TSN11_MOUSE
ID TSN11_MOUSE Reviewed; 253 AA.
AC Q9D1D1;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Tetraspanin-11;
DE Short=Tspan-11;
GN Name=Tspan11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Colon, Eye, and Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR EMBL; AK003691; BAB22942.1; -; mRNA.
DR EMBL; AK028808; BAC26129.1; -; mRNA.
DR EMBL; AK053788; BAC35523.1; -; mRNA.
DR EMBL; AK090022; BAC41051.1; -; mRNA.
DR EMBL; BC057639; AAH57639.1; -; mRNA.
DR CCDS; CCDS20567.1; -.
DR RefSeq; NP_081019.1; NM_026743.3.
DR AlphaFoldDB; Q9D1D1; -.
DR SMR; Q9D1D1; -.
DR STRING; 10090.ENSMUSP00000032501; -.
DR GlyGen; Q9D1D1; 1 site.
DR PhosphoSitePlus; Q9D1D1; -.
DR PaxDb; Q9D1D1; -.
DR PRIDE; Q9D1D1; -.
DR ProteomicsDB; 297982; -.
DR Antibodypedia; 42427; 31 antibodies from 15 providers.
DR DNASU; 68498; -.
DR Ensembl; ENSMUST00000032501; ENSMUSP00000032501; ENSMUSG00000030351.
DR GeneID; 68498; -.
DR KEGG; mmu:68498; -.
DR UCSC; uc009ecn.1; mouse.
DR CTD; 441631; -.
DR MGI; MGI:1915748; Tspan11.
DR VEuPathDB; HostDB:ENSMUSG00000030351; -.
DR eggNOG; KOG3882; Eukaryota.
DR GeneTree; ENSGT00940000161249; -.
DR HOGENOM; CLU_055524_5_0_1; -.
DR InParanoid; Q9D1D1; -.
DR OMA; CMAKLEQ; -.
DR OrthoDB; 1051357at2759; -.
DR PhylomeDB; Q9D1D1; -.
DR TreeFam; TF352892; -.
DR BioGRID-ORCS; 68498; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q9D1D1; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9D1D1; protein.
DR Bgee; ENSMUSG00000030351; Expressed in ascending aorta and 102 other tissues.
DR Genevisible; Q9D1D1; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR Gene3D; 1.10.1450.10; -; 1.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR000301; Tetraspanin_animals.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR PANTHER; PTHR19282; PTHR19282; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PIRSF; PIRSF002419; Tetraspanin; 1.
DR SUPFAM; SSF48652; SSF48652; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..253
FT /note="Tetraspanin-11"
FT /id="PRO_0000311906"
FT TRANSMEM 19..39
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 127
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 253 AA; 28072 MW; 8A820157A945C60A CRC64;
MAHCKTEQDD WLLAHLKYLL FIFNFFFWVG GAAVMAVGIW TLVEKSGYLS ILASSTFAAS
AYILIFVGGL VMTTGFLGFG AIIREQKSCL STYFCLLLVI FLVELVAGVL AHVYYQRLSD
ELKWHLNSTL TEHYGQPRAA EITASVDRLQ QDFKCCGSNS SADWQHSAYI LSQEALGRQV
PDSCCKTVVA RCGQRAHPSN IYKVEGGCMA KLEQFVADHL LLMGAVGIGV ACLQICGMVL
TCCLHRRLQQ QFY
