ID   TSN17_RAT               Reviewed;         270 AA.
AC   Q4V8E0;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Tetraspanin-17;
DE            Short=Tspan-17;
DE   AltName: Full=F-box only protein 23;
GN   Name=Tspan17; Synonyms=Fbxo23;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Regulates ADAM10 maturation. {ECO:0000250|UniProtKB:Q9D7W4}.
CC   -!- SUBUNIT: Interacts with ADAM10. {ECO:0000250|UniProtKB:Q9D7W4}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR   EMBL; BC097431; AAH97431.1; -; mRNA.
DR   RefSeq; NP_001013156.2; NM_001013138.2.
DR   AlphaFoldDB; Q4V8E0; -.
DR   SMR; Q4V8E0; -.
DR   STRING; 10116.ENSRNOP00000049736; -.
DR   GlyGen; Q4V8E0; 2 sites.
DR   PaxDb; Q4V8E0; -.
DR   GeneID; 306771; -.
DR   KEGG; rno:306771; -.
DR   UCSC; RGD:1311167; rat.
DR   CTD; 26262; -.
DR   RGD; 1311167; Tspan17.
DR   VEuPathDB; HostDB:ENSRNOG00000018122; -.
DR   eggNOG; KOG3882; Eukaryota.
DR   HOGENOM; CLU_055524_0_2_1; -.
DR   InParanoid; Q4V8E0; -.
DR   PhylomeDB; Q4V8E0; -.
DR   PRO; PR:Q4V8E0; -.
DR   Proteomes; UP000002494; Chromosome 17.
DR   Bgee; ENSRNOG00000018122; Expressed in frontal cortex and 19 other tissues.
DR   ExpressionAtlas; Q4V8E0; baseline and differential.
DR   Genevisible; Q4V8E0; RN.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0019899; F:enzyme binding; ISO:RGD.
DR   GO; GO:0072594; P:establishment of protein localization to organelle; ISO:RGD.
DR   GO; GO:0072659; P:protein localization to plasma membrane; IBA:GO_Central.
DR   GO; GO:0051604; P:protein maturation; ISO:RGD.
DR   Gene3D; 1.10.1450.10; -; 1.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR000301; Tetraspanin_animals.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2_sf.
DR   PANTHER; PTHR19282; PTHR19282; 1.
DR   Pfam; PF00335; Tetraspanin; 1.
DR   PIRSF; PIRSF002419; Tetraspanin; 1.
DR   SUPFAM; SSF48652; SSF48652; 1.
DR   PROSITE; PS00421; TM4_1; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..270
FT                   /note="Tetraspanin-17"
FT                   /id="PRO_0000287715"
FT   TOPO_DOM        1..19
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        41..63
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        85..94
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        116..234
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        256..270
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        51
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        171
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   270 AA;  30110 MW;  E02ED6857CE7E1B8 CRC64;
     MPGKHQQFQD PEVGCCGKYF LFGFNIVFWV LGALFLAIGL WAWGEKGVLS NISGLTDLGG
     LDPVWLFVVI GGIMSVLGFA GCIGALRENT FLLKFFSVFL GLIFFLELAA GILAFVFKDW
     IRDQLNLFIN NNVKAYRDDI DLQNLIDFAQ EYWSCCGARG PNDWNLNIYF NCTDLNPSRE
     RCGVPFSCCV RDPAEDVLNT QCGYDIRLKL ELEQQGSIYT KGCVGQFEKW LQDNLIVVAG
     VLVAIALLQI CGICLAQNLV SDIEAVKANW