ID   TSIV1_VIBCH             Reviewed;         247 AA.
AC   Q9KS42;
DT   26-FEB-2020, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Immunity protein TsiV1 {ECO:0000303|PubMed:24348240};
GN   Name=tsiV1 {ECO:0000303|PubMed:24348240}; OrderedLocusNames=VC_1419;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=24348240; DOI=10.1371/journal.ppat.1003752;
RA   Miyata S.T., Unterweger D., Rudko S.P., Pukatzki S.;
RT   "Dual expression profile of type VI secretion system immunity genes
RT   protects pandemic Vibrio cholerae.";
RL   PLoS Pathog. 9:E1003752-E1003752(2013).
CC   -!- FUNCTION: Immunity protein that plays a role in preventing early
CC       activation of toxin TseL. {ECO:0000269|PubMed:24348240}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC       protein {ECO:0000255}.
CC   -!- DISRUPTION PHENOTYPE: Deletion mutant is susceptible to killing by V52
CC       strain in a TseL-dependent manner. {ECO:0000269|PubMed:24348240}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE003852; AAF94576.1; -; Genomic_DNA.
DR   PIR; G82202; G82202.
DR   RefSeq; NP_231062.1; NC_002505.1.
DR   RefSeq; WP_000771534.1; NZ_LT906614.1.
DR   AlphaFoldDB; Q9KS42; -.
DR   STRING; 243277.VC_1419; -.
DR   DNASU; 2614051; -.
DR   EnsemblBacteria; AAF94576; AAF94576; VC_1419.
DR   GeneID; 57740071; -.
DR   KEGG; vch:VC_1419; -.
DR   PATRIC; fig|243277.26.peg.1348; -.
DR   eggNOG; ENOG5031N1V; Bacteria.
DR   HOGENOM; CLU_1155304_0_0_6; -.
DR   OMA; RARYYED; -.
DR   BioCyc; VCHO:VC1419-MON; -.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..247
FT                   /note="Immunity protein TsiV1"
FT                   /id="PRO_0000449207"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   247 AA;  28474 MW;  0CC2930911DFF922 CRC64;
     MKLLNNLAIK KLISVVVLFI ALFFLGYDYY QTSQPNIWGD EPDESYITIS GKKPIDAYLE
     VWTHFWVTGD ECEAYSYDLF GQKAHQGGKI SQKITHDFAK DGSNFEFRIP YQTYKNSQNC
     IVELRDFSIQ AHNDFDTVGF AQLRFSPAGR EYYNREVDLN SLITADNCNS DIFKSIRKEW
     AGAIGCHFYV DGKKKTKDEE FNAYTIYYDF SKFNNDTVIH YDILAGENYR SEPLSSAQKT
     AVVSDDN