TSN13_MOUSE
ID TSN13_MOUSE Reviewed; 204 AA.
AC Q9D8C2; A7NSH9; Q3TMS0; Q8BTH3;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Tetraspanin-13;
DE Short=Tspan-13;
DE AltName: Full=Transmembrane 4 superfamily member 13;
GN Name=Tspan13; Synonyms=Tm4sf13;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and DBA/2J;
RC TISSUE=Brain, Placenta, Seminal vesicle, and Visual cortex;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung, and Pancreas;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR EMBL; AK008175; BAB25510.1; -; mRNA.
DR EMBL; AK090217; BAC41139.1; -; mRNA.
DR EMBL; AK090322; BAC41170.1; -; mRNA.
DR EMBL; AK158761; BAE34648.1; -; mRNA.
DR EMBL; AK165768; BAE38371.1; -; mRNA.
DR EMBL; AK167495; BAE39572.1; -; mRNA.
DR EMBL; AK167979; BAE39971.1; -; mRNA.
DR EMBL; CT030196; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC018317; AAH18317.1; -; mRNA.
DR CCDS; CCDS25882.1; -.
DR RefSeq; NP_079635.1; NM_025359.3.
DR AlphaFoldDB; Q9D8C2; -.
DR SMR; Q9D8C2; -.
DR STRING; 10090.ENSMUSP00000020896; -.
DR TCDB; 8.A.40.1.8; the tetraspanin (tetraspanin) family.
DR GlyConnect; 2759; 1 N-Linked glycan (1 site).
DR GlyGen; Q9D8C2; 2 sites, 1 N-linked glycan (1 site).
DR iPTMnet; Q9D8C2; -.
DR PhosphoSitePlus; Q9D8C2; -.
DR SwissPalm; Q9D8C2; -.
DR EPD; Q9D8C2; -.
DR MaxQB; Q9D8C2; -.
DR PaxDb; Q9D8C2; -.
DR PRIDE; Q9D8C2; -.
DR ProteomicsDB; 297983; -.
DR Antibodypedia; 25268; 109 antibodies from 22 providers.
DR DNASU; 66109; -.
DR Ensembl; ENSMUST00000020896; ENSMUSP00000020896; ENSMUSG00000020577.
DR GeneID; 66109; -.
DR KEGG; mmu:66109; -.
DR UCSC; uc007njn.1; mouse.
DR CTD; 27075; -.
DR MGI; MGI:1913359; Tspan13.
DR VEuPathDB; HostDB:ENSMUSG00000020577; -.
DR eggNOG; KOG3882; Eukaryota.
DR GeneTree; ENSGT00940000157010; -.
DR HOGENOM; CLU_088363_0_0_1; -.
DR InParanoid; Q9D8C2; -.
DR OMA; CPPCAPI; -.
DR OrthoDB; 1203231at2759; -.
DR PhylomeDB; Q9D8C2; -.
DR TreeFam; TF323367; -.
DR BioGRID-ORCS; 66109; 1 hit in 74 CRISPR screens.
DR ChiTaRS; Tspan13; mouse.
DR PRO; PR:Q9D8C2; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q9D8C2; protein.
DR Bgee; ENSMUSG00000020577; Expressed in habenula and 274 other tissues.
DR ExpressionAtlas; Q9D8C2; baseline and differential.
DR Genevisible; Q9D8C2; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR GO; GO:0005246; F:calcium channel regulator activity; IDA:MGI.
DR GO; GO:1903169; P:regulation of calcium ion transmembrane transport; IDA:MGI.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR000301; Tetraspanin_animals.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR PANTHER; PTHR19282; PTHR19282; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PIRSF; PIRSF002419; Tetraspanin; 1.
DR SUPFAM; SSF48652; SSF48652; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..204
FT /note="Tetraspanin-13"
FT /id="PRO_0000219259"
FT TOPO_DOM 1..19
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 41..44
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 66..72
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94..167
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 189..204
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 143
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CARBOHYD 113
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000250"
FT CARBOHYD 137
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000250"
FT CONFLICT 97
FT /note="L -> S (in Ref. 1; BAC41170)"
FT /evidence="ECO:0000305"
FT CONFLICT 157
FT /note="I -> M (in Ref. 1; BAC41170)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 204 AA; 22219 MW; 76B95421EBCAE5F0 CRC64;
MVCGGFSCSK NCLCALNLLY TLVSLLLIGI AAWGIGFGLI SSLRVVGVVI AVGIFLFLIA
LVGLIGAVKH HQVLLFFYMI ILLLVFIVQF SVSCACLALN REQQGQLLEV GWNNTASARN
DIQRNLNCCG FRSYNPNDTC PASCAKSTQK CSSCAPIIGE YAGEVLRFVG GIGLFFSFTE
ILGVWLTYRY RNQKDPRANP SAFL
