ID   TSI7_PSEAE              Reviewed;         306 AA.
AC   Q9I732;
DT   26-FEB-2020, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Immune protein Tsi7 {ECO:0000303|PubMed:30455305};
GN   Name=tsi7 {ECO:0000303|PubMed:30455305}; OrderedLocusNames=PA0100;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
RN   [2]
RP   FUNCTION, AND INTERACTION WITH TSE7.
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=30455305; DOI=10.1073/pnas.1814181115;
RA   Pissaridou P., Allsopp L.P., Wettstadt S., Howard S.A., Mavridou D.A.I.,
RA   Filloux A.;
RT   "The Pseudomonas aeruginosa T6SS-VgrG1b spike is topped by a PAAR protein
RT   eliciting DNA damage to bacterial competitors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 115:12519-12524(2018).
CC   -!- FUNCTION: Immunity protein that plays a role in preventing early
CC       activation of toxin Tse7. Protects thereby cells from Tse7 DNase
CC       activity. {ECO:0000269|PubMed:30455305}.
CC   -!- SUBUNIT: Interacts with Tse7. {ECO:0000269|PubMed:30455305}.
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DR   EMBL; AE004091; AAG03490.1; -; Genomic_DNA.
DR   PIR; A83634; A83634.
DR   RefSeq; NP_248790.1; NC_002516.2.
DR   RefSeq; WP_003115069.1; NZ_QZGE01000015.1.
DR   AlphaFoldDB; Q9I732; -.
DR   SMR; Q9I732; -.
DR   STRING; 287.DR97_3057; -.
DR   PaxDb; Q9I732; -.
DR   DNASU; 880727; -.
DR   EnsemblBacteria; AAG03490; AAG03490; PA0100.
DR   GeneID; 880727; -.
DR   KEGG; pae:PA0100; -.
DR   PATRIC; fig|208964.12.peg.104; -.
DR   PseudoCAP; PA0100; -.
DR   HOGENOM; CLU_071258_0_1_6; -.
DR   OMA; DENDWRA; -.
DR   BioCyc; PAER208964:G1FZ6-102-MON; -.
DR   Proteomes; UP000002438; Chromosome.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..306
FT                   /note="Immune protein Tsi7"
FT                   /id="PRO_0000449113"
SQ   SEQUENCE   306 AA;  33723 MW;  E9EF587A69005111 CRC64;
     MLKKLSPIFS NITGVVRYQD LAYVASVSDE IQEQNIAHSY VTEWDCGTWC VAGEDDDMLP
     WEIVSATVVH EPVEQALFLG ARGQVFCMGS GDIHEEQLPD GDDAIGGRGN MRGVACIDGV
     AYACGMDRQV YRRFDENDWR AIDTGARPPA GSEAVVGFEA IGGFGAREIY AVGWDGEIWQ
     YDGKRWQPRE SPTNLILTAI CCAEDGSVYA CGQAGTLLRG RNDHWEIIAQ DDVDEDLWSL
     AWFDGALYVS SATAVYTLVG GHLKEVDFGD EQPQRCFHLS AADGVLWSIA AKDIFSFDGQ
     QWTRID