C3H69_ARATH
ID C3H69_ARATH Reviewed; 350 AA.
AC E0X9N4;
DT 25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=Putative RING-type E3 ubiquitin transferase C3H69 {ECO:0000305};
DE EC=2.3.2.27 {ECO:0000305};
DE AltName: Full=Zinc finger CCCH domain-containing protein 69;
DE Short=AtC3H69;
GN OrderedLocusNames=At3g63550;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Columbia, and cv. Wassilewskija;
RX PubMed=20652368; DOI=10.1007/s11103-010-9664-x;
RA Wang C.T., Ho C.H., Hseu M.J., Chen C.M.;
RT "The subtelomeric region of the Arabidopsis thaliana chromosome IIIR
RT contains potential genes and duplicated fragments from other chromosomes.";
RL Plant Mol. Biol. 74:155-166(2010).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NOMENCLATURE.
RX PubMed=18221561; DOI=10.1186/1471-2164-9-44;
RA Wang D., Guo Y., Wu C., Yang G., Li Y., Zheng C.;
RT "Genome-wide analysis of CCCH zinc finger family in Arabidopsis and rice.";
RL BMC Genomics 9:44-44(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000305};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; GQ903575; ADM35936.1; -; Genomic_DNA.
DR EMBL; GQ903576; ADM35941.1; -; Genomic_DNA.
DR EMBL; CP002686; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; E0X9N4; -.
DR PeptideAtlas; E0X9N4; -.
DR PRIDE; E0X9N4; -.
DR Araport; AT3G63550; -.
DR InParanoid; E0X9N4; -.
DR PRO; PR:E0X9N4; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; E0X9N4; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR045072; MKRN-like.
DR InterPro; IPR041367; Znf-CCCH_4.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR036855; Znf_CCCH_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR11224; PTHR11224; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR Pfam; PF18044; zf-CCCH_4; 2.
DR SMART; SM00184; RING; 1.
DR SMART; SM00356; ZnF_C3H1; 4.
DR SUPFAM; SSF90229; SSF90229; 2.
DR PROSITE; PS50103; ZF_C3H1; 4.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transferase; Zinc; Zinc-finger.
FT CHAIN 1..350
FT /note="Putative RING-type E3 ubiquitin transferase C3H69"
FT /id="PRO_0000414862"
FT ZN_FING 1..28
FT /note="C3H1-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 29..56
FT /note="C3H1-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 129..156
FT /note="C3H1-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 198..256
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT ZN_FING 285..314
FT /note="C3H1-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
SQ SEQUENCE 350 AA; 39190 MW; EA72EB9F5B66FE8A CRC64;
MSKRILCKFF AHGACLKGEH CEFSHDWKDP TNNICTYYQK GICSYGSRCR YEHVKASRPH
PSASSSSAVP RPSPASASNT LACAFLPGVA ERDLSPVPSS SLKPTWNLDS LHQDSVDEVK
TSNPGTVKPE ELPICSFAAA GDCPRGNECP HIHGTICPTC GKCCLHPFRP DEREEHKKVC
EKKHKQLEAL KLSQEIECCV CLERVLSKAT PAERKFGLLT ECDHAFCIAC IRNWRSSSPS
TGMDVNSTLR ACPICRKLSY FVVPSVIWFS APEEKKEIMD NYREKLRSID CKHFSFGDGN
CPFGTSCFYK HAYHDGRLEE VVLRHLDAED GQTVIAKDIR LSDFLENMHI
