ID   TSGA_BUCAI              Reviewed;         388 AA.
AC   P57601;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Protein TsgA homolog {ECO:0000255|HAMAP-Rule:MF_01044};
GN   Name=tsgA {ECO:0000255|HAMAP-Rule:MF_01044}; OrderedLocusNames=BU535;
OS   Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon
OS   pisum symbiotic bacterium).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=107806;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=APS;
RX   PubMed=10993077; DOI=10.1038/35024074;
RA   Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.;
RT   "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera
RT   sp. APS.";
RL   Nature 407:81-86(2000).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01044};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01044}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. TsgA family.
CC       {ECO:0000255|HAMAP-Rule:MF_01044}.
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DR   EMBL; BA000003; BAB13228.1; -; Genomic_DNA.
DR   RefSeq; NP_240342.1; NC_002528.1.
DR   RefSeq; WP_009874486.1; NC_002528.1.
DR   AlphaFoldDB; P57601; -.
DR   SMR; P57601; -.
DR   STRING; 107806.10039194; -.
DR   EnsemblBacteria; BAB13228; BAB13228; BAB13228.
DR   KEGG; buc:BU535; -.
DR   PATRIC; fig|107806.10.peg.540; -.
DR   eggNOG; COG0738; Bacteria.
DR   HOGENOM; CLU_056916_0_0_6; -.
DR   OMA; RFGFVLM; -.
DR   Proteomes; UP000001806; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   HAMAP; MF_01044; MFS_TsgA; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR023528; MFS_TsgA.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..388
FT                   /note="Protein TsgA homolog"
FT                   /id="PRO_0000206491"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01044"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01044"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01044"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01044"
FT   TRANSMEM        133..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01044"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01044"
FT   TRANSMEM        206..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01044"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01044"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01044"
FT   TRANSMEM        298..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01044"
FT   TRANSMEM        332..352
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01044"
FT   TRANSMEM        360..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01044"
SQ   SEQUENCE   388 AA;  44301 MW;  E9DFC3A520365043 CRC64;
     MTNINRIGLT WISFLSYAFT GALVVVTGMI MGNISNYFHL SISQMSNIFT FLNAGILVSI
     FINSWLIEII SLKKQLIFSF ILTIIAVIGI VLCNSIFLFS INMFILGLVS GITMSIGTFI
     ITHLYSGSKR GSLLLLTDSF FSMSGMIFPI VTAYLLEKKI IWYWSYICIG AIYLLIFLLT
     INSSFEKFKT NTKNSKETKE KWNFNVFLLS ISALLYILGQ LGFISWVPQY ATEIMNIDIK
     KTGSLVSGFW MSYMLGMWFF SFIIKFFNLY RMFIFLTSMS TILMYCFIKS ENFLNQQYII
     ISLGFFSSAI YTIIITLASL QTKHPSPKLI NLILLFGTIG TFLTFIITSP IVEAKGLYVT
     LISSNILYGI VFFLSILIYF NKKYERVI