
RT "Tsga10 encodes a 65-kilodalton protein that is processed to the 27-
RT kilodalton fibrous sheath protein.";
RL Biol. Reprod. 70:608-615(2004).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [9]
RP INVOLVEMENT IN SPGF26, FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=28905369; DOI=10.1111/cge.13140;
RA Sha Y.W., Sha Y.K., Ji Z.Y., Mei L.B., Ding L., Zhang Q., Qiu P.P.,
RA Lin S.B., Wang X., Li P., Xu X., Li L.;
RT "TSGA10 is a novel candidate gene associated with acephalic spermatozoa.";
RL Clin. Genet. 93:776-783(2018).
CC -!- FUNCTION: Plays a role in spermatogenesis (PubMed:28905369). When
CC overexpressed, prevents nuclear localization of HIF1A (By similarity).
CC {ECO:0000250|UniProtKB:Q6NY15, ECO:0000269|PubMed:28905369}.
CC -!- SUBUNIT: Interacts with HIF1A. {ECO:0000250|UniProtKB:Q6NY15}.
CC -!- INTERACTION:
CC Q9BZW7; Q4LEZ3: AARD; NbExp=3; IntAct=EBI-744794, EBI-5463075;
CC Q9BZW7; A0A0S2Z4M1: AXIN1; NbExp=3; IntAct=EBI-744794, EBI-16429430;
CC Q9BZW7; Q9Y2T1: AXIN2; NbExp=3; IntAct=EBI-744794, EBI-4400025;
CC Q9BZW7; A8KA13: BCL6B; NbExp=3; IntAct=EBI-744794, EBI-10174813;
CC Q9BZW7; Q13490: BIRC2; NbExp=4; IntAct=EBI-744794, EBI-514538;
CC Q9BZW7; Q9HC52: CBX8; NbExp=3; IntAct=EBI-744794, EBI-712912;
CC Q9BZW7; Q8NA61: CBY2; NbExp=3; IntAct=EBI-744794, EBI-741724;
CC Q9BZW7; A6NC98: CCDC88B; NbExp=3; IntAct=EBI-744794, EBI-347573;
CC Q9BZW7; Q8TD31-3: CCHCR1; NbExp=6; IntAct=EBI-744794, EBI-10175300;
CC Q9BZW7; Q6P1J9: CDC73; NbExp=8; IntAct=EBI-744794, EBI-930143;
CC Q9BZW7; Q07002: CDK18; NbExp=3; IntAct=EBI-744794, EBI-746238;
CC Q9BZW7; Q9C0F1: CEP44; NbExp=6; IntAct=EBI-744794, EBI-744115;
CC Q9BZW7; Q86XR8-3: CEP57; NbExp=3; IntAct=EBI-744794, EBI-11752486;
CC Q9BZW7; Q8IYX8-2: CEP57L1; NbExp=3; IntAct=EBI-744794, EBI-10181988;
CC Q9BZW7; Q9Y2V7: COG6; NbExp=3; IntAct=EBI-744794, EBI-3866319;
CC Q9BZW7; Q02930-3: CREB5; NbExp=3; IntAct=EBI-744794, EBI-10192698;
CC Q9BZW7; Q9NRI5-2: DISC1; NbExp=3; IntAct=EBI-744794, EBI-11988027;
CC Q9BZW7; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-744794, EBI-7225287;
CC Q9BZW7; Q8TES7-6: FBF1; NbExp=3; IntAct=EBI-744794, EBI-10244131;
CC Q9BZW7; C0H5X2: FLJ38668; NbExp=3; IntAct=EBI-744794, EBI-10176227;
CC Q9BZW7; Q08379: GOLGA2; NbExp=3; IntAct=EBI-744794, EBI-618309;
CC Q9BZW7; P56524-2: HDAC4; NbExp=3; IntAct=EBI-744794, EBI-11953488;
CC Q9BZW7; Q7Z353: HDX; NbExp=3; IntAct=EBI-744794, EBI-1052734;
CC Q9BZW7; P52272: HNRNPM; NbExp=3; IntAct=EBI-744794, EBI-486809;
CC Q9BZW7; Q96ED9-2: HOOK2; NbExp=3; IntAct=EBI-744794, EBI-10961706;
CC Q9BZW7; O75564-2: JRK; NbExp=3; IntAct=EBI-744794, EBI-17181882;
CC Q9BZW7; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-744794, EBI-2556193;
