TSN17_HUMAN
ID TSN17_HUMAN Reviewed; 270 AA.
AC Q96FV3; Q6NXF7; Q96S98; Q9UKB9;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Tetraspanin-17;
DE Short=Tspan-17;
DE AltName: Full=F-box only protein 23;
DE AltName: Full=Tetraspan protein SB134;
DE AltName: Full=Transmembrane 4 superfamily member 17;
GN Name=TSPAN17; Synonyms=FBXO23, TM4SF17;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
RA Zhang W., Li N., Wan T., Cao X.;
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
RC TISSUE=Mammary gland, and Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-110 (ISOFORMS 1/3/4).
RX PubMed=10531035; DOI=10.1016/s0960-9822(00)80020-2;
RA Cenciarelli C., Chiaur D.S., Guardavaccaro D., Parks W., Vidal M.,
RA Pagano M.;
RT "Identification of a family of human F-box proteins.";
RL Curr. Biol. 9:1177-1179(1999).
CC -!- FUNCTION: Regulates ADAM10 maturation. {ECO:0000250|UniProtKB:Q9D7W4}.
CC -!- SUBUNIT: Interacts with ADAM10. {ECO:0000250|UniProtKB:Q9D7W4}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q96FV3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96FV3-3; Sequence=VSP_011391;
CC Name=3;
CC IsoId=Q96FV3-2; Sequence=VSP_011388, VSP_011389, VSP_011390;
CC Name=4;
CC IsoId=Q96FV3-4; Sequence=VSP_025608;
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF04524.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY037146; AAK67627.1; -; mRNA.
DR EMBL; AC091934; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC010405; AAH10405.1; -; mRNA.
DR EMBL; BC067105; AAH67105.1; -; mRNA.
DR EMBL; AF174603; AAF04524.1; ALT_FRAME; mRNA.
DR CCDS; CCDS47346.2; -. [Q96FV3-3]
DR CCDS; CCDS54952.1; -. [Q96FV3-4]
DR RefSeq; NP_001006617.2; NM_001006616.2. [Q96FV3-3]
DR RefSeq; NP_569732.2; NM_130465.4. [Q96FV3-4]
DR AlphaFoldDB; Q96FV3; -.
DR SMR; Q96FV3; -.
DR BioGRID; 117648; 76.
DR IntAct; Q96FV3; 28.
DR STRING; 9606.ENSP00000309036; -.
DR GlyGen; Q96FV3; 2 sites.
DR iPTMnet; Q96FV3; -.
DR BioMuta; TSPAN17; -.
DR DMDM; 147744595; -.
DR EPD; Q96FV3; -.
DR MassIVE; Q96FV3; -.
DR PaxDb; Q96FV3; -.
DR PeptideAtlas; Q96FV3; -.
DR PRIDE; Q96FV3; -.
DR ProteomicsDB; 76560; -. [Q96FV3-1]
DR ProteomicsDB; 76562; -. [Q96FV3-3]
DR ProteomicsDB; 76563; -. [Q96FV3-4]
DR Antibodypedia; 29134; 94 antibodies from 21 providers.
DR DNASU; 26262; -.
DR Ensembl; ENST00000298564.14; ENSP00000298564.10; ENSG00000048140.18. [Q96FV3-2]
DR Ensembl; ENST00000508164.6; ENSP00000422053.1; ENSG00000048140.18. [Q96FV3-4]
DR Ensembl; ENST00000515708.5; ENSP00000426650.1; ENSG00000048140.18. [Q96FV3-3]
DR GeneID; 26262; -.
DR KEGG; hsa:26262; -.
DR MANE-Select; ENST00000508164.6; ENSP00000422053.1; NM_130465.5; NP_569732.2. [Q96FV3-4]
DR UCSC; uc003mes.4; human. [Q96FV3-1]
DR CTD; 26262; -.
DR DisGeNET; 26262; -.
