ID   TSHB_HORSE              Reviewed;         138 AA.
AC   Q28376;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Thyrotropin subunit beta;
DE   AltName: Full=Thyroid-stimulating hormone subunit beta;
DE            Short=TSH-B;
DE            Short=TSH-beta;
DE   AltName: Full=Thyrotropin beta chain;
DE   Flags: Precursor;
GN   Name=TSHB;
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RA   Kania S.A., Olchowy T.W., Frank L.A.;
RL   Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Indispensable for the control of thyroid structure and
CC       metabolism.
CC   -!- SUBUNIT: Heterodimer of a common alpha chain and a unique beta chain
CC       which confers biological specificity to thyrotropin, lutropin,
CC       follitropin and gonadotropin.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC       {ECO:0000305}.
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DR   EMBL; U51789; AAA96826.1; -; mRNA.
DR   RefSeq; NP_001075960.1; NM_001082491.1.
DR   RefSeq; XP_014595481.1; XM_014739995.1.
DR   AlphaFoldDB; Q28376; -.
DR   SMR; Q28376; -.
DR   STRING; 9796.ENSECAP00000010679; -.
DR   PaxDb; Q28376; -.
DR   Ensembl; ENSECAT00000013447; ENSECAP00000010679; ENSECAG00000012981.
DR   GeneID; 100034188; -.
DR   KEGG; ecb:100034188; -.
DR   CTD; 7252; -.
DR   VGNC; VGNC:24580; TSHB.
DR   GeneTree; ENSGT00940000158152; -.
DR   HOGENOM; CLU_126319_0_2_1; -.
DR   InParanoid; Q28376; -.
DR   OMA; PTEYMMH; -.
DR   OrthoDB; 1362225at2759; -.
DR   TreeFam; TF332940; -.
DR   Proteomes; UP000002281; Chromosome 5.
DR   Bgee; ENSECAG00000012981; Expressed in testis.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   CDD; cd00069; GHB_like; 1.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006208; Glyco_hormone_CN.
DR   InterPro; IPR001545; Gonadotropin_bsu.
DR   InterPro; IPR018245; Gonadotropin_bsu_CS.
DR   PANTHER; PTHR11515; PTHR11515; 1.
DR   Pfam; PF00007; Cys_knot; 1.
DR   SMART; SM00068; GHB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR   PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000250"
FT   CHAIN           21..132
FT                   /note="Thyrotropin subunit beta"
FT                   /id="PRO_0000011744"
FT   PROPEP          133..138
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000011745"
FT   CARBOHYD        43
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        22..72
FT                   /evidence="ECO:0000250"
FT   DISULFID        36..87
FT                   /evidence="ECO:0000250"
FT   DISULFID        39..125
FT                   /evidence="ECO:0000250"
FT   DISULFID        47..103
FT                   /evidence="ECO:0000250"
FT   DISULFID        51..105
FT                   /evidence="ECO:0000250"
FT   DISULFID        108..115
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   138 AA;  15663 MW;  B03072B4A1C56BA7 CRC64;
     MTAIFLMSMV FGLACGQTMS FCIPTEYMMH VERKECAYCL TINTTICAGY CMTRDINGKL
     FLPKYALSQD VCTYRDFMYK TVEIPGCPDH VTPYFSYPVA VSCKCGKCNT DYSDCIHEAI
     KANYCTKPQK SYVVEFSI