ID   TSN18_BOVIN             Reviewed;         249 AA.
AC   Q58CY8;
DT   21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Tetraspanin-18;
DE            Short=Tspan-18;
GN   Name=TSPAN18;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR   EMBL; BT021809; AAX46656.1; -; mRNA.
DR   RefSeq; NP_001074389.1; NM_001080920.1.
DR   AlphaFoldDB; Q58CY8; -.
DR   SMR; Q58CY8; -.
DR   STRING; 9913.ENSBTAP00000028636; -.
DR   PaxDb; Q58CY8; -.
DR   PRIDE; Q58CY8; -.
DR   Ensembl; ENSBTAT00000028636; ENSBTAP00000028636; ENSBTAG00000021484.
DR   GeneID; 783765; -.
DR   KEGG; bta:783765; -.
DR   CTD; 90139; -.
DR   VEuPathDB; HostDB:ENSBTAG00000021484; -.
DR   VGNC; VGNC:36433; TSPAN18.
DR   eggNOG; KOG3882; Eukaryota.
DR   GeneTree; ENSGT00940000157667; -.
DR   InParanoid; Q58CY8; -.
DR   OMA; ACCQREP; -.
DR   OrthoDB; 1232467at2759; -.
DR   Proteomes; UP000009136; Chromosome 15.
DR   Bgee; ENSBTAG00000021484; Expressed in vas deferens and 100 other tissues.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   Gene3D; 1.10.1450.10; -; 1.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR000301; Tetraspanin_animals.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2_sf.
DR   PANTHER; PTHR19282; PTHR19282; 1.
DR   Pfam; PF00335; Tetraspanin; 1.
DR   PIRSF; PIRSF002419; Tetraspanin; 1.
DR   SUPFAM; SSF48652; SSF48652; 1.
DR   PROSITE; PS00421; TM4_1; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..249
FT                   /note="Tetraspanin-18"
FT                   /id="PRO_0000219267"
FT   TOPO_DOM        1..13
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        35..49
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        71..83
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        105..223
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        245..249
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        111
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        129
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   249 AA;  27710 MW;  5ABB0014CCD55485 CRC64;
     MEGDCLSCMK YLMFVFNFFI FLGGACLLGI GIWVMVDPTG FREIVAANPL LITGAYILLA
     MGGLLFLLGF LGCCGAVREN KCLLLFFFLF ILIIFLAELS AAILAFIFRG NLTREFFTKE
     LTKHYQGSND TDVFSATWNS VMITFGCCGV NGPEDFKYAS VFRLLTLDSD EVPEACCRRE
     PQSRDGVLLS REECLLGRDL FLNKQGCYTV ILNAFETYVY LAGALAIGVL AIELFAMIFA
     MCLFRGIIQ