ID   TSIS_WMSV               Reviewed;         226 AA.
AC   P01128; O41283;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   02-JUN-2021, entry version 87.
DE   RecName: Full=PDGF-related-transforming protein sis;
DE   AltName: Full=p28sis;
GN   Name=V-SIS;
OS   Woolly monkey sarcoma virus (WMSV) (Smian sarcoma-associated virus).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Gammaretrovirus.
OX   NCBI_TaxID=11970;
OH   NCBI_TaxID=9518; Lagothrix (woolly monkeys).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6298772; DOI=10.1073/pnas.80.3.731;
RA   Devare S.G., Reddy E.P., Law J.D., Robbins K.C., Aaronson S.A.;
RT   "Nucleotide sequence of the simian sarcoma virus genome: demonstration that
RT   its acquired cellular sequences encode the transforming gene product
RT   p28sis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 80:731-735(1983).
CC   -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA24516.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; V01201; CAA24516.1; ALT_INIT; Genomic_DNA.
DR   PIR; A01381; TVMVSS.
DR   RefSeq; YP_001165471.2; NC_009424.4.
DR   RefSeq; YP_003580185.1; NC_009424.4.
DR   SMR; P01128; -.
DR   GeneID; 5176147; -.
DR   KEGG; vg:5176147; -.
DR   Proteomes; UP000203831; Genome.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   CDD; cd00135; PDGF; 1.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR023581; PD_growth_factor_CS.
DR   InterPro; IPR000072; PDGF/VEGF_dom.
DR   InterPro; IPR006782; PDGF_N.
DR   InterPro; IPR015583; PDGF_suB.
DR   PANTHER; PTHR11633:SF2; PTHR11633:SF2; 1.
DR   Pfam; PF00341; PDGF; 1.
DR   Pfam; PF04692; PDGF_N; 1.
DR   SMART; SM00141; PDGF; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00249; PDGF_1; 1.
DR   PROSITE; PS50278; PDGF_2; 1.
PE   3: Inferred from homology;
KW   Growth factor; Oncogene.
FT   CHAIN           1..226
FT                   /note="PDGF-related-transforming protein sis"
FT                   /id="PRO_0000162360"
FT   REGION          201..226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        201..215
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   226 AA;  25411 MW;  A16813ABB95B90C5 CRC64;
     MTLTWQGDPI PEELYKMLSG HSIRSFDDLQ RLLQGDSGKE DGAELDLNMT RSHSGGELES
     LARGKRSLGS LSVAEPAMIA ECKTRTEVFE ISRRLIDRTN ANFLVWPPCV EVQRCSGCCN
     NRNVQCRPTQ VQLRPVQVRK IEIVRKKPIF KKATVTLEDH LACKCEIVAA ARAVTRSPGT
     SQEQRAKTTQ SRVTIRTVRV RRPPKGKHRK CKHTHDKTAL KETLGA