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TSG13_HUMAN
ID   TSG13_HUMAN             Reviewed;         275 AA.
AC   Q96PP4; B3KSC9;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Testis-specific gene 13 protein;
GN   Name=TSGA13;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Blagitko-Dorfs N., Fischer U., Ropers H.-H., Kalscheuer V.M.;
RT   "Identification of a testis-specific gene that maps telomeric to the MEST-
RT   COPG2 imprinting cluster on human chromosome 7q32.";
RL   Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Guo J.H., Yu L.;
RL   Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12690205; DOI=10.1126/science.1083423;
RA   Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA   Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA   Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA   Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA   Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA   Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA   Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA   Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA   Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA   Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA   Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA   Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA   Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA   Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA   Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA   Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA   Adams M.D., Tsui L.-C.;
RT   "Human chromosome 7: DNA sequence and biology.";
RL   Science 300:767-772(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q96PP4; P40692: MLH1; NbExp=3; IntAct=EBI-12390276, EBI-744248;
CC   -!- TISSUE SPECIFICITY: Testis-specific.
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DR   EMBL; AF294347; AAK97089.1; -; mRNA.
DR   EMBL; AF431815; AAP97305.1; -; mRNA.
DR   EMBL; AK093329; BAG52691.1; -; mRNA.
DR   EMBL; CH236950; EAL24084.1; -; Genomic_DNA.
DR   EMBL; CH471070; EAW83771.1; -; Genomic_DNA.
DR   EMBL; BC038415; AAH38415.1; -; mRNA.
DR   CCDS; CCDS5824.1; -.
DR   RefSeq; NP_001291897.1; NM_001304968.1.
DR   RefSeq; NP_443165.1; NM_052933.3.
DR   AlphaFoldDB; Q96PP4; -.
DR   BioGRID; 125401; 4.
DR   IntAct; Q96PP4; 3.
DR   STRING; 9606.ENSP00000406047; -.
DR   iPTMnet; Q96PP4; -.
DR   PhosphoSitePlus; Q96PP4; -.
DR   BioMuta; TSGA13; -.
DR   DMDM; 74732656; -.
DR   MassIVE; Q96PP4; -.
DR   PaxDb; Q96PP4; -.
DR   PeptideAtlas; Q96PP4; -.
DR   PRIDE; Q96PP4; -.
DR   ProteomicsDB; 77724; -.
DR   Antibodypedia; 46068; 105 antibodies from 19 providers.
DR   DNASU; 114960; -.
DR   Ensembl; ENST00000356588.8; ENSP00000348996.3; ENSG00000213265.9.
DR   Ensembl; ENST00000456951.5; ENSP00000406047.1; ENSG00000213265.9.
DR   GeneID; 114960; -.
DR   KEGG; hsa:114960; -.
DR   MANE-Select; ENST00000356588.8; ENSP00000348996.3; NM_052933.4; NP_443165.1.
DR   UCSC; uc003vqi.4; human.
DR   CTD; 114960; -.
DR   DisGeNET; 114960; -.
DR   GeneCards; TSGA13; -.
DR   HGNC; HGNC:12369; TSGA13.
DR   HPA; ENSG00000213265; Tissue enriched (testis).
DR   neXtProt; NX_Q96PP4; -.
DR   OpenTargets; ENSG00000213265; -.
DR   PharmGKB; PA37038; -.
DR   VEuPathDB; HostDB:ENSG00000213265; -.
DR   eggNOG; ENOG502S9MD; Eukaryota.
DR   GeneTree; ENSGT00390000009822; -.
DR   HOGENOM; CLU_088610_0_0_1; -.
DR   InParanoid; Q96PP4; -.
DR   OMA; QWIIKNA; -.
DR   OrthoDB; 1202249at2759; -.
DR   PhylomeDB; Q96PP4; -.
DR   TreeFam; TF328772; -.
DR   PathwayCommons; Q96PP4; -.
DR   SignaLink; Q96PP4; -.
DR   BioGRID-ORCS; 114960; 12 hits in 1069 CRISPR screens.
DR   GenomeRNAi; 114960; -.
DR   Pharos; Q96PP4; Tdark.
DR   PRO; PR:Q96PP4; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; Q96PP4; protein.
DR   Bgee; ENSG00000213265; Expressed in left testis and 18 other tissues.
DR   ExpressionAtlas; Q96PP4; baseline and differential.
DR   Genevisible; Q96PP4; HS.
DR   InterPro; IPR029241; TSGA13.
DR   PANTHER; PTHR37352; PTHR37352; 1.
DR   Pfam; PF14994; TSGA13; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..275
FT                   /note="Testis-specific gene 13 protein"
FT                   /id="PRO_0000286344"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   275 AA;  31778 MW;  FFF094BEAD6DA158 CRC64;
     MSQKRQTKFQ NGKSKTSENS SAKREKGMVV NSKEISDAVG QSKFVLENLR HYTVHPNLAQ
     YYKPLKATAL QKFLAQNRKN TSFMLKVTQY DQDKTLLIMT NNPPPCSITQ QDKESASKYF
     SKELLLKVME SHHQHKPTEN LWLPRMPQKK KLRSKLKPIF PLILSDDPTS KREQWFRFST
     DNDFKSEGKY SKVYALRTQK KMYPQLTFAP VHERDMRKDA SKKSASERPI SKVIREPLTL
     ASLLEDMPTR TAPGESAFRN GRAPQWIIKK ATVIG
 
 
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