C3H63_ARATH
ID C3H63_ARATH Reviewed; 443 AA.
AC Q9FNZ1; Q9FJ94;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Zinc finger CCCH domain-containing protein 63;
DE Short=AtC3H63;
DE AltName: Full=Zinc finger CCCH domain and WD40 repeat-containing protein 2;
GN Name=ZFWD2; OrderedLocusNames=At5g51980; ORFNames=MSG15.6;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=11137290; DOI=10.1016/s0378-1119(00)00446-7;
RA Terol J., Bargues M., Perez-Alonso M.;
RT "ZFWD: a novel subfamily of plant proteins containing a C3H zinc finger and
RT seven WD40 repeats.";
RL Gene 260:45-53(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9872454; DOI=10.1093/dnares/5.5.297;
RA Nakamura Y., Sato S., Asamizu E., Kaneko T., Kotani H., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VII. Sequence
RT features of the regions of 1,013,767 bp covered by sixteen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:297-308(1998).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=14993207; DOI=10.1101/gr.1515604;
RA Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA Weissenbach J., Salanoubat M.;
RT "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT combined approach to evaluate and improve Arabidopsis genome annotation.";
RL Genome Res. 14:406-413(2004).
RN [5]
RP NOMENCLATURE.
RX PubMed=18221561; DOI=10.1186/1471-2164-9-44;
RA Wang D., Guo Y., Wu C., Yang G., Li Y., Zheng C.;
RT "Genome-wide analysis of CCCH zinc finger family in Arabidopsis and rice.";
RL BMC Genomics 9:44-44(2008).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9FNZ1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9FNZ1-2; Sequence=VSP_037130;
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice
CC site. {ECO:0000305}.
CC -!- SEQUENCE CAUTION: [Isoform 2]:
CC Sequence=BX831861; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AJ252064; CAC19848.1; -; mRNA.
DR EMBL; AB015478; BAB11046.1; -; Genomic_DNA.
DR EMBL; CP002688; AED96154.1; -; Genomic_DNA.
DR EMBL; CP002688; AED96155.2; -; Genomic_DNA.
DR EMBL; BX831861; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_001318784.1; NM_001344972.1. [Q9FNZ1-2]
DR RefSeq; NP_200011.1; NM_124577.4. [Q9FNZ1-2]
DR AlphaFoldDB; Q9FNZ1; -.
DR SMR; Q9FNZ1; -.
DR BioGRID; 20518; 7.
DR IntAct; Q9FNZ1; 7.
DR STRING; 3702.AT5G51980.2; -.
DR PaxDb; Q9FNZ1; -.
DR PeptideAtlas; Q9FNZ1; -.
DR PRIDE; Q9FNZ1; -.
DR ProteomicsDB; 240385; -. [Q9FNZ1-1]
DR EnsemblPlants; AT5G51980.1; AT5G51980.1; AT5G51980. [Q9FNZ1-2]
DR EnsemblPlants; AT5G51980.2; AT5G51980.2; AT5G51980. [Q9FNZ1-2]
DR GeneID; 835273; -.
DR Gramene; AT5G51980.1; AT5G51980.1; AT5G51980. [Q9FNZ1-2]
DR Gramene; AT5G51980.2; AT5G51980.2; AT5G51980. [Q9FNZ1-2]
DR KEGG; ath:AT5G51980; -.
DR Araport; AT5G51980; -.
DR TAIR; locus:2173103; AT5G51980.
DR eggNOG; KOG0274; Eukaryota.
DR InParanoid; Q9FNZ1; -.
DR OMA; DGNCTYG; -.
DR OrthoDB; 757685at2759; -.
DR PhylomeDB; Q9FNZ1; -.
DR PRO; PR:Q9FNZ1; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FNZ1; baseline and differential.
DR Genevisible; Q9FNZ1; AT.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003729; F:mRNA binding; IDA:TAIR.
DR GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR044715; WDR86-like.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR036855; Znf_CCCH_sf.
DR PANTHER; PTHR44489; PTHR44489; 1.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SMART; SM00356; ZnF_C3H1; 2.
DR SUPFAM; SSF50978; SSF50978; 1.
DR SUPFAM; SSF90229; SSF90229; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
DR PROSITE; PS50103; ZF_C3H1; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Reference proteome;
KW Repeat; WD repeat; Zinc; Zinc-finger.
FT CHAIN 1..443
FT /note="Zinc finger CCCH domain-containing protein 63"
FT /id="PRO_0000372013"
FT REPEAT 149..190
FT /note="WD 1"
FT REPEAT 228..265
FT /note="WD 2"
FT REPEAT 272..311
FT /note="WD 3"
FT REPEAT 313..349
FT /note="WD 4"
FT REPEAT 354..396
FT /note="WD 5"
FT REPEAT 404..442
FT /note="WD 6"
FT ZN_FING 30..56
FT /note="C3H1-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 109..136
FT /note="C3H1-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 56..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 391..396
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14993207"
FT /id="VSP_037130"
SQ SEQUENCE 443 AA; 47987 MW; 17F9C80E8851982C CRC64;
MDFDLNGGNK RVFNRLGGGG GSTRPMAPTD TRQKVCFHWR AGRCNRSPCP YLHRELPGPG
PGQGQGPGYT NKRVAEESGF AGPSHRRGPG FNGNSSSSWG RFGGNRTVTK TEKVCNFWVD
GNCTYGDKCR YLHCWSKGES FALLTQLDGH EKLVSGIALP SGSDKLYTGS KDETLRVWDC
ASGQCTGVLK LGGEIGCVLS EGPWLLVGMP NLVKAWNIET NADQSLSGPV GQVYSLVVGT
DLLFAGTQDG SILAWRYNAA TNCFEPSASL TGHTLAVVTL YVGANRLYSG SMDKTIKVWS
LDNLQCIQTL TDHSSVVMSL ICWDQFLLSC SLDNTVKIWA AIEGGNLEVT YTHKEEHGVL
ALCGVHDAEA KPVLLCACND NTLRLYDLPS LGLFIRFTER GKIFAKQEIR AIQIGPGGIF
FTGDGTGQVK VWKWCTEPTA ALP
