TSGA_SALTY
ID TSGA_SALTY Reviewed; 393 AA.
AC Q8ZLK7;
DT 01-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Protein TsgA;
GN Name=tsgA; OrderedLocusNames=STM3473;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. TsgA family.
CC {ECO:0000305}.
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DR EMBL; AE006468; AAL22335.1; -; Genomic_DNA.
DR RefSeq; NP_462376.1; NC_003197.2.
DR RefSeq; WP_000185211.1; NC_003197.2.
DR AlphaFoldDB; Q8ZLK7; -.
DR SMR; Q8ZLK7; -.
DR STRING; 99287.STM3473; -.
DR PaxDb; Q8ZLK7; -.
DR EnsemblBacteria; AAL22335; AAL22335; STM3473.
DR GeneID; 1254996; -.
DR KEGG; stm:STM3473; -.
DR PATRIC; fig|99287.12.peg.3670; -.
DR HOGENOM; CLU_056916_0_0_6; -.
DR OMA; RFGFVLM; -.
DR PhylomeDB; Q8ZLK7; -.
DR BioCyc; SENT99287:STM3473-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 2.
DR HAMAP; MF_01044; MFS_TsgA; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR023528; MFS_TsgA.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..393
FT /note="Protein TsgA"
FT /id="PRO_0000206500"
FT TOPO_DOM 1..10
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 32..50
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72..77
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 99..100
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..133
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 155..161
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 183..205
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227..244
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..272
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..297
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..318
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 319..331
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 332..352
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 353..360
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 382..393
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 393 AA; 43130 MW; 3BAA33986B7F2E34 CRC64;
MTNSNRIKLT WISFLSYALT GALVIVTGMV MGNIADYFHL PVSSMSNTFT FLNAGILISI
FLNAWLMEII PLKTQLRFGF ILMVLAVAGL MFGHSLALFS AAMFVLGLVS GITMSIGTFL
ITQLYEGRQR GSRLLFTDSF FSMAGMIFPM VAAFLLARSI EWYWVYACIG LVYLAIFILT
FGCEFPALGK HAQHSQAPVV KEKWGIGVLF LAVAALCYIL GQLGFISWVP EYAKGLGMSL
NDAGALVSDF WMSYMFGMWA FSFILRFFDL QRILTVLAGM AAVLMYLFIT GTQAHMPWFI
LTLGFFSSAI YTSIITLGSQ QTKVASPKLV NFILTCGTIG TMLTFVVTGP IVAHSGPQAA
LLTANGLYAV VFVMCFALGF VSRHRQHSAP ATH
