ID   TSN18_MOUSE             Reviewed;         248 AA.
AC   Q80WR1;
DT   21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Tetraspanin-18;
DE            Short=Tspan-18;
GN   Name=Tspan18;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR   EMBL; BC052169; AAH52169.1; -; mRNA.
DR   CCDS; CCDS38182.1; -.
DR   RefSeq; NP_899003.1; NM_183180.2.
DR   RefSeq; XP_006499537.1; XM_006499474.3.
DR   RefSeq; XP_006499538.1; XM_006499475.3.
DR   RefSeq; XP_006499539.1; XM_006499476.3.
DR   RefSeq; XP_006499540.1; XM_006499477.3.
DR   RefSeq; XP_011237827.1; XM_011239525.2.
DR   AlphaFoldDB; Q80WR1; -.
DR   SMR; Q80WR1; -.
DR   STRING; 10090.ENSMUSP00000106896; -.
DR   GlyGen; Q80WR1; 1 site.
DR   MaxQB; Q80WR1; -.
DR   PaxDb; Q80WR1; -.
DR   PRIDE; Q80WR1; -.
DR   ProteomicsDB; 297984; -.
DR   Antibodypedia; 68460; 62 antibodies from 10 providers.
DR   DNASU; 241556; -.
DR   Ensembl; ENSMUST00000028646; ENSMUSP00000028646; ENSMUSG00000027217.
DR   Ensembl; ENSMUST00000111265; ENSMUSP00000106896; ENSMUSG00000027217.
DR   GeneID; 241556; -.
DR   KEGG; mmu:241556; -.
DR   UCSC; uc012bzr.1; mouse.
DR   CTD; 90139; -.
DR   MGI; MGI:1917186; Tspan18.
DR   VEuPathDB; HostDB:ENSMUSG00000027217; -.
DR   eggNOG; KOG3882; Eukaryota.
DR   GeneTree; ENSGT00940000157667; -.
DR   HOGENOM; CLU_055524_4_1_1; -.
DR   InParanoid; Q80WR1; -.
DR   OMA; ACCQREP; -.
DR   OrthoDB; 1232467at2759; -.
DR   PhylomeDB; Q80WR1; -.
DR   TreeFam; TF352892; -.
DR   BioGRID-ORCS; 241556; 2 hits in 72 CRISPR screens.
DR   PRO; PR:Q80WR1; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; Q80WR1; protein.
DR   Bgee; ENSMUSG00000027217; Expressed in floor plate of midbrain and 203 other tissues.
DR   Genevisible; Q80WR1; MM.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   Gene3D; 1.10.1450.10; -; 1.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR000301; Tetraspanin_animals.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2_sf.
DR   PANTHER; PTHR19282; PTHR19282; 1.
DR   Pfam; PF00335; Tetraspanin; 1.
DR   PIRSF; PIRSF002419; Tetraspanin; 1.
DR   SUPFAM; SSF48652; SSF48652; 1.
DR   PROSITE; PS00421; TM4_1; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..248
FT                   /note="Tetraspanin-18"
FT                   /id="PRO_0000219269"
FT   TOPO_DOM        1..13
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        35..49
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        71..83
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        105..223
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        245..248
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        129
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   248 AA;  27801 MW;  5F5F416856DAF72C CRC64;
     MEGDCLSCMK YLMFVFNFFV FLGGACLLGV GIWVLVDPTG FREIVATNPL LTTGAYIVLA
     MGGLLFLLGF LGCCGAVREN RCLLLFFFLF ILIIFLVELS AAILAFIFRE HLTREFFTKE
     LTKHYQGDND TDVFSATWNS VMITFGCCGV NGPEDFKLAS VFRLLTLDTE EVPKACCRRE
     PQTRDGVVLS REECQLGRNP FINKQGCYTV ILNTFETYVY LAGAFAIGVL AIELFLMVFA
     MCLFRGIQ