ID   TSG10_MACFA             Reviewed;         601 AA.
AC   Q4R6W3;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Testis-specific gene 10 protein;
GN   Name=TSGA10; ORFNames=QtsA-17006;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in spermatogenesis (By similarity). When
CC       overexpressed, prevents nuclear localization of HIF1A (By similarity).
CC       {ECO:0000250|UniProtKB:Q6NY15, ECO:0000250|UniProtKB:Q9BZW7}.
CC   -!- SUBUNIT: Interacts with HIF1A. {ECO:0000250|UniProtKB:Q6NY15}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Z220}.
CC       Cytoplasm, cytoskeleton, microtubule organizing center, centrosome,
CC       centriole {ECO:0000250|UniProtKB:Q9BZW7}. Note=In mature spermatozoa,
CC       localizes to the centriole and midpiece (By similarity). The 27-kDa
CC       peptide associates with the fibrous sheath in mature spermatozoa and
CC       localizes to the principal piece of sperm tail, while the 55-kDa
CC       peptide localizes to the midpiece. Detected in the cytoplasm of almost
CC       all spermatogonial cells within the seminiferous tubules (By
CC       similarity). {ECO:0000250|UniProtKB:Q9BZW7,
CC       ECO:0000250|UniProtKB:Q9Z220}.
CC   -!- PTM: Processed into N-terminal 27-kDa and C-terminal 55-kDa fragments.
CC       {ECO:0000250|UniProtKB:Q6NY15}.
CC   -!- SIMILARITY: Belongs to the CEP135/TSGA10 family. {ECO:0000305}.
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DR   EMBL; AB169067; BAE01161.1; -; mRNA.
DR   AlphaFoldDB; Q4R6W3; -.
DR   SMR; Q4R6W3; -.
DR   PRIDE; Q4R6W3; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0007283; P:spermatogenesis; IEA:InterPro.
DR   InterPro; IPR033323; TSGA10.
DR   PANTHER; PTHR23159:SF14; PTHR23159:SF14; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome.
FT   CHAIN           1..601
FT                   /note="Testis-specific gene 10 protein"
FT                   /id="PRO_0000307126"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          459..592
FT                   /note="Interaction with HIF1A"
FT                   /evidence="ECO:0000250"
FT   REGION          563..588
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        573..588
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         591
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Z220"
SQ   SEQUENCE   601 AA;  69906 MW;  D38923AD20071224 CRC64;
     MMRSRSKSPR RPSPTARGAN CDVELLKTTT RDREELKCML EKYERHLAEI QGNVKVLTSE
     RDKTFLLYEQ AQEEIARLRR EMKSLARKAM DTESELGRQK AENNSLRLLY ENTEKDLSDT
     QRHLAKKKYE LQLTQEKIMC LDEKIDNFTR QNIAQREEIS ILGGTLNDLA KEKECLQACL
     DKKSENIASL GESLAMKEKT ISGMKNIIAE MEQASRQSTE ALIMCEQDIS RMRRQLDETN
     DELAQIARER DILAHDNDNL QEQFAKAKQE NQALSKKLND THNELNDIKQ KVQDTNLEVN
     KLKNILKSEE SENRQMMEQL RKANEDAENW ENKARQSEAD NNTLKLELIT AEAEGNRLKE
     KVDSLSREVE QHLNAERSYK SQISTLHKSV VKMEEELQKV QFEKVSALAD LSSTRELCIK
     LDSSKELLNR QLVAKDQEIE MMENELDSAR SEIELLRSQM TNERISMQNL EALLVANRDK
     EYQSQIALQE KESEIQLLKE HLCLAENKMA IQSRDVAQFR NVVTQLEADL DITKRQLGTE
     RFERERAVQE LRRQNYSSNA YHVSSTMKPN TKCHSPERAH HRSPDRGLDR SLEENLCYRD
     F