TSN11_HUMAN
ID TSN11_HUMAN Reviewed; 253 AA.
AC A1L157; A1L158; B2RUX6;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Tetraspanin-11;
DE Short=Tspan-11;
GN Name=TSPAN11;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-190.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR EMBL; AC008013; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC008150; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC127660; AAI27661.1; -; mRNA.
DR EMBL; BC127661; AAI27662.1; -; mRNA.
DR EMBL; BC146917; AAI46918.1; -; mRNA.
DR EMBL; BC146922; AAI46923.1; -; mRNA.
DR CCDS; CCDS31765.1; -.
DR RefSeq; NP_001073978.1; NM_001080509.2.
DR RefSeq; XP_011518982.1; XM_011520680.2.
DR AlphaFoldDB; A1L157; -.
DR SMR; A1L157; -.
DR BioGRID; 137636; 35.
DR IntAct; A1L157; 11.
DR STRING; 9606.ENSP00000261177; -.
DR GlyGen; A1L157; 1 site.
DR PhosphoSitePlus; A1L157; -.
DR SwissPalm; A1L157; -.
DR BioMuta; TSPAN11; -.
DR jPOST; A1L157; -.
DR MassIVE; A1L157; -.
DR MaxQB; A1L157; -.
DR PaxDb; A1L157; -.
DR PeptideAtlas; A1L157; -.
DR PRIDE; A1L157; -.
DR ProteomicsDB; 130; -.
DR Antibodypedia; 42427; 31 antibodies from 15 providers.
DR DNASU; 441631; -.
DR Ensembl; ENST00000261177.10; ENSP00000261177.9; ENSG00000110900.16.
DR Ensembl; ENST00000546076.6; ENSP00000437403.1; ENSG00000110900.16.
DR GeneID; 441631; -.
DR KEGG; hsa:441631; -.
DR MANE-Select; ENST00000546076.6; ENSP00000437403.1; NM_001370302.1; NP_001357231.1.
DR UCSC; uc001rjp.4; human.
DR CTD; 441631; -.
DR DisGeNET; 441631; -.
DR GeneCards; TSPAN11; -.
DR HGNC; HGNC:30795; TSPAN11.
DR HPA; ENSG00000110900; Tissue enhanced (intestine).
DR neXtProt; NX_A1L157; -.
DR OpenTargets; ENSG00000110900; -.
DR PharmGKB; PA142670687; -.
DR VEuPathDB; HostDB:ENSG00000110900; -.
DR eggNOG; KOG3882; Eukaryota.
DR GeneTree; ENSGT00940000161249; -.
DR HOGENOM; CLU_055524_5_0_1; -.
DR InParanoid; A1L157; -.
DR OMA; CMAKLEQ; -.
DR OrthoDB; 1051357at2759; -.
DR PhylomeDB; A1L157; -.
DR TreeFam; TF352892; -.
DR PathwayCommons; A1L157; -.
DR SignaLink; A1L157; -.
DR BioGRID-ORCS; 441631; 13 hits in 1063 CRISPR screens.
DR ChiTaRS; TSPAN11; human.
DR GenomeRNAi; 441631; -.
DR Pharos; A1L157; Tdark.
DR PRO; PR:A1L157; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; A1L157; protein.
DR Bgee; ENSG00000110900; Expressed in tendon of biceps brachii and 125 other tissues.
DR ExpressionAtlas; A1L157; baseline and differential.
DR Genevisible; A1L157; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR Gene3D; 1.10.1450.10; -; 1.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR000301; Tetraspanin_animals.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR PANTHER; PTHR19282; PTHR19282; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PIRSF; PIRSF002419; Tetraspanin; 1.
DR SUPFAM; SSF48652; SSF48652; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..253
FT /note="Tetraspanin-11"
FT /id="PRO_0000311905"
FT TRANSMEM 19..39
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 127
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 190
FT /note="V -> A (in dbSNP:rs2075333)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_037337"
SQ SEQUENCE 253 AA; 28245 MW; 231635F1B4117C92 CRC64;
MAHYKTEQDD WLIIYLKYLL FVFNFFFWVG GAAVLAVGIW TLVEKSGYLS VLASSTFAAS
AYILIFAGVL VMVTGFLGFG AILWERKGCL STYFCLLLVI FLVELVAGVL AHVYYQRLSD
ELKQHLNRTL AENYGQPGAT QITASVDRLQ QDFKCCGSNS SADWQHSTYI LLREAEGRQV
PDSCCKTVVV RCGQRAHPSN IYKVEGGCLT KLEQFLADHL LLMGAVGIGV ACLQICGMVL
TCCLHQRLQR HFY
