TSGA_YERPE
ID TSGA_YERPE Reviewed; 394 AA.
AC Q8ZJE6; Q0WKD9;
DT 01-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 119.
DE RecName: Full=Protein TsgA homolog {ECO:0000255|HAMAP-Rule:MF_01044};
GN Name=tsgA {ECO:0000255|HAMAP-Rule:MF_01044}; Synonyms=proP2;
GN OrderedLocusNames=YPO0163, y3947, YP_0165;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01044}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01044}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. TsgA family.
CC {ECO:0000255|HAMAP-Rule:MF_01044}.
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DR EMBL; AL590842; CAL18849.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM87491.1; -; Genomic_DNA.
DR EMBL; AE017042; AAS60443.1; -; Genomic_DNA.
DR PIR; AH0020; AH0020.
DR RefSeq; WP_002215690.1; NZ_WUCM01000004.1.
DR RefSeq; YP_002345249.1; NC_003143.1.
DR AlphaFoldDB; Q8ZJE6; -.
DR SMR; Q8ZJE6; -.
DR STRING; 214092.YPO0163; -.
DR PaxDb; Q8ZJE6; -.
DR DNASU; 1148894; -.
DR EnsemblBacteria; AAM87491; AAM87491; y3947.
DR EnsemblBacteria; AAS60443; AAS60443; YP_0165.
DR GeneID; 57974438; -.
DR KEGG; ype:YPO0163; -.
DR KEGG; ypk:y3947; -.
DR KEGG; ypm:YP_0165; -.
DR PATRIC; fig|214092.21.peg.393; -.
DR eggNOG; COG0738; Bacteria.
DR HOGENOM; CLU_056916_0_0_6; -.
DR OMA; RFGFVLM; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 2.
DR HAMAP; MF_01044; MFS_TsgA; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR023528; MFS_TsgA.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..394
FT /note="Protein TsgA homolog"
FT /id="PRO_0000206502"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01044"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01044"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01044"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01044"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01044"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01044"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01044"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01044"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01044"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01044"
FT TRANSMEM 334..354
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01044"
FT TRANSMEM 363..383
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01044"
SQ SEQUENCE 394 AA; 43653 MW; 9FDE20F20295E92A CRC64;
MNNSNRIRLT WISYLSYALT GALVIVTGIV MGNIAEYFNL PIASMSNTFT FLNAGILISI
FLNAWLMEII PLKRQLVFGF ILMLIAIAGL MVGHNLMIFS ISMFIFGVVS GITMSIGTFL
VTHMYEGRQR GSRLLFTDSF FSMAGMIFPI AAAMLLARHI EWYWVYACIG LLYVGIFVLT
LCSEFPVLGH KATDQSKPVV KEKWGVGVLF LAIAALCYIL GQLGFIQWVP EYATKTFNMN
ISQAGQLVSN FWISYMIGMW IFSFILRFFD LQRIVTVLAA MATLAMYLFV STDNPAYLSY
YILALGFVSS AIYTTLITLG SLQTKVSSPK LVNFILTCGT VGTMLTFVVT GPIVANNGVH
AALETANGLY LAVFILCLAL GFFTKHRSHG HVTH
