TSGA_ECOL6
ID TSGA_ECOL6 Reviewed; 393 AA.
AC P60779; P21229; P37612;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 13-APR-2004, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Protein TsgA;
GN Name=tsgA; OrderedLocusNames=c4139;
OS Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=199310;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFT073 / ATCC 700928 / UPEC;
RX PubMed=12471157; DOI=10.1073/pnas.252529799;
RA Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA Donnenberg M.S., Blattner F.R.;
RT "Extensive mosaic structure revealed by the complete genome sequence of
RT uropathogenic Escherichia coli.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. TsgA family.
CC {ECO:0000305}.
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DR EMBL; AE014075; AAN82577.1; -; Genomic_DNA.
DR RefSeq; WP_000185247.1; NC_004431.1.
DR AlphaFoldDB; P60779; -.
DR SMR; P60779; -.
DR STRING; 199310.c4139; -.
DR EnsemblBacteria; AAN82577; AAN82577; c4139.
DR GeneID; 66672755; -.
DR KEGG; ecc:c4139; -.
DR eggNOG; COG0738; Bacteria.
DR HOGENOM; CLU_056916_0_0_6; -.
DR OMA; RFGFVLM; -.
DR BioCyc; ECOL199310:C4139-MON; -.
DR Proteomes; UP000001410; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 2.
DR HAMAP; MF_01044; MFS_TsgA; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR023528; MFS_TsgA.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..393
FT /note="Protein TsgA"
FT /id="PRO_0000206495"
FT TOPO_DOM 1..10
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 32..50
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72..77
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 99..100
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..133
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 155..161
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 183..205
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227..244
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..272
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..296
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 318..331
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 332..352
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 353..360
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 382..393
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 393 AA; 43166 MW; 75445C6136809691 CRC64;
MTNSNRIKLT WISFLSYALT GALVIVTGMV MGNIADYFNL PVSSMSNTFT FLNAGILISI
FLNAWLMEIV PLKTQLRFGF LLMVLAVAGL MFSHSLALFS AAMFILGVVS GITMSIGTFL
VTQMYEGRQR GSRLLFTDSF FSMAGMIFPM IAAFLLARSI EWYWVYACIG LVYVAIFILT
FGCEFPALGK HAPKTDAPVE KEKWGIGVLF LSVAALCYIL GQLGFISWVP EYAKGLGMSL
NDAGTLVSNF WMSYMVGMWA FSFILRFFDL QRILTVLAGL AAILMYVFNT GTPAHMAWSI
LALGFFSSAI YTTIITLGSQ QTKVPSPKLV NFVLTCGTIG TMLTFVVTGP IVEHSGPQAA
LLTANGLYAV VFVMCFLLGF VSRHRQHNTL TSH