CC Q9BZW7; Q86T90: KIAA1328; NbExp=3; IntAct=EBI-744794, EBI-3437878;
CC Q9BZW7; Q01546: KRT76; NbExp=3; IntAct=EBI-744794, EBI-2952745;
CC Q9BZW7; Q9Y250: LZTS1; NbExp=3; IntAct=EBI-744794, EBI-1216080;
CC Q9BZW7; Q9Y6D9: MAD1L1; NbExp=3; IntAct=EBI-744794, EBI-742610;
CC Q9BZW7; P43243: MATR3; NbExp=3; IntAct=EBI-744794, EBI-352602;
CC Q9BZW7; Q8WWY6: MBD3L1; NbExp=3; IntAct=EBI-744794, EBI-12516603;
CC Q9BZW7; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-744794, EBI-10172526;
CC Q9BZW7; Q15742: NAB2; NbExp=3; IntAct=EBI-744794, EBI-8641936;
CC Q9BZW7; Q9P286: PAK5; NbExp=3; IntAct=EBI-744794, EBI-741896;
CC Q9BZW7; Q4G0R1: PIBF1; NbExp=3; IntAct=EBI-744794, EBI-14066006;
CC Q9BZW7; Q16512: PKN1; NbExp=3; IntAct=EBI-744794, EBI-602382;
CC Q9BZW7; Q6IQ23-2: PLEKHA7; NbExp=3; IntAct=EBI-744794, EBI-12069346;
CC Q9BZW7; Q8NEY8: PPHLN1; NbExp=3; IntAct=EBI-744794, EBI-474076;
CC Q9BZW7; Q96KQ4: PPP1R13B; NbExp=3; IntAct=EBI-744794, EBI-1105153;
CC Q9BZW7; Q6NYC8: PPP1R18; NbExp=3; IntAct=EBI-744794, EBI-2557469;
CC Q9BZW7; Q9GZV8: PRDM14; NbExp=3; IntAct=EBI-744794, EBI-3957793;
CC Q9BZW7; Q9NQX0: PRDM6; NbExp=3; IntAct=EBI-744794, EBI-11320284;
CC Q9BZW7; Q8WWY3: PRPF31; NbExp=6; IntAct=EBI-744794, EBI-1567797;
CC Q9BZW7; Q9NYW8: RBAK; NbExp=3; IntAct=EBI-744794, EBI-1210429;
CC Q9BZW7; Q9P2K3: RCOR3; NbExp=3; IntAct=EBI-744794, EBI-743428;
CC Q9BZW7; A0A0S2Z4G9: RNF6; NbExp=3; IntAct=EBI-744794, EBI-16428950;
CC Q9BZW7; Q14D33: RTP5; NbExp=3; IntAct=EBI-744794, EBI-10217913;
CC Q9BZW7; O95171: SCEL; NbExp=3; IntAct=EBI-744794, EBI-7543896;
CC Q9BZW7; O60504: SORBS3; NbExp=3; IntAct=EBI-744794, EBI-741237;
CC Q9BZW7; Q5T7P8-2: SYT6; NbExp=3; IntAct=EBI-744794, EBI-10246152;
CC Q9BZW7; Q15560: TCEA2; NbExp=3; IntAct=EBI-744794, EBI-710310;
CC Q9BZW7; Q08117: TLE5; NbExp=3; IntAct=EBI-744794, EBI-717810;
CC Q9BZW7; Q05BL1: TP53BP2; NbExp=3; IntAct=EBI-744794, EBI-11952721;
CC Q9BZW7; Q14142: TRIM14; NbExp=3; IntAct=EBI-744794, EBI-2820256;
CC Q9BZW7; O43167: ZBTB24; NbExp=3; IntAct=EBI-744794, EBI-744471;
CC Q9BZW7; Q9HCK0: ZBTB26; NbExp=3; IntAct=EBI-744794, EBI-3918996;
CC Q9BZW7; O15060: ZBTB39; NbExp=3; IntAct=EBI-744794, EBI-9995672;
CC Q9BZW7; Q15973: ZNF124; NbExp=3; IntAct=EBI-744794, EBI-2555767;
CC Q9BZW7; Q9BSG1-2: ZNF2; NbExp=3; IntAct=EBI-744794, EBI-10297542;
CC Q9BZW7; O95201: ZNF205; NbExp=3; IntAct=EBI-744794, EBI-747343;
CC Q9BZW7; P17027: ZNF23; NbExp=3; IntAct=EBI-744794, EBI-5657766;
CC Q9BZW7; Q86VK4: ZNF410; NbExp=3; IntAct=EBI-744794, EBI-720304;
CC Q9BZW7; Q86VK4-3: ZNF410; NbExp=3; IntAct=EBI-744794, EBI-11741890;
CC Q9BZW7; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-744794, EBI-740727;
CC Q9BZW7; Q9BUY5: ZNF426; NbExp=3; IntAct=EBI-744794, EBI-743265;
CC Q9BZW7; Q7Z4V0: ZNF438; NbExp=3; IntAct=EBI-744794, EBI-11962468;
CC Q9BZW7; Q9ULM2: ZNF490; NbExp=3; IntAct=EBI-744794, EBI-1105370;
CC Q9BZW7; Q6NX49: ZNF544; NbExp=3; IntAct=EBI-744794, EBI-2841978;
CC Q9BZW7; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-744794, EBI-6427977;
CC Q9BZW7; Q96NL3: ZNF599; NbExp=3; IntAct=EBI-744794, EBI-8653994;
CC Q9BZW7; Q9BS34: ZNF670; NbExp=3; IntAct=EBI-744794, EBI-745276;
CC Q9BZW7; A0A1U9X8X8; NbExp=3; IntAct=EBI-744794, EBI-17234977;
CC Q9BZW7; Q9H6F0; NbExp=3; IntAct=EBI-744794, EBI-10307481;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Z220}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome,
CC centriole {ECO:0000269|PubMed:28905369}. Note=In mature spermatozoa,
CC localizes to the centriole and midpiece (PubMed:28905369). The 27-kDa
CC peptide associates with the fibrous sheath in mature spermatozoa and
CC localizes to the principal piece of sperm tail, while the 55-kDa
CC peptide localizes to the midpiece (By similarity). Detected in the
CC cytoplasm of almost all spermatogonial cells within the seminiferous
CC tubules (By similarity). {ECO:0000250|UniProtKB:Q9Z220,
CC ECO:0000269|PubMed:28905369}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9BZW7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BZW7-2; Sequence=VSP_054409, VSP_054410;
CC -!- TISSUE SPECIFICITY: Expressed in the testis, in spermatozoa (at protein
CC level) (PubMed:11179690, PubMed:28905369). Expressed in actively
CC dividing fetal tissues, including sternum, intestine, limb, kidney and
CC stomach (PubMed:14585816). {ECO:0000269|PubMed:11179690,
CC ECO:0000269|PubMed:14585816, ECO:0000269|PubMed:28905369}.
CC -!- PTM: Processed into N-terminal 27-kDa and C-terminal 55-kDa fragments.
CC {ECO:0000250|UniProtKB:Q6NY15}.
CC -!- DISEASE: Spermatogenic failure 26 (SPGF26) [MIM:617961]: An autosomal
CC recessive infertility disorder caused by spermatogenesis defects that
CC result in acephalic spermatozoa. {ECO:0000269|PubMed:28905369}.
CC Note=The disease is caused by variants affecting the gene represented
CC in this entry.
CC -!- SIMILARITY: Belongs to the CEP135/TSGA10 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF254756; AAK13079.1; -; mRNA.
DR EMBL; AY014284; AAK27309.1; -; mRNA.
DR EMBL; AK304328; BAH14161.1; -; mRNA.
DR EMBL; AC019097; AAY14820.1; -; Genomic_DNA.
DR EMBL; AC092587; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC110083; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471127; EAX01889.1; -; Genomic_DNA.
DR EMBL; CH471127; EAX01890.1; -; Genomic_DNA.
DR EMBL; CH471127; EAX01891.1; -; Genomic_DNA.
DR EMBL; CH471127; EAX01892.1; -; Genomic_DNA.
DR EMBL; BC028366; AAH28366.1; -; mRNA.
DR CCDS; CCDS2037.1; -. [Q9BZW7-1]
DR RefSeq; NP_079520.1; NM_025244.2. [Q9BZW7-1]
DR RefSeq; NP_878915.2; NM_182911.3. [Q9BZW7-1]
DR RefSeq; XP_005264080.1; XM_005264023.1. [Q9BZW7-1]
DR RefSeq; XP_005264081.1; XM_005264024.2. [Q9BZW7-1]
DR RefSeq; XP_005264082.1; XM_005264025.1. [Q9BZW7-1]
DR RefSeq; XP_005264083.1; XM_005264026.1. [Q9BZW7-1]
DR RefSeq; XP_005264084.1; XM_005264027.1. [Q9BZW7-1]
DR RefSeq; XP_005264086.1; XM_005264029.1. [Q9BZW7-1]
DR RefSeq; XP_006712844.1; XM_006712781.2. [Q9BZW7-1]
DR RefSeq; XP_011510239.1; XM_011511937.1. [Q9BZW7-1]
DR RefSeq; XP_011510241.1; XM_011511939.1. [Q9BZW7-1]
DR RefSeq; XP_011510242.1; XM_011511940.2.
DR RefSeq; XP_011510243.1; XM_011511941.1. [Q9BZW7-1]
DR RefSeq; XP_011510244.1; XM_011511942.1. [Q9BZW7-1]
DR RefSeq; XP_011510245.1; XM_011511943.2.
DR RefSeq; XP_016860528.1; XM_017005039.1. [Q9BZW7-1]
DR RefSeq; XP_016860529.1; XM_017005040.1. [Q9BZW7-1]
DR RefSeq; XP_016860530.1; XM_017005041.1. [Q9BZW7-1]
DR RefSeq; XP_016860531.1; XM_017005042.1. [Q9BZW7-1]
DR RefSeq; XP_016860532.1; XM_017005043.1. [Q9BZW7-1]
DR RefSeq; XP_016860533.1; XM_017005044.1. [Q9BZW7-1]
DR RefSeq; XP_016860534.1; XM_017005045.1. [Q9BZW7-1]
DR RefSeq; XP_016860535.1; XM_017005046.1. [Q9BZW7-1]
DR RefSeq; XP_016860536.1; XM_017005047.1. [Q9BZW7-1]
DR RefSeq; XP_016860537.1; XM_017005048.1. [Q9BZW7-1]
DR AlphaFoldDB; Q9BZW7; -.
DR SMR; Q9BZW7; -.
DR BioGRID; 123267; 92.
DR IntAct; Q9BZW7; 81.
DR MINT; Q9BZW7; -.
DR STRING; 9606.ENSP00000377123; -.
DR GlyGen; Q9BZW7; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9BZW7; -.
DR PhosphoSitePlus; Q9BZW7; -.
DR BioMuta; TSGA10; -.
DR DMDM; 74724919; -.
DR EPD; Q9BZW7; -.
DR jPOST; Q9BZW7; -.
DR MassIVE; Q9BZW7; -.
DR PaxDb; Q9BZW7; -.
DR PeptideAtlas; Q9BZW7; -.
DR PRIDE; Q9BZW7; -.
DR ProteomicsDB; 6998; -.
DR ProteomicsDB; 79912; -. [Q9BZW7-1]
DR Antibodypedia; 32767; 141 antibodies from 20 providers.
DR DNASU; 80705; -.
DR Ensembl; ENST00000355053.8; ENSP00000347161.4; ENSG00000135951.16. [Q9BZW7-1]
DR Ensembl; ENST00000393483.8; ENSP00000377123.3; ENSG00000135951.16. [Q9BZW7-1]
DR Ensembl; ENST00000410001.5; ENSP00000386956.1; ENSG00000135951.16. [Q9BZW7-1]
DR GeneID; 80705; -.
DR KEGG; hsa:80705; -.
DR MANE-Select; ENST00000393483.8; ENSP00000377123.3; NM_025244.4; NP_079520.1.
DR UCSC; uc002szg.5; human. [Q9BZW7-1]
DR CTD; 80705; -.
DR DisGeNET; 80705; -.
DR GeneCards; TSGA10; -.
DR HGNC; HGNC:14927; TSGA10.
DR HPA; ENSG00000135951; Tissue enriched (testis).
DR MalaCards; TSGA10; -.
DR MIM; 607166; gene.
DR MIM; 617961; phenotype.
DR neXtProt; NX_Q9BZW7; -.
DR OpenTargets; ENSG00000135951; -.
DR PharmGKB; PA37933; -.
DR VEuPathDB; HostDB:ENSG00000135951; -.
DR eggNOG; ENOG502RJHC; Eukaryota.
DR GeneTree; ENSGT00940000159205; -.
DR InParanoid; Q9BZW7; -.
DR OrthoDB; 139407at2759; -.
DR PhylomeDB; Q9BZW7; -.
DR TreeFam; TF326518; -.
DR PathwayCommons; Q9BZW7; -.
DR SignaLink; Q9BZW7; -.
DR BioGRID-ORCS; 80705; 9 hits in 1073 CRISPR screens.
DR ChiTaRS; TSGA10; human.
DR GenomeRNAi; 80705; -.
DR Pharos; Q9BZW7; Tbio.
DR PRO; PR:Q9BZW7; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q9BZW7; protein.
DR Bgee; ENSG00000135951; Expressed in sperm and 113 other tissues.
DR ExpressionAtlas; Q9BZW7; baseline and differential.
DR Genevisible; Q9BZW7; HS.
DR GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0031514; C:motile cilium; IBA:GO_Central.
DR GO; GO:0007283; P:spermatogenesis; TAS:UniProtKB.
DR InterPro; IPR033323; TSGA10.
DR PANTHER; PTHR23159:SF14; PTHR23159:SF14; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Cytoskeleton; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..698
FT /note="Testis-specific gene 10 protein"
FT /id="PRO_0000307125"
FT REGION 556..689
FT /note="Interaction with HIF1A"
FT /evidence="ECO:0000250"
FT REGION 659..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..685
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 163
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 688
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Z220"
FT VAR_SEQ 295..297
FT /note="EKT -> TVY (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_054409"
FT VAR_SEQ 298..698
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_054410"
FT CONFLICT 28
FT /note="T -> EP (in Ref. 2; AAK27309)"
FT /evidence="ECO:0000305"
FT CONFLICT 273
FT /note="L -> M (in Ref. 6; AAH28366)"
FT /evidence="ECO:0000305"
FT CONFLICT 365
FT /note="K -> N (in Ref. 2; AAK27309)"
FT /evidence="ECO:0000305"
FT CONFLICT 624
FT /note="E -> G (in Ref. 2; AAK27309)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 698 AA; 81421 MW; 8338D7FAAA2F2473 CRC64;
MMRSRSKSPR RPSPTARGAN CDVELLKTTT RDREELKCML EKYERHLAEI QGNVKVLKSE
RDKIFLLYEQ AQEEITRLRR EMMKSCKSPK STTAHAILRR VETERDVAFT DLRRMTTERD
SLRERLKIAQ ETAFNEKAHL EQRIEELECT VHNLDDERME QMSNMTLMKE TISTVEKEMK
SLARKAMDTE SELGRQKAEN NSLRLLYENT EKDLSDTQRH LAKKKYELQL TQEKIMCLDE
KIDNFTRQNI AQREEISILG GTLNDLAKEK ECLQACLDKK SENIASLGES LAMKEKTISG
MKNIIAEMEQ ASRQCTEALI VCEQDVSRMR RQLDETNDEL AQIARERDIL AHDNDNLQEQ
FAKAKQENQA LSKKLNDTHN ELNDIKQKVQ DTNLEVNKLK NILKSEESEN RQMMEQLRKA
NEDAENWENK ARQSEADNNT LKLELITAEA EGNRLKEKVD SLNREVEQHL NAERSYKSQI
STLHKSVVKM EEELQKVQFE KVSALADLSS TRELCIKLDS SKELLNRQLV AKDQEIEMRE
NELDSAHSEI ELLRSQMANE RISMQNLEAL LVANRDKEYQ SQIALQEKES EIQLLKEHLC
LAENKMAIQS RDVAQFRNVV TQLEADLDIT KRQLGTERFE RERAVQELRR QNYSSNAYHM
SSTMKPNTKC HSPERAHHRS PDRGLDRSLE ENLCYRDF
