ID   TSHB_CHICK              Reviewed;         134 AA.
AC   O57340;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Thyrotropin subunit beta;
DE   AltName: Full=Thyroid-stimulating hormone subunit beta;
DE            Short=TSH-B;
DE            Short=TSH-beta;
DE   AltName: Full=Thyrotropin beta chain;
DE   Flags: Precursor;
GN   Name=TSHB;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary anterior lobe;
RX   PubMed=9245526; DOI=10.1006/gcen.1997.6911;
RA   Gregory C.C., Porter T.E.;
RT   "Cloning and sequence analysis of a cDNA for the beta subunit of chicken
RT   thyroid-stimulating hormone.";
RL   Gen. Comp. Endocrinol. 107:182-190(1997).
CC   -!- FUNCTION: Indispensable for the control of thyroid structure and
CC       metabolism. {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of a common alpha chain and a unique beta chain
CC       which confers biological specificity to thyrotropin, lutropin,
CC       follitropin and gonadotropin.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC       {ECO:0000305}.
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DR   EMBL; AF033495; AAB88127.1; -; mRNA.
DR   RefSeq; NP_990394.1; NM_205063.2.
DR   RefSeq; XP_015154381.1; XM_015298895.1.
DR   RefSeq; XP_015154382.1; XM_015298896.1.
DR   AlphaFoldDB; O57340; -.
DR   SMR; O57340; -.
DR   STRING; 9031.ENSGALP00000004015; -.
DR   PaxDb; O57340; -.
DR   Ensembl; ENSGALT00000004024; ENSGALP00000004015; ENSGALG00000002550.
DR   GeneID; 395937; -.
DR   KEGG; gga:395937; -.
DR   CTD; 7252; -.
DR   VEuPathDB; HostDB:geneid_395937; -.
DR   eggNOG; ENOG502S2JW; Eukaryota.
DR   GeneTree; ENSGT00940000158152; -.
DR   HOGENOM; CLU_126319_0_2_1; -.
DR   InParanoid; O57340; -.
DR   OMA; PTEYMMH; -.
DR   OrthoDB; 1362225at2759; -.
DR   PhylomeDB; O57340; -.
DR   TreeFam; TF332940; -.
DR   Reactome; R-GGA-209822; Glycoprotein hormones.
DR   Reactome; R-GGA-209968; Thyroxine biosynthesis.
DR   Reactome; R-GGA-375281; Hormone ligand-binding receptors.
DR   Reactome; R-GGA-418555; G alpha (s) signalling events.
DR   PRO; PR:O57340; -.
DR   Proteomes; UP000000539; Chromosome 26.
DR   Bgee; ENSGALG00000002550; Expressed in spleen and 8 other tissues.
DR   ExpressionAtlas; O57340; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   CDD; cd00069; GHB_like; 1.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006208; Glyco_hormone_CN.
DR   InterPro; IPR001545; Gonadotropin_bsu.
DR   InterPro; IPR018245; Gonadotropin_bsu_CS.
DR   PANTHER; PTHR11515; PTHR11515; 1.
DR   Pfam; PF00007; Cys_knot; 1.
DR   SMART; SM00068; GHB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR   PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..134
FT                   /note="Thyrotropin subunit beta"
FT                   /id="PRO_0000011756"
FT   CARBOHYD        43
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        22..72
FT                   /evidence="ECO:0000250"
FT   DISULFID        36..87
FT                   /evidence="ECO:0000250"
FT   DISULFID        39..125
FT                   /evidence="ECO:0000250"
FT   DISULFID        47..103
FT                   /evidence="ECO:0000250"
FT   DISULFID        51..105
FT                   /evidence="ECO:0000250"
FT   DISULFID        108..115
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   134 AA;  15065 MW;  3D2429DB4EAC07EB CRC64;
     MSPFFMMSLL FGLTFGQTAS VCAPSEYTIH VEKRECAYCL AINTTICAGF CMTRDSNGKK
     LLLKSALSQN VCTYKEMFYQ TALIPGCPHH TIPYYSYPVA ISCKCGKCNT DYSDCVHEKV
     RTNYCTKPQK LCNM