DR GeneCards; TSPAN17; -.
DR HGNC; HGNC:13594; TSPAN17.
DR HPA; ENSG00000048140; Low tissue specificity.
DR neXtProt; NX_Q96FV3; -.
DR OpenTargets; ENSG00000048140; -.
DR PharmGKB; PA128394740; -.
DR VEuPathDB; HostDB:ENSG00000048140; -.
DR eggNOG; KOG3882; Eukaryota.
DR GeneTree; ENSGT00940000155429; -.
DR InParanoid; Q96FV3; -.
DR OMA; SRKHHHF; -.
DR OrthoDB; 1180379at2759; -.
DR PhylomeDB; Q96FV3; -.
DR PathwayCommons; Q96FV3; -.
DR SignaLink; Q96FV3; -.
DR BioGRID-ORCS; 26262; 16 hits in 1085 CRISPR screens.
DR ChiTaRS; TSPAN17; human.
DR GenomeRNAi; 26262; -.
DR Pharos; Q96FV3; Tdark.
DR PRO; PR:Q96FV3; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q96FV3; protein.
DR Bgee; ENSG00000048140; Expressed in right adrenal gland and 183 other tissues.
DR ExpressionAtlas; Q96FV3; baseline and differential.
DR Genevisible; Q96FV3; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0000151; C:ubiquitin ligase complex; NAS:UniProtKB.
DR GO; GO:0019899; F:enzyme binding; IPI:UniProtKB.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; NAS:UniProtKB.
DR GO; GO:0072594; P:establishment of protein localization to organelle; IDA:UniProtKB.
DR GO; GO:0072659; P:protein localization to plasma membrane; IBA:GO_Central.
DR GO; GO:0051604; P:protein maturation; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; NAS:UniProtKB.
DR Gene3D; 1.10.1450.10; -; 1.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR000301; Tetraspanin_animals.
DR InterPro; IPR018503; Tetraspanin_CS.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR PANTHER; PTHR19282; PTHR19282; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PIRSF; PIRSF002419; Tetraspanin; 1.
DR SUPFAM; SSF48652; SSF48652; 1.
DR PROSITE; PS00421; TM4_1; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..270
FT /note="Tetraspanin-17"
FT /id="PRO_0000219265"
FT TOPO_DOM 1..19
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 41..63
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 85..94
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 116..234
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 256..270
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 51
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 171
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 30..95
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_011388"
FT VAR_SEQ 153..194
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_011389"
FT VAR_SEQ 249
FT /note="Q -> QVPLWPHVPLPLPGPPSLSPHLSSVLQ (in isoform 3)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_011390"
FT VAR_SEQ 260..270
FT /note="VSDIKAVKANW -> EQME (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_011391"
FT VAR_SEQ 270
FT /note="W -> WSKWNDDFENHWLTPTISEVLSTAGPQQNSLTGAPGPAPPSRHVFFG
FT LGGLYPEPTFKNW (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_025608"
FT VARIANT 140
FT /note="I -> T (in dbSNP:rs17624798)"
FT /id="VAR_057278"
FT CONFLICT 239
FT /note="A -> P (in Ref. 1; AAK67627)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 270 AA; 30264 MW; 157F76DF059D9E19 CRC64;
MPGKHQHFQE PEVGCCGKYF LFGFNIVFWV LGALFLAIGL WAWGEKGVLS NISALTDLGG
LDPVWLFVVV GGVMSVLGFA GCIGALRENT FLLKFFSVFL GLIFFLELAT GILAFVFKDW
IRDQLNLFIN NNVKAYRDDI DLQNLIDFAQ EYWSCCGARG PNDWNLNIYF NCTDLNPSRE
RCGVPFSCCV RDPAEDVLNT QCGYDVRLKL ELEQQGFIHT KGCVGQFEKW LQDNLIVVAG
VFMGIALLQI FGICLAQNLV SDIKAVKANW
