ID   TSI5_PSEAE              Reviewed;          76 AA.
AC   P0DTB6;
DT   26-FEB-2020, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2020, sequence version 1.
DT   25-MAY-2022, entry version 4.
DE   RecName: Full=Immune protein Tsi5 {ECO:0000303|PubMed:24589350};
GN   Name=tsi5 {ECO:0000303|PubMed:24589350}; OrderedLocusNames=PA2683.1;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=24589350; DOI=10.1111/mmi.12571;
RA   Whitney J.C., Beck C.M., Goo Y.A., Russell A.B., Harding B.N.,
RA   De Leon J.A., Cunningham D.A., Tran B.Q., Low D.A., Goodlett D.R.,
RA   Hayes C.S., Mougous J.D.;
RT   "Genetically distinct pathways guide effector export through the type VI
RT   secretion system.";
RL   Mol. Microbiol. 92:529-542(2014).
CC   -!- FUNCTION: Immunity protein that plays a role in preventing early
CC       activation of toxin Tse5. {ECO:0000269|PubMed:24589350}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- DISRUPTION PHENOTYPE: Deletion mutant together with deletion of toxin
CC       Tse5 leads to a significant loss of fitness advantage when placed in
CC       competition with parental strains. {ECO:0000269|PubMed:24589350}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE004091; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P0DTB6; -.
DR   SMR; P0DTB6; -.
DR   STRING; 287.DR97_5276; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..76
FT                   /note="Immune protein Tsi5"
FT                   /id="PRO_0000449111"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   76 AA;  8759 MW;  64F093F655DC3F55 CRC64;
     MPTEGRRRGV SAAMIKHYLL MTLVCIPLAL LYVCLEWFFG NTWVTVGVFF GVLVVLRLGL
     YLYRRSKGIR DGYLDE