TSN18_HUMAN
ID TSN18_HUMAN Reviewed; 248 AA.
AC Q96SJ8; Q6UY44; Q8NBI9;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Tetraspanin-18;
DE Short=Tspan-18;
GN Name=TSPAN18; ORFNames=UNQ3042/PRO9858;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ILE-133.
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC11690.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK027715; BAB55318.1; -; mRNA.
DR EMBL; AK075547; BAC11690.1; ALT_INIT; mRNA.
DR EMBL; AY358087; AAQ88454.1; -; mRNA.
DR CCDS; CCDS7910.1; -.
DR RefSeq; NP_570139.3; NM_130783.4.
DR RefSeq; XP_006718436.1; XM_006718373.3.
DR RefSeq; XP_011518761.1; XM_011520459.2.
DR AlphaFoldDB; Q96SJ8; -.
DR SMR; Q96SJ8; -.
DR BioGRID; 124669; 27.
DR IntAct; Q96SJ8; 2.
DR STRING; 9606.ENSP00000339820; -.
DR TCDB; 8.A.40.1.23; the tetraspanin (tetraspanin) family.
DR GlyGen; Q96SJ8; 2 sites.
DR SwissPalm; Q96SJ8; -.
DR BioMuta; TSPAN18; -.
DR DMDM; 68053316; -.
DR EPD; Q96SJ8; -.
DR jPOST; Q96SJ8; -.
DR MassIVE; Q96SJ8; -.
DR PaxDb; Q96SJ8; -.
DR PeptideAtlas; Q96SJ8; -.
DR PRIDE; Q96SJ8; -.
DR ProteomicsDB; 78117; -.
DR Antibodypedia; 68460; 62 antibodies from 10 providers.
DR DNASU; 90139; -.
DR Ensembl; ENST00000340160.7; ENSP00000339820.3; ENSG00000157570.12.
DR Ensembl; ENST00000520358.7; ENSP00000429993.2; ENSG00000157570.12.
DR GeneID; 90139; -.
DR KEGG; hsa:90139; -.
DR MANE-Select; ENST00000520358.7; ENSP00000429993.2; NM_130783.5; NP_570139.3.
DR UCSC; uc001mye.5; human.
DR CTD; 90139; -.
DR DisGeNET; 90139; -.
DR GeneCards; TSPAN18; -.
DR HGNC; HGNC:20660; TSPAN18.
DR HPA; ENSG00000157570; Tissue enhanced (heart).
DR MIM; 619399; gene.
DR neXtProt; NX_Q96SJ8; -.
DR OpenTargets; ENSG00000157570; -.
DR PharmGKB; PA142670688; -.
DR VEuPathDB; HostDB:ENSG00000157570; -.
DR eggNOG; KOG3882; Eukaryota.
DR GeneTree; ENSGT00940000157667; -.
DR HOGENOM; CLU_055524_4_1_1; -.
DR InParanoid; Q96SJ8; -.
DR OMA; ACCQREP; -.
DR OrthoDB; 1232467at2759; -.
DR PhylomeDB; Q96SJ8; -.
DR TreeFam; TF352892; -.
DR PathwayCommons; Q96SJ8; -.
DR SignaLink; Q96SJ8; -.
DR BioGRID-ORCS; 90139; 15 hits in 1076 CRISPR screens.
DR ChiTaRS; TSPAN18; human.
DR GenomeRNAi; 90139; -.
DR Pharos; Q96SJ8; Tbio.
DR PRO; PR:Q96SJ8; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q96SJ8; protein.
DR Bgee; ENSG00000157570; Expressed in cardiac muscle of right atrium and 136 other tissues.
DR ExpressionAtlas; Q96SJ8; baseline and differential.
DR Genevisible; Q96SJ8; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR Gene3D; 1.10.1450.10; -; 1.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR000301; Tetraspanin_animals.
DR InterPro; IPR018503; Tetraspanin_CS.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR PANTHER; PTHR19282; PTHR19282; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PIRSF; PIRSF002419; Tetraspanin; 1.
DR SUPFAM; SSF48652; SSF48652; 1.
DR PROSITE; PS00421; TM4_1; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..248
FT /note="Tetraspanin-18"
FT /id="PRO_0000219268"
FT TOPO_DOM 1..13
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 35..49
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..83
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 105..223
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 245..248
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 111
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 129
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 133
FT /note="V -> I (in dbSNP:rs2291334)"
FT /evidence="ECO:0000269|PubMed:12975309"
FT /id="VAR_057279"
SQ SEQUENCE 248 AA; 27710 MW; 6E2869E9D1D35C8E CRC64;
MEGDCLSCMK YLMFVFNFFI FLGGACLLAI GIWVMVDPTG FREIVAANPL LLTGAYILLA
MGGLLFLLGF LGCCGAVREN KCLLLFFFLF ILIIFLAELS AAILAFIFRE NLTREFFTKE
LTKHYQGNND TDVFSATWNS VMITFGCCGV NGPEDFKFAS VFRLLTLDSE EVPEACCRRE
PQSRDGVLLS REECLLGRSL FLNKQGCYTV ILNTFETYVY LAGALAIGVL AIELFAMIFA
MCLFRGIQ